Below is listed a current job opening in the IES field.
Title:Postdoc on Eosinophil Ontogeny and Heterogeneity
Employer: Laboratory of Cellular and Molecular Immunology (LCMI) of Liege University
Location: Liege, Belgium
Areas of interest: Immune cell development, hematopoiesis, mouse and human eosinophil function, differentiation and heterogeneity, allergic diseases, single-cell RNA sequencing
A one-year full-time post-doctoral position with a possibility of extension for 3 additional years is available in the Laboratory of Cellular and Molecular Immunology (LCMI, www.giga.ulg.ac.be/lcmi) of Liege University in Belgium. The established group that the successful applicant would join recently documented the existence of at least 2 subsets of eosinophils in mice. The proposed project aims at characterizing eosinophil heterogeneity in mouse and human, as well as at resolving the respective ontogeny of said subsets using mouse models and existing and newly generated transgenic mouse strains. You would work with an international team of veterinarians and biologists within the LCMI. The LCMI is part of the Interdisciplinary Group of Applied Genoproteomics (GIGA-R) Institute, which gathers more than 600 researchers in different areas of cellular and molecular biology and medicine. GIGA-R is located on the site of the University Hospital, which facilitates the translational aspects of the project, and disposes of top-notch mutualized technological platforms (10X Genomics, FACS Aria II, BD Fortessa, …). The project is funded by the inter-University Excellence of Science (EOS) initiative of the Belgian Federal State and will be run in close collaboration with other leading teams in Belgium.
We are looking for a highly motivated researcher with a PhD degree in cellular or molecular biology/medicine or assimilated, preferably in the field of hematology/immunology and ideally with experience in the field of eosinophil research. You must have a good publication record demonstrating experience with common cellular and molecular biology techniques. You should ideally have expertise in one or several of the following areas: proficiency with animal models and certification to work with laboratory animals (FELASA C or equivalent), extensive knowledge of flow cytometry, generation and use of retro/lentiviral vectors. Fluency in oral and written English, an independent mind yet with a good team spirit and excellent communication and organizational skills are essential requirements.
What we offer:
- A high profile research project, fully financed by highly competitive grants
- A modern, international and well-equipped research environment with state-of-the-art technological platforms (e.g. for animal care, genomics, viral vectors, flow cytometry and microscopy)
- An attractive salary in an affordable, lively and welcoming environment
Please send your motivation letter, including a description of your past research experience and of how you feel it may contribute to the project, along with the following documents in English:
- Curriculum vitae, including date of your PhD defense, previous academic position(s), current position, complete list of publications, list of laboratory skills, and other relevant information (grants, awards, supervision of students, etc…),
- A copy of your PhD diploma,
- Contact details of at least 2 references, preferably current or former supervisors.
Please send your application to Christophe Desmet (firstname.lastname@example.org) before March 1st 2018. We will notify candidates as quickly as possible about the suitability of their application and further interview shortlisted candidates shortly after the application deadline.
Selected recent publications
1. Mesnil C*, Raulier S*, Paulissen G, Xiao X, Birrell MA, Pirottin D, Janss T, Starkl P, Ramery E, Henket M, Schleich FN, Radermecker M, Thielemans K, Gillet L, Thiry M, Belvisi MG, Louis R, Desmet C, Marichal T*, Bureau F*. Lung-resident eosinophils represent a distinct regulatory eosinophil subset. J Clin Invest. 2016, 126(9):3279-95. doi: 10.1172/JCI85664.
2. Sabatel C*, Radermecker C*, Fievez L, Paulissen G, Chakarov S, Fernandes C, Olivier S, Toussaint M, Pirottin D, Xiao X, Quatresooz P, Sirard JC, Cataldo D, Gillet L, Bouabe H, Desmet CJ, Ginhoux F, Marichal T*, Bureau F*. Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages. Immunity. 2017, 46(3):457-473. doi: 10.1016/j.immuni.2017.02.016.
3. Toussaint M, Jackson DJ, Swieboda D, Guedán A, Tsourouktsoglou TD, Ching YM, Radermecker C, Makrinioti H, Aniscenko J, Edwards MR, Solari R, Farnir F, Papayannopoulos V, Bureau F*, Marichal T*, Johnston SL*. Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation. Nat Med. 2017, 23(6):681-691. doi: 10.1038/nm.4332.
4. Marichal T, Ohata K, Bedoret D, Mesnil C, Sabatel C, Kobiyama K, Lekeux P, Coban C, Akira S, Ishii KJ*, Bureau F*, Desmet CJ*. DNA released from dying host cells mediates aluminum adjuvant activity. Nat Med. 2011, 17(8):996-1002. doi: 10.1038/nm.2403.