15 December 2021 Eosinophil Gastrointestinal Diseases (EGID)
Eosinophil Gastrointestinal Diseases (EGID)
9:30-11:00 AM ET
Webinar Sponsored by:
Rapid activation of mucosal mast cells drives epithelial barrier dysfunction in Eosinophilic Esophagitis
Joshua B. Wechsler, MD
Attending Physician, Division of Gastroenterology, Hepatology, & Nutrition
Assistant Professor in Pediatrics, Northwestern University Feinberg School of Medicine
Dr. Wechsler is a physician-scientist at Ann & Robert H. Lurie Children's Hospital of Chicago, part of Northwestern University Feinberg School of Medicine. He is a board certified pediatric gastroenterologist and has a masters of science in clinical investigation. He is currently an Assistant Professor in Pediatrics and Medicine, and is the CURED Foundation Research Scholar, and Director of the Eosinophilic Gastrointestinal Disease Center at Lurie Children's Hospital. Dr. Wechsler is passionate about Eosinophilic Gastrointestinal Diseases and seeks to improve the quality of life of his patients through research. Dr. Wechsler has made key contributions regarding dietary treatments, endoscopic abnormalities, biomarkers, and mast cells in children with EoE, and is an active site investigator for the Consortium of Eosinophilic Gastrointestinal Diseases Researchers (CEGIR). Dr. Wechsler's laboratory is focused on the role of mast cell activation and mediators in Eosinophilic Gastrointestinal Diseases, and seeks to identify novel targets to improve patient outcomes.
Intestinal tissue eosinophils in health and inflammation: Heterogeneity, plasticity and regulation
Lisa Spencer, PhD
Associate Professor of Pediatrics at the University of Colorado School of Medicine, and Scientific Director of research in the Gastrointestinal Eosinophilic Diseases Program
Lisa Spencer, PhD, is an Associate Professor of Pediatrics at the University of Colorado School of Medicine, and Scientific Director of research in the Gastrointestinal Eosinophilic Diseases Program, within the Digestive Health Institute at the Children’s Hospital Colorado. Her primary research focus is to understand how mucosal tissue eosinophils both restore homeostasis and drive inflammation and to leverage this understanding in development of improved eosinophil-modulating therapeutic approaches. The Spencer Lab integrates studies with primary human cells and biopsy tissues with in vivo mouse models to maintain translational relevancy while taking full advantage of manipulatable mouse models. Dr. Spencer’s published work has contributed seminal findings to the field, including a deeper understanding of secretory mechanisms of human eosinophils, pathways regulating eosinophil survival and function, and impacts of mucosal organ crosstalk on modulating eosinophil tissue sub-phenotypes in allergic diseases.