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2019 Biennial Symposium

Scientific Program

 

The initial schedule for the 2019 IES Symposium is listed below.

IES Scientific Program                   

Tuesday 9 July

Welcome Reception (Portland Marriott Downtown Waterfront)

18:00 - 18:30 Welcome -
Bruce Bochner, USA & Allison Fryer, USA

18:30 - 19:00 History of Eosinophil Discovery or Why Did Eosinophils Capture My Attention - Jerry Gleich, USA

19:00 - 21:00 Welcome Reception

                               

Wednesday 10 July

07:00 - 08:00 Breakfast with a Mentor Session: How to Navigate a Scientific Conference - Jackie Wirz, USA

Session 1: Eosinophils Across Species, What Does That Tell Us About Their Physiological Role, Evolution and Choice of Animal Models

08:15 - 08:45 On the Origin of Eosinophils by Means of Natural Selection: Preservation of a Favored Leukocyte in the Struggle for Life - Steve Ackerman, USA

08:45 - 09:15 Eosinophils and Disease Models from Mouse to Man: We are Stronger Together - Helene Rosenberg, USA

09:15 - 09:45 Eosinophil Identity in the Tissue Contexts of Development, Homeostasis, and Disease - Sergejs Berdnikovs, USA

Abstract Presentations

09:45 - 10:00 Real-Time in Vivo Imaging of Tissue Resident Eosinophils Under Homeostatic and Inflammatory Conditions - Kamala D. Patel, Canada

                               

10:00 - 10:30 Morning Break

        

Session 2: Eosinophil Life Cycle, Hematopoiesis and Recruitment, Activation and Death

10:30 - 11:00 Hemopoietic Mechanisms in Eosinophilic Inflammation - Roma Sehmi, Canada

11:00 - 11:30 Eosinophils in Liver Death - Todd Davidson, USA

11:30 - 12:00 Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation - Shigeharu Ueki, Japan

12:00 - 12:30 Eosinophil Shape Change and Granule Secretion - Paige Lacy, Canada

12:30 - 13:00 IES Business Meeting

                               

13:00 - 14:30 Lunch (on your own)

                       

14:30 - 15:30 Gleich Award Winner Lecture -
Eosinophil Depletion Suppresses Radiation-Induced Small Intestinal Fibrosis
- Naoki Takemura, Japan

15:30 - 16:00 Eosinophil Extracellular DNA Traps in Skin Diseases - Dagmar Simon, Switzerland

Abstract Presentations

16:00 - 16:15 First Ultrastructural Demonstration of Galectin-10 in Resting and Activated Human Eosinophils - Rossana Melo, Brazil

16:15 - 16:30 SIGLEC-8 Signals Through an Unanticipated Set of Molecules to Induce Integrin Upregulation and Activation, ROS Production, and Cell Death in Eosinophils - Jeremy O'Sullivan, USA

                               

17:00 - 19:00 Poster Session 1

                               

Poster 1 - Eosinophil Infiltration Does Not Exacerbate Muscle Pathology in the MDX Mouse Model of Duchenne Muscular Dystrophy - Albert Sek

Poster 3 - In Vitro and In Vivo Inhibition of Eosinophil Activation by Lysophosphatidylcholine and Synthetic Alkyl-Lysophosphatidylcholine - Eva Knuplez

Poster 5 - Characterizing SIGLECF+GR1- and SIGLECF+GR1+ Mouse Bone Marrow-Derived Eosinophils (bmEos) Cultured Ex Vivo - Eric Mai

Poster 9 - Nasal Polyps as a Presenting Sign of Systemic Eosinophilic Diseases - Yossi Rosman

Poster 11 - Dexpramipexole Responsiveness is increased in Eosinophilic Patients - Calman Prussin

Poster 13 - Single Site, Five-Year Experience with Human Eosinophil Isolation by Density Gradient Centrifugation and Immunomagnetic Negative Separation - Yun Cao

Poster 15 - Genetic Variation in Surfactant Protein-A2 and the Effect on Eosinophil Resolution in Allergic Airways - Alane Blythe C. Dy

Poster 17 - Eosinophil Cytolysis on IGG Requires Microtubule Array Formation, and P-38 Phosphorylation Downstream of Reactive Oxygen Species Production - Stephane Esnault

Poster 19 - IL-9 and IL-13 Storage and Release from Eosinophils - Sarah Almas

Poster 21 - The Role of Eosinophils in Obesity-Related Asthma - Gina Calco

Poster 23 - Kinetic Studies of Galectin-10 Release From Eosinophils to Proliferating T Cells - Christine Lingblom

Poster 25 - Eosinophil Responses to IL-4, IL-33 and Bacteria are Differentially Regulated by Apoptotic Cells - Avishay Dolitzky

Poster 27 - Harnessing Hymenolepis Diminuta Extract to Active Anti-Tumorigenic Activities of Eosinophils in Colorectal Cancer - Inbal Hazot

Poster 29 - Granulocyte Kinetics in the Blood and Sputum of Patients with Eosinophilic and Neutrophilic Inflammation - Leo Koenderman

Poster 31 - IGG4-Related Disease and Hypereosinophilic Syndrome: Overlapping Phenotypes? - Matthieu Groh

Poster 33 - Allergic Bronchopulmonary Aspergillosis as a Complication of COPD: A New Entity? - Matthieu Groh

Poster 35 - Intrinsic Sex-Specific Differences in Fibrotic Gene Expression and Pathology Contribute To Male Disease Predisposition in Pediatric Eosinophilic Esophagitis - Loan Duong

Poster 37 - Urine Levels Of Eosinophil Granule Proteins; A Better Biomarker of Eosinophilic Disease Activity? - Michelle Makiya

Poster 39 - Fluid Shear Stress Induces Rapid Actin Rearrangement in Eosinophils - Kiho Son

Poster 41 - Kruppel-Like Factor 3 (KLF3) Regulates Adipose Tissue Beiging via Eosinophils - Emily Vohralik

Poster 43 - Association of Blood Eosinophil Phenotypes and Patient Self-Assessment Data with Response to Treatment in Eosinophilic Esophagitis - Sofie Albinsson

Poster 45 - Eosinophilic Gastrointestinal Disease Treatment Approaches are Associated with Frequency of Feelings of Isolation - Elizabeth Jensen

Poster 47 - Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared To Common Beta-Chain Cytokines IL-5 and GM-CSF - Praveen Akuthota

Poster 49 - Eosinophils Suppress TH1 Responses and Restrict Bacterially Induced Gastrointestinal Inflammation - Isabelle Arnold

Poster 51 - Clinical and Endoscopic Features of the Fibrostenotic Phenotype in Eosinophilic Esophogitis - Paul Fichtinger

Poster 53 - Molecular, Endoscopic, Histological and Circulating Biomarker-Based Diagnosis of Eosinophilic Gastritis: Cross Sectional Multi-Site Study - Tetsuo Shoda

Poster 55 - Eosinophils are Present in Human and Mouse ESCC Tumors and May Be Protective in Tumorigenesis - Yash Choksi

Poster 57 - Eosinophils Alter Steady-State Small Intestinal IL-1α and IL-1ß Levels but are not Required for the Maintenance of Secretory IGA nor for Control of an Enteric Bacterial Pathogen - Rachael Brown

Poster 59 - Transgenic Expression of a Novel Secreted Active Form of IL-33 Promotes Eosinophilia in a Mouse Model of Eosinophilic Esophagitis - Benjamin Wright

Poster 61 - Hypereosinophilia Associated with Clonal CD3-CD4+ T Cells:  Characterization and Outcome of a New Cohort of Patients - Sylvain Verbanck

Poster 63 - CD200R1 is Upregulated in the Esophageal Epithelium in Eosinophilic Esophagitis - Netali Ben Baruch-Morgenstern

Poster 65 - Eosinophil Subtype Specific Metabolic Activities - Elizabeth Jacobsen

Poster 67 - Eosinophils Modulate ILC2 Activities - Elizabeth Jacobsen

Poster 69 - Inhibition of Eosinophil Transendothelial Migration by 5HTP Stimulation of HTR1A and HTR1B in Endothelial Cells - Joan Cook-Mills

Poster 71    PIN1 Regulates IL-5 Induced Eosinophil Polarization and Migration - Zhong-Jian Shen

Poster 73    Adipose Tissue Eosinophils in Cancer-Associated Cachexia - Patrick Lenehan

Poster 75    Pharmacodynamic And Clinical Efficacy Data from Patient Sputum Subgroups in DREAM Treated with Mepolizumab Across A 10-fold Dose Range - Charlene Prazma

Poster 77    Palmitoylation of Galectin-10 in Human Eosinophils - Haibin Wang

 

Thursday 11 July

07:00 - 08:00 Breakfast with a Mentor Session: How NIH Supports Clinical Trials - Lisa Wheatley, USA

07:00 - 08:00 Breakfast with a Mentor Session: Program Officers, Study Sections, RFA and PAs: Learn the language, protocols and best practices to interact with the NIH - Michael Minnicozzi, USA

Session 3: Eosinophils and Host Defense

08:00 - 08:30 When Eosinophils Meet Viruses - Amali Samarasinghe, USA

08:30 - 09:00 Eosinophils Suppress Th1 Responses and Restrict Bacterially Induced Gastrointestinal Inflammation - Isabelle Arnold, Switzerland

09:00 - 09:30 Eosinophil Phenotypes in Immune Pathways - Elizabeth Jacobsen, USA

Abstract Presentations

09:30 - 09:45 Single Cell RNA Sequencing of Inflammatory Tissue T Cells in Eosinophilic Esophagitis - Ting Wen, USA

09:45 - 10:00 Identification of Eosinophil-Specific Gene-Enhancer Regions - Jennifer Felton, USA

                               

10:00 - 10:30 Morning Break

                               

Session 4: Eosinophils and Nerves

10:30 - 11:00 Maternal Inflammation and Offspring Eosinophils Regulate Airway Nerve Development  - Katie Lebold, USA

11:00 - 11:30 Eosinophils Promote Sensory Nerve Growth in Human Asthma - Matthew Drake, USA

11:30 - 12:00 Eosinophils and Itch - David Jacoby, USA

Abstract Presentations

12:00 - 12:15 Asthma is Associated With Brain Neurodegeneration: A Possible Effect of Eosinophilic Inflammation? - William Busse, USA

12:15 - 12:30 Characterization of a Mouse Model of Heart Disease in Hypereosinophilia - Nives Zimmermann, USA

                               

12:30 - 15:00 Lunch (on your own)

 

Session 5: Eosinophils and Metabolic Disease

15:00 - 15:30 Extreme IL-33-Dependent Eosinophil Accumulation in Adipose Tissue - Alyssa Hasty, USA

Abstract Presentations

15:30 - 15:45 The Role of Adipose Tissue-Resident Eosinophils in Adipocyte Metabolism and Whole-Body Energy Homeostasis - Elena Anna De Filippis, USA

15:45 - 16:00 Eosinophils in Beige Adipose Tissue Activation - Kate Quinlan, Australia

 

16:00 - 17:00 Ehrlich Award Winner Lecture - Regulation and Control of Eosinophilia - Marc Rothenberg, USA

                               

17:00 - 19:00 Poster Session 2

                               

Poster 2 - Eosinophils from Normal Donors How Do They Vary? How Do They Define Us? - Caroline Percopo

Poster 4 - Determining the Role of Eotaxin-1 in Eosinophil Development In Order To Promote Heterogeneity via an Ex Vivo Cuture System - Ajinkya Limkar

Poster 6 - Eosinophilia and Hookworm Infection: A Living Drug for Autoimmune Diseases - David Pritchard

Poster 8 - Sustained Long-Term Efficacy and Safety of RPC4046, an Anti-Interleukin-13 Monoclonal Antibody, In Patients with Eosinophilic Esophagitis: Results from the Open-Label Extension of the Heroes Study - Cristian Rodriguez

Poster 10 - Markers of Esophageal Epithelial-Mesenchymal Transition (EMT) are Significantly Reduced in Active Eosinophilic Esophagitis Following 16 Weeks of Treatment with RPC4046, an Anti-Interleukin-13 Monoclonal Antibody - Cristian Rodriguez

Poster 12 - Differentiation and Activation of Eosinophils in the Human Bone Marrow at Steady State and During Experimental Acute Systemic Inflammation - Marwan Hassani

Poster 14 - Activated Eosinophils Promote an Anti-Tumorigenic Environment in Tumor Models of Colorectal Cancer - Melanie Kienzl

Poster 16 - Vitamin Deficiencies May Vary in Relation to Symptoms and Treatment Approaches for Eosinophilic Esophagitis - Elizabeth Jensen

Poster 18 - Epidermal Expression of Eotaxins-1, 2, and 3 in Bullous Pemphigoid is Comparable to Other Eosinophil Rich Dermatoses: A Retrospective Immunohistochemical Analysis - Kyle Amber

Poster 20 - Detection of Eosinophil Cytolytic Degranulation in Paraffin-Embedded Tissue - Mineyo Fukuchi

Poster 22 - Human Eosinophils Express of Free Fatty Acid Receptor 2 And 3: Possible Implication of These Receptors in Interleukin-4 Production by Short Chain Fatty Acids - Myeong Seong Sim

Poster 24 - Intraesophageal Adminisration of Oxazolon to Skin-Sensitized? Mice Results In Experimental Eosinophilic Esophagitis - Shmuel Avlas

Poster 28 - Regulation of Eosinophil Recruitment in Allergic Airway Inflammation by Tropomyosin Receptor Kinase A - Mythili Dileepan

Poster 30 - Aspergillus Fumigatus-Induced Human Eosinophil Extracellular DNA Traps: Role of IP3K, p38 MAPK and Src Family - Marina Barroso

Poster 32 - Improved Diagnosis of Asthma: Metabolomic Profiling of Urine - Darryl Adamko

Poster 34 - AKST4290, a CCR3 Inhibitor, Is Efficacious In Models of Age-Related Eosinophilic Disorders - Arnaud Teichert

Poster 36 - The TNF Superfamily Member 14 (TNFSF14/Light) Induces Pro-Inflammatory Responses in Fibroblasts in Eosinophilic Esophagitis - Mario Manresa

Poster 38 - Lysophosphatidylserine Induces Eosinophil Extracellular Trap Cell Death - Hye Jeong Kim

Poster 40 - The Thiazolidinediones as Potential Therapeutic Agents for Eosinophilic Esophagitis Pathologic Remodeling: A Preclinical Evaluation - Quan Nhu

Poster 42 - Serum Eotaxin-1/CCL11 Levels Are Elevated in Severe Forms of Systemic Sclerosis - Guillaume Lefèvre

Poster 44 - A Functional Role for Eosinophils in Host Resistance against Mycobacterium Tuberculosis - Katrin Mayer-Barber

Poster 46 - Identification of Reactive Oxygen Species Production Site in Siglec-8 Induced Eosinophil Death - Toshihiro Tomii

Poster 48 - Efficacy and Tolerance of Interferon-Alpha in Hypereosinophilic Syndromes. A Retrospective, Multicenter Study on 29 Patients - Jean Emmanuel Kahn

Poster 50 - Eosinophil Subsets in Pediatric Exacerbation-Prone Asthma - Li Merlin

Poster 52 - Eosinophil Associated Type-2 Gene Expression in Childhood Asthma - Matthew Altman

Poster 54 - Improvement in Quality Of Life (QOL) In Pediatric Patients with Eosinophilc Esophagitis and Food Allergy after Initial Clinic Evaluation - Vibha Szafron

Poster 56 - IL-33 Expression and Potential Activation of Eosinophils Is Associated with ORMDL3 - Elizabeth Mckernan

Poster 58 - Quantifying Mucosal Eosinophilic Inflammation in EOE Using the 1-Hour Esophageal String Test - Milica Grozdanovic

Poster 60 - Elevated Serum Tarc in Patients with Idiopathic Hypereosinophilic Syndrome: A Marker of Lymphocyte- Driven Disease? - Julien Catherine

Poster 62 - IL-13 Treated Esophageal Epithelial Cells Induce Eosinophil Survival and Activation - Julia Dunn

Poster 64 - Effects of Sustained Eosinophil Depletion in Humans - Fei Li Kuang

Poster 66 - Expression and Function of Type 1 and Type 2 Eosinophils - Elizabeth Jacobsen

Poster 68 - Eosinophils Suppress Lung Allograft Rejection - Elizabeth Jacobsen

Poster 70 - Early Life Represents a Vulnerable Time Window for IL-33-Induced Lung Pathology - Hirohito Kita

Poster 72     Multiple Roles of PIN1 in the Regulation of TLR7 Signaling in Eosinophils - Zhong-Jian Shen

Poster 74     Steroid Dose Reducing Effect of Benralizumab, a Monoclonal Antibody to IL-5Ra, In Eosinophilic Granulomatosis with Polyangiitis - Vamsi P. Guntur

Poster 76     Oral Corticosteroid Dose Modulation in Severe Asthma: Impact on Peripheral Blood Eosinophil Count - Charlene Prazma

Poster 78     Eosinophils Dampen Hepatic Ischemia Reperfusion Injury through Interleukine-33 Signaling - Jong-Min Jeong

 

Friday 12 July

Session 6: Eosinophils in Chronic Inflammatory Disease - Asthma

08:00 - 08:30 ASTHMA - Autoimmune Responses, Eosinophils and Complex Airway Disease - Manali Mukherjee, Canada

08:30 - 09:00 ASTHMA - Anti IL5 Therapies for Severe Asthma: Targeting The Ligand vs The Receptor - Parameswaran Nair, Canada

09:00 - 09:30 LUNG - Targeting Eosinophils in Eosinophil Granulomatosis with Polyangitis - Michael E. Wechsler, USA

Abstract Presentations

09:30 - 09:45 Lung Eosinophils Increase Vagus Nerve Mediated Airway Reflex Bronchoconstriction in Mice - Zhenying Nie, USA

09:45 - 10:00 Idiopathic Eosinophilic Vasculitis, Another Side of Hypereosinophilic Syndrome? A Comprehensive Analysis of 115 Cases in Asthma-Free and ANCA-Negative Patients - Guillaume Lefèvre, France

                               

10:00 - 10:30 Morning Break

                               

Session 7: Eosinophils in Chronic Inflammatory Disease- GI

10:30 - 11:00 ESOPHAGUS - Eosinophilic Esophagitis-like Disease:  Description of a New Disease Entity – Hans-Uwe Simon, Switzerland

11:00 - 11:30 GI OR SUBSETS - Phenotypically Distinct Subsets of Eosinophils Resident in Intestine - Lisa Spencer, USA

11:30 - 12:00 GI - Markers of Chronic Inflammatory Bowel Disease - Marie Carlson, Sweden

12:00 - 12:30 GI and SKIN - A Pathophysiological Potpourri of Conundrums and Challenges in Eosinophil-Related Epithelial Inflammation - Kristin Leiferman, USA

Abstract Presentations

12:30 - 12:45 Functional Role of Kallikrein 5 and Proteinase Activated Receptor (PAR)2 in Eosinophilic Esophagitis - Nurit Azouz, USA

12:45 - 13:00 Efficacy of RPC4046, An Anti-Interleukin-13 Monoclonal Antibody, In Patients with Active Eosinophilic Eosphagitis: Analysis of the Steroid-Refractory Subgroup From the Heroes Study - Cristian Rodriguez, USA

                               

13:00 - 15:00 Lunch (on your own)

13:00 - 15:00 CEGIR Lecture Session - "Findings from the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)"

  • Introduction and Structure of CEGIR - Marc Rothenberg, United States
  • Early Findings from the CEGIR EGID Observational Cohort - Ikuo Hirano, United States
  • Partnering with Patients - Seema Aceves, Untied States and Representatives from PAGS
  • Logistical Operations-Publications and Data Sharing - Sandeep Gupta, United States
  • Training the Next Generation of EGID Leaders - Quan Nhu, United States
  • NIAID Interests and Roles in Disease Consortia - Lisa Wheatley, United States and Mike Minnicozzi, United States
  • Questions and Answers and Discussion

(lunch available for purchase during registration)

    

Session 8: Eosinophils in Cancer                         

15:00 - 15:30 Activated Eosinophils Exert Distinct Anti-Tumorigenic Activities in Colorectal Cancer - Ariel Munitz, Israel

15:30 - 16:00 Charcot-Leyden Crystals as a Drugable Target in Type 2 Immunity - Bart Lambrecht, United States

Abstract Presentations

16:00 - 16:15 Eosinophils Promote GM-CSF-Dependent Anti-Tumor Immunity Through Activation of Type I T-Cell Responses - Alessandra Gurtner, Switzerland

16:15 - 16:30 Activated Eosinophil Subsets are an Integral Part of the Tumor Microenvironment in Lung Metastasis, Displaying Anti-Tumorigenic Activities - Sharon Grisaru, Israel

                               

 

 

Saturday 13 July

Session 9: The Now and Future of Eosinophils as a Drug Target

08:00 - 08:30 “Siglec”ting the Allergic Response for Therapeutic Targeting - Bruce Bochner, USA

08:30 - 09:00 Developing Dexpramipexole for the Treatment of Eosinophilic Disorders - Calman Prussin, USA

09:00 - 09:30 Subtypes of Responders to Treatment in Hypereosinophilic Syndrome - Paneez Khoury, USA

09:30 - 10:00 Eosinophil Depletion in Humans: Is It Safe? - Amy Klion, USA

10:00 - 10:30 EOS, Exacerbations and Adherence…The Good, Bad and Ugly of Severe Asthma - Richard Costello, Ireland

Abstract Presentation

10:30 - 10:45 Alpha IIb Integrin (CD41) on Blood Eosinophils is a Potential Biomarker for Disease Activity in Eosinophilic Esophagitis (EoE) - Mats Johansson, USA

                               

10:45 - 11:15 Morning Break

                               

11:15 - 12:15 Roundtable Discussion 1 - New Emerging or Controversial Topics - Is There More Than One Type of Eosinophil?

12:15 - 13:15  Roundtable Discussion 2 - New Emerging or Controversial Topics - Eosinophils-What are They Good For?

*Schedule Subject to Change