Praveen M. Akuthota, MD
Member Profile
Affiliation
University of California, San Diego
Specialty
Eosinophil Antigen Presentation, Eosinophil Chemotaxis, Eosinophilic Lung Disease, Asthma
Publications
- Akuthota P, Ueki S, Estanislau J, Weller PF. Human Eosinophils Express Functional CCR7. Am J Respir Cell Mol Biol. 2013; 48(6):758-764.
- Akuthota P, Spencer LA, Melo RC, Weller PF. MHC Class II and CD9 in Human Eosinophils Localize to Detergent-Resistant Membrane Microdomains. Am J Respir Cell Mol Biol. 2012; 46(2):188-195.
- Akuthota P, Spencer LA, Melo RC, Weller PF. MHC Class II and CD9 in Human Eosinophils Localize to Detergent-Resistant Membrane Microdomains. Am J Respir Cell Mol Biol. 2012; 46(2):188-195.
- Akuthota P, Weller PF. Spectrum of Eosinophilic End-Organ Manifestations. Immunol Allergy Clin North Am. 2015, 35(3):403-411.
Research
My research efforts center around both basic scientific investigations of human eosinophil biology and clinical investigation of eosinophilic lung disease. Recent published work demonstrates that human eosinophils express functional CCR7, a key chemokine receptor involved in leukocyte trafficking. This work provides the basis for a project supported by a K08 Career Development Award that aims to addresses the overall hypothesis that CCR7 receptor-ligand interactions on eosinophils have an integral role in allergic airways disease that promotes resolution of Th2 inflammation and tissue eosinophilia. Another published line of investigation explores the role of lipid raft and tetraspanin networks in antigen presentation by human eosinophils. Along with many other IES members,I have been active as a co-investigator in a study of the efficacy of anti-IL-5 monoclonal antibody in the treatment of Churg-Straus syndrome.
