Daily Program
8:00 - 5:00 pm |
Hypereosinophilic Syndrome Pre-Meeting Workshop:
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8:00 - 10:00 am |
Session I: Introduction |
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8:00 - 8:15 am |
Introductory Remarks |
Amy Klion, USA |
8:15 - 9:45 am |
Multicenter Retrospective Analysis as a Tool for Rare Disease Research: Successes and Limitations |
Princess Ogbogu, USA |
9:45 - 10:00 am |
Retrospective Multicenter Study of Biologics in HES – Summary of Results and Remaining Questions |
Bruce Bochner, USA |
10:00 - 10:30 am |
Coffee Break |
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10:30 - 12:00 pm |
Session II: Biologics in Rare Eosinophil-Associated Diseases |
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10:30 - 11:00 am |
Predictors of Response to Biologics in EAD |
Florence Roufosse, Belgium |
11:00 - 11:30 am |
Safety Considerations |
Fei Li Kuang, USA |
11:30 - 12:00 pm |
Biomarkers and Clinical Outcome Measures of Disease Activity in EAD |
Praveen Akuthota, USA |
12:00 - 12:45 pm |
Lunch |
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12:45 - 3:00 pm |
Session III: Approach to the Study of Biologics in EAD - Focus Groups |
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3:00 - 3:30 pm |
Coffee Break |
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3:30 - 4:30 pm |
Session IV: Conclusions and Future Directions |
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3:30 - 4:30 pm |
Focus Group Presentations |
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4:30 - 5:00 pm |
Summary and Action Items |
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Workshop SupporterGrant SupportFunding for this workshop was made possible (in part) by support from NCATS. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the NIH; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S Government. |
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6:00 – 7:30 pm |
Welcome to the 12th Biennial Symposium of the International Eosinophil SocietyChair: Mark Larché, Canada (Scientific Program Chair) |
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6:00 – 6:10 pm |
Welcome from McMaster University |
Paul O’Byrne, Canada |
6:10 – 6:40 pm |
Welcome Lecture: The Clinical Biology of Eosinophils: A Saga |
Judah Denburg, Canada |
6:45 – 7:15 pm |
What have we Learned about Eosinophils and Eosinophilic Disorders from Eosinophil-Targeted Therapeutics |
Gail Gauvreau, Canada |
7:30 – 9:30 pm |
Welcome ReceptionArt Gallery of Hamilton |
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Return to Symposium Homepage
7:00 am - 8:00 am |
Breakfast Breakouts |
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Breakfast Breakout 1: Roles in Academic Leadership |
Allison Fryer, USA |
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Breakfast Breakout 2: Career Progression in the World of Eosinophils |
Fei Li Kuang, USA |
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Breakfast Breakout 3: Alternate Non-Academic Career Paths |
Claudia Hui, Canada |
8:00 – 10:00 am |
Session 1: Regulation of Eosinophil DevelopmentChairs: Sergejs Berdnikovs, USA & Zhenying (Jane) Nie, USA |
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8:00 – 8:25 am |
State-of-the-Art: 'Haeckel'ing Evolution of Eosinophils and Function: "Ontogeny Recapitulates Phylogeny"…or Does It? |
Steven Ackerman, USA |
8:25 – 8:45 am |
Cutting-Edge: Metabolic Reprogramming and Stromal Support in Generation of Long-Lived Eosinophils |
Sergejs Berdnikovs, USA |
8:45 – 9:05 am |
Cutting-Edge: Myeloid Progenitor Differentiation Pathways Identified through scRNAseq |
Claus Nerlov, UK |
9:05 – 9:25 am |
Cutting-Edge: Expanding Landscape of Myeloid Neoplasms with Gene Rearrangement and Eosinophilia |
Nives Zimmermann, USA |
9:25 – 9:40 am |
Oral Abstract: Single-Cell RNAseq Reveals Transcriptional Heterogeneity Of Eosinophils And Basophils In Human Blood |
Irene Whitney, USA |
9:40 – 9:55 am |
Oral Abstract: IRF1 is a Major Regulatory Transcription Factor for Immune Responses in Eosinophils |
Elizabeth A. Jacobsen, USA |
10:00 – 10:30 am |
Break |
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10:30 - 12:30 pm |
Session 2: Cell Death (and Stress, Autophagy) in Eosinophil BiologyChairs: Jennifer M. Felton, USA & Rossana Melo, Brazil |
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10:30 – 10:55 am |
State-of-the-Art: Regulation of Cell Death and Autophagy |
Hans-Uwe Simon, Switzerland |
10:55 – 11:15 am |
Cutting-Edge: Integration of Cytolysis and Autophagy in Eosinophils |
Stephane Esnault, USA |
11:15 – 11:35 am |
Cutting-Edge: Non-Canonical Siglec-8 Signaling Leading to Eosinophil Cell Death |
Jeremy O’Sullivan, USA |
11:35 – 11:55 am |
Cutting-Edge: Aggregated ETotic Eosinophils Characterize Airway Mucus Properties |
Shigeharu Ueki, Japan |
11:55 am – 12:15 pm |
Oral Abstract: Delineating Subtypes Of Murine Eosinophil Regulated Cell Death |
Immaculeta Osuji, USA |
12:15 – 12:30 pm |
Oral Abstract: Characteristics of Human Eosinophil ETosis In Vitro |
Hiroki Tomizawa, Japan |
12:30 – 4:00 pm |
Break |
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4:00 – 4:45 pm |
Paul Ehrlich Award LectureFrom Cell Adhesion and Migration to Siglecs and their Sialoglycan Ligands: My Career in Eosinophil Biology Chair: Judah Denburg, Canada |
Bruce Bochner, USA |
5:00 – 5:30 pm |
IES Business Meeting |
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5:40 - 6:00 pm
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Abstract Slams Session 1Chair: Allison Fryer, USA |
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5:40 pm - 5:43 pm |
Cell-death-induced Release of Eosinophil Sombrero Vesicles: A Cell-specific Type of Extracellular Vesicle? |
Vitor H. Neves, Brazil |
5:43 pm - 5:46 pm |
Colorectal Cancer Cells Induce a Unique Transcriptome Signature in Eosinophils and Primes Their Responses to IL-3-induced Activation |
Micahl Itan, Israel |
5:46 pm - 5:49 pm |
Targeting Interleukin-5/5R For The Treatment Of Idiopathic Chronic Eosinophilic Pneumonia |
Matthieu Groh, France |
5:49 pm - 5:52 pm |
Persistence of Symptomatic Flares and Neutrophil Cycling in a Clinical Trial of High-dose Mepolizumab Treatment for Episodic Angioedema with Eosinophilia |
Rodaba Rahim, USA |
5:52 pm - 5:55 pm |
Biomarkers Of T Cell Driven Disease And Treatment Responses In The 200622-205203 Clinical Trials Evaluating Efficacy and Safety Of Mepolizumab In Patients With Hypereosinophilic Syndrome |
Julien Catherine, Belgium |
5:55 pm - 5:58 pm |
Impact Of Doxycycline On Nasal Inflammation and Wound Healing After FESS Is Defined By CRS Endotype/Phenotype |
Elke Vandewalle, Belgium |
6:00 - 7:30 pm |
Poster Session ReceptionFood and drinks provided |
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6:00 - 7:30 pm |
Ask an Expert Poster Session 1 |
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Single Cell RNA Seq - Example from EoE study |
Netali Ben-Baruch Morgenstern, USA |
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Isolation and Functional Aspects of Eosinophil-Derived Exosomes |
Victoria Del Pozo, Spain |
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3 Dimensional Imaging of Tissue Eosinophils |
Allison Fryer, USA |
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Highly Multiplexed Imaging Using Iterative Bleaching Extends Multiplexity (IBEX): Considerations for Imaging Eosinophils |
Josh Koenig, Canada |
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High Throughput Vasculature Model for Toxicity Screening and Disease Modeling |
Boyang Zhang, Canada |
6:00 - 6:45 pm |
Poster Session 1 |
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Development of Novel Small Molecule Biased Antagonists Targeting CCR3 for Treatment of Eosinophil- and Other CCR3-associated Diseases |
Steven J. Ackerman, USA |
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In Cold Blood: A Toolkit To Study Eosinophils In Zebrafish |
Miriam Herbert, Germany |
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High-Dimension Flow Cytometry Resolves Human and Murine Eosinophilopoiesis and the Unique Dynamics of Eosinophilia |
Joseph Jorssen, Belgium |
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Human Hypereosinophilic Syndrome Affects Eosinophil Mitochondrial Dynamics Leading to Cristae Remodeling and Inter-organelle Contacts |
Cinthia Palazzi, Brazil |
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Adipose Tissue Eosinophils are Transcriptionally Distinct from Blood Eosinophils: Uncovering Anti-Obesity Targets |
Kate G. R. Quinlan, Australia |
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The Role of the Molecular Circadian Clock in Asthma |
Julia Teppan, Austria |
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Anti-Citrullinated Histone Monoclonal Antibody to Inhibit Release of Eosinophil Extracellular Traps |
Daphne Montizaan, Netherlands |
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New Insights into Eosinophil Granules and Mechanisms of Degranulation Revealed by Cryo-Electron Tomography (CryoET) |
Joshua M. Mitchell, USA |
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Molecular Anatomy of Eosinophil Activation by IL5 and IL33 |
Joshua M. Mitchell, USA |
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Characterization of Lung Eosinophil Subsets During Respiratory Viral Infection in Mice with Pre-Existing Immunity |
Lauren A. Chang, USA |
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Immunophenotyping of Circulating Eosinophils in Patients with Hypereosinophilic Syndrome |
Krishan D. Chhiba, USA |
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Raman Spectroscopy Identifies the Disease-related Eosinophils at a Single Cell Level |
Ji-Hyang Lee, Korea |
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Phenotype Profile of Circulating Eosinophils in Atopic Dermatitis |
Guillaume Lefèvre, France |
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Cytokine Signals Determine Eosinophil Phenotypes in Eosinophilic Esophagitis |
Andrea R. Szep, USA |
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Eosinophil Phenotypes and Receptor Expression on Circulating and Airway Eosinophils After Inhaled Allergen Challenge in Allergic Asthmatics |
Christiane Whetstone, Canada |
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Eosinophils Protect Against Esophageal Squamous Cell Carcinoma Due to Reactive Oxygen Species Released During Degranulation |
Yash Choksi, USA |
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IL-4, IL-33, IFN-gamma, TNF-alpha and GM-CSF Are Upstream Regulators Of The Transcriptional Activity Of Lung Metastasis-Entrained Eosinophil In Breast Cancer |
Inbal Hazut, Israel |
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Eosinophils Demonstrate Dynamic Shifts in Subset Dominance Throughout Progressive Stages of Colorectal Cancer |
Deeksha Raju, Switzerland |
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Mepolizumab Treatment-Failures in Two Patients with Lymphoid Variant Hypereosinophilic Syndrome |
Sina Karimi, Belgium |
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Design of a Phase 3 Study of Benralizumab in Bullous Pemphigoid (FJORD) |
Dagmar Simon, Switzerland |
6:45 - 7:30 pm |
Poster Session 2 |
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Generation of Eosinophils and Eosinophil Precursors From Induced Pluripotent Stem Cells |
Amy Klion, USA |
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Hypereosinophilic Syndrome Response to Mepolizumab in the Setting of a Compassionate Use Program |
Gauthier G. Coussement, Belgium |
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French Guidelines for the Etiological Workup of Eosinophilia and the Management of Hypereosinophilic Syndromes |
Matthieu Groh, France |
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Epidemiology, Clinical Presentation, and Outcomes of 620 Patients with Eosinophilia in the Intensive Care Unit |
Matthieu Groh, France |
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Reduced Mucous Plugging in the Small Airways of Chronic Obstructive Pulmonary Disease Patients with Eosinophilic Inflammation |
Andrew Higham, UK |
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Mogamulizumab for Refractory CD3-CD4+ Lymphocytic-Variant Hypereosinophilic Syndrome |
Emmanuel Ledoult, France |
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New Insights into Hypereosinophilia and Hypereosinophilic Syndromes Thanks to the First 551 Patients Included in the COHESion Study, a National Multicenter Cohort |
Guillaume Lefèvre, France |
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Are Pregnancy and Post-partum at Risk for Relapses and Obstetric Complications in HES and ANCA-Negative EGPA? |
Guillaume Lefèvre, France |
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Ex Vivo Assessment of the Stability Over Time of Surface Markers of Circulating Eosinophils in Patients with Atopic Dermatitis and Healthy Subjects |
Guillaume Lefèvre, France |
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A Single-Dose Weight-Based Challenge Predicts the Minimally Effective Daily Dose of Prednisone in Hypereosinophilic Syndromes |
Michelle A. Makiya, USA |
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A Phase 3 Study Evaluating the Efficacy and Safety of Benralizumab in Patients with Hypereosinophilic Syndrome |
Princess U. Ogbogu, USA |
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Circulating Eosinophil and Cytokine Levels in COVID Patients |
Maral Ranjbar, Canada |
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Dupilumab Reduces Exacerbations And Improves Lung Function In Children (6–11 Years) With Moderate-To-Severe Asthma And High Eosinophils |
Mena Soliman, Canada |
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Real-World Insights on the Burden of Hypereosinophilic Syndrome (HES) |
Jared Silver, USA |
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Relationship Between Type II Inflammation and Patient Reported Cough Severity and Quality of Life Outcomes in Subjects with Chronic Cough |
Yoshihisa Tokunaga, Canada |
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Deciphering the Role of Interleukin-5 in Eosinophil Biology in the Era of Targeted Therapies |
Glenn Van Hulst, Netherlands |
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Disease Characterization, Treatment Patterns, Clinical Outcomes, and Healthcare Resource Utilization of European Patients With HES Disease Subtypes |
Lee Baylis, USA |
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Country Differences in the Clinical Manifestations and Treatment Patterns of Patients with Eosinophilic Granulomatosis with Polyangiitis (EGPA): A European Perspective |
Lee Baylis, USA |
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Rationale and Design of the 52-Week, Randomized, Phase 3, Head-To-Head MANDARA Study to Evaluate the Safety and Efficacy of Benralizumab in Refractory or Relapsing Eosinophilic Granulomatosis with Polyangiitis |
Michael E. Wechsler, USA |
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Effect of Benralizumab on Eosinophil Levels in Skin of Patients with Moderate to Severe Atopic Dermatitis |
Christiane Whetstone, Canada |
7:30 pm |
Networking Event for Young Scientists |
Return to Symposium Homepage
7:00 - 8:00 am |
Breakfast Breakouts |
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Breakfast Breakout 4: NIAID Outreach for New/Young Investigators |
Patricia Fulkerson, USA |
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Breakfast Breakout 5: Mentorship to Success |
Steven Ackerman, USA |
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Breakfast Breakout 6: Industry and Industry Sponsored Research |
Calman Prussin, USA |
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Breakfast Breakout 7: Fundraising for Conferences |
Bruce Bochner, USA |
8:00 – 10:00 am |
Session 3: Eosinophils and Local Immunity- Interactions with Multiple Cell TypesChair: Hirohito Kita, USA & Imran Satia, Canada |
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8:00 – 8:25 am |
State-of-the-Art: Eosinophils and Control of Peripheral Nervous Systems |
Matthew Drake, USA |
8:25 – 8:50 am |
State-of-the-Art: Eosinophil Interactions with Mast Cells |
Francesca Levi-Schaffer, Israel |
8:50 – 9:10 am |
Cutting-Edge: Regulation of Eosinophils by ILC2 cells |
Roma Sehmi, Canada |
9:10 – 9:30 am |
Cutting-Edge: Eosinophil and IL-5 Regulation of Plasmacytoid Dendritic Cells |
Michelle Gill, USA |
9:30 – 9:45 am |
Oral Abstract: Adipose Eosinophils Are Transcriptionally Regulated By Activating Transcription Factor 3 (ATF3) And Promote Angiogenesis Via Vascular Endothelial Growth Factor A (VEGFA) |
Annalise M. Psaila, Australia |
9:45 – 10:00 am |
Oral Abstract: Parasympathetic Airway Hyperreactivity is Enhanced in Acute but Not Chronic Eosinophilic Asthma |
Aubrey B. Pierce, USA |
10:00 – 10:30 am |
Break |
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10:30 - 12:30 pm |
Session 4: Eosinophils in Host DefenseChair: Pedro Gazzinelli Guimaraes, USA |
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10:30 – 10:55 am |
State-of-the-Art: Eosinophils and Host Defense Against Parasites |
Pedro Gazzinelli Guimaraes, USA |
10:55 – 11:15 am |
Cutting-Edge: Eosinophils and Mycobacterium Tuberculosis Infection |
Katrin Mayer-Barber, USA |
11:15 – 11:35 am |
Cutting-Edge: Eosinophils and Influenza Infection |
Amali Samarasinghe, USA |
11:35 – 11:55 am |
Cutting-Edge: Eosinophils in the context of Aspergillus Fumigatus-Induced Lung Inflammation |
David Voehringer, Germany |
11:55 am – 12:10 pm |
Oral Abstract: Active Eosinophils Regulate Host Defense And Immune Responses In Colitis |
Alessandra Gurtner, Switzerland |
12:10 – 12:25 pm |
Oral Abstract: Eosinophil CD48 Interaction with Candida Albicans Als6 is Critical For Protective Responses During Systemic Candida Albicans Infection |
Ilan Zaffran, Israel |
12:30 – 4:00 pm |
Break / Optional Networking Event |
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4:00 – 6:00 pm |
Session 5: Reciprocal Interactions Between Eosinophils and Microbiomes in Homeostasis/DysbiosisChair: Glenn Furuta, USA & Tetsuo Shoda, USA |
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4:00 – 4:25 pm |
State-of-the-Art: Role of Esophageal Microbiome Homeostasis and Eosinophilic Inflammation |
Cathryn Nagler, USA |
4:25 – 4:45 pm |
Cutting-Edge: A Gut Commensal Protozoan Remotely Shapes a Lung Niche for Eosinophils and Tunes Pulmonary Immunity |
Kyle Burrows, Canada |
4:45 – 5:05 pm |
Cutting-Edge: Neonatal Eosinophils Shape the Intestinal Microbial Composition to Promote Immune Homeostasis and Commensalism |
Isabelle Arnold, Switzerland |
5:05 – 5:25 pm |
Cutting-Edge: Eosinophils and Microbial Signals in Asthma |
Donata Vercelli, USA |
5:25 – 5:40 pm |
Oral Abstract: Levels of MHCII+CD80+ Thymic Eosinophils Increase in Abundance During Neonatal Development in Mice and Their Accumulation is Microbiota-Dependent |
Dominique M. Gatti, Canada |
5:40 – 5:55 pm |
Oral Abstract: Dysbiotic Neonate Lung Microbial Communities Confer Neonate Responsiveness to Allergen and Development of Lung Eosinophilia: Machine-Learning for Prediction of Development of Eosinophilic Inflammation |
Joan M. Cook-Mills, USA |
6:10 - 6:25 pm
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Abstract Slams Session 2Chair: Mark Larché, Canada |
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6:10 pm - 6:13 pm |
Transcriptomic Analysis of the Acute Response to Local Esophageal Food Injections in Adult Patients with Eosinophilic Esophagitis |
Mirelle Kleuskens, Netherlands |
6:13 pm - 6:16 pm |
Charcot–Leyden Crystal Protein: Palmitoylation and Eosinophil Cytokine Secretion |
Haibin Wang, USA |
6:16 pm - 6:19 pm |
Eosinophil Depletion Can Decrease Inflammation and Can Be Used as a Therapeutic Target In Established Colitis Without Impacting Fibrosis |
Inge Jacobs, Belgium |
6:19 pm - 6:22 pm |
Non-epithelial Gene Expression Correlates with Symptom Severity in Adults with Eosinophilic Esophagitis |
Seung Kim, USA |
6:22 pm - 6:25 pm |
Machine Learning-Based Characterization of Esophageal Mast Cells in Eosinophilic Esophagitis |
Simin Zhang, USA |
6:30 - 8:00 pm |
Poster Session ReceptionFood and drinks provided |
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6:30 - 8:00 pm |
Ask an Expert Poster Session 2 |
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Generation of Eosinophils and Eosinophil Precursors From Induced Pluripotent Stem Cells |
Amy Klion, USA |
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Eosinophil Phosphoproteomics |
Joshua Mitchell, USA |
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How to Identify Resting and Activated Eosinophils with Transmission Electron Microscopy |
Vitor H. Neves, Brazil |
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3-D Models of Vasculitis |
Milica Radisic, Canada |
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Assessing Eosinophils and Eosinophil Activity on Ex Vivo Sputum Plugs |
Manali Mukherjee, Canada |
6:30 - 7:15 pm |
Poster Session 3 |
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In vivo Regulation of the Recruitment of Airway Eosinophils in Asthma to Antigen Challenge |
William W. Busse, USA |
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Tissue Adaptation of Eosinophils in the Intestine is Partially Controlled by the Aryl Hydrocarbon Receptor |
Nicola Diny, United Kingdom |
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Regulation of Cytokine Secretion by Eosinophils in the Epithelial Microenvironment |
Emily D. Gonzalez Galan, USA |
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Venous Thrombosis and Predictors of Relapse in Eosinophil-Related Diseases |
Matthieu Groh, France |
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Eosinophils Promote ILC2s in Allergic Respiratory Inflammation |
Elizabeth A. Jacobsen, USA |
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IL-4Ra Signaling Mediates Eosinophil-Sensory Neuron Crosstalk in Type 2 Inflammatory Skin Microenvironment |
Mithilesh K. Jha, USA |
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JAK Inhibition For CD3- CD4+ Lymphocytic-Variant Hypereosinophilic Syndrome |
Jean-Emmanuel Kahn, France |
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Macrophage Mediate Epithelial Cytoskeletal and Matrix Dysregulation in Fibrostenotic Eosinophilic Oesophagitis |
Joanne C. Masterson, Ireland |
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Diminished TLR3 Expression and Function in EoE-derived Esophageal Fibroblasts and Epithelial Cells |
Quan M. Nhu, USA |
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The Impact of Eosinophils on Airway Hyperresponsiveness in High-Fat Diet-Induced Obese Mice |
Zhenying Nie, USA |
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Effect of Intranasal Steroid on Cytokine Expression in the Nasal Lavage of Allergic Rhinitis Patients Before and after Nasal Allergen Challenge |
Hafsa Omer, Canada |
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Nerve Remodeling in a Mouse Model of Eosinophilic Esophagitis (EoE) |
Becky J. Proskocil, USA |
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TSLP Shapes Pathogenic Responses of Memory CD4+ T Cells in Eosinophilic Esophagitis |
Yrina Rochman, USA |
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Biological Treatment Induces a Transition from Eosinophilic to Neutrophilic Inflammation in CRSwNP Patients |
Sharon Van Nevel, Belgium |
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Eosinophils Respond to an Enteric Salmonella Typhimurium Infection in Mice |
Rachael D. FitzPatrick, Canada |
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Eosinophils Actively Migrate Within the Boundaries of Schistosoma Mansoni-induced Hepatic Granulomas |
Kássia K. Malta, Brazil |
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Candida Albicans-Induced Human Eosinophil Extracellular DNA Traps Release |
Josiane S. Neves, Brazil |
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Eosinophils as Predictors of Severe COVID-19 Patients Outcome: A Retrospective Study from Early Pandemic in Brazil |
Vitor H. Neves, Brazil |
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Uncovering the Role of Different Eosinophil Populations during Parasitic Nematode Infections |
Shashini K. Perera, Canada |
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The Role of Eosinophils in Immune Response to Mycobacterium Tuberculosis |
Maryonne Snow-Smith, USA |
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Relation Between Reduction in Fractional Exhaled Nitric Oxide And Efficacy in Patients With Asthma Treated with Dupilumab |
Mena Soliman, Canada |
7:15 - 8:00 pm |
Poster Session 4 |
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Dupilumab in Adolescent Eosinophilic Esophagitis: Early Experience with Step-Down Therapy, Fibro-Stenotic Phenotypes, and Eosinophilic Gastroenteritis |
Robert Becker, USA |
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Redefining Normal Eosinophil Counts: A Novel Standardized Approach to Histological Eosinophil Quantification |
Matthias Ceulemans, Belgium |
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Tissue-Specific Inducible Expression of IL-33 Elicits Features of Eosinophilic Esophagitis |
Alfred D. Doyle, USA |
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Experimental Eosinophilic Esophagitis is Accompanied with Increased Expression of TSLP and IL-33 |
Anish Dsilva, Israel |
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Esophageal Eosinophils Represent a Distinct Biosynthetic and Immunomodulatory Gastrointestinal Eosinophil Subset |
Jennifer M. Felton, USA |
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Monoacylglycerol Lipase Inhibition in Esophageal Epithelial Cells in Pathogenesis of Eosinophilic Esophagitis |
Eva Gruden, Austria |
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Multicolor Flow Cytometric Determination of Immune Cell Composition and Activation in Eosinophilic Esophagitis |
Melanie Kienzl, Austria |
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Mast Cells Disrupt the Function of the Esophageal Epithelial Barrier |
Mirelle Kleuskens, Netherlands |
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Dupilumab Improves Histological Outcomes and Normalizes Disease and Type 2 Inflammation Transcriptome Signatures in Adult and Adolescent Patients With Eosinophilic Oesophagitis: Results From the 3-Part Phase 3 LIBERTY EoE TREET Study |
Erika Martire, USA |
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High Prevalence of Response to PPI Treatment in Children and Adolescents with Eosinophilic Esophagitis in Southern Brazil |
Luiza S. Nader, Brazil |
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Eosinophil Granule Proteins Exhibit Different Deposition Patterns in Patients with Eosinophilic Esophagitis and Correlate with Basal Zone Hyperplasia |
Christopher D. Nazaroff, USA |
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Notch 2 Signaling in Eosinophils Partially Underlies Intestinal Tissue-Specific Adaptations |
Courtney L. Olbrich, USA |
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Proteomic Analysis of Eosinophilic Esophagitis: Identification and Involvement of the Minichromosome Maintenance Complex as a Driver of Esophageal Basal Zone Hyperplasia |
Mark Rochman, USA |
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Nuclear Circadian Receptors in Eosinophilic Esophagitis (EOE) |
Julia Teppan, Austria |
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Preliminary Transcriptomic Analysis of Moderate to Severe Eosinophilic Esophagitis Esophageal Tissue Pre- and Post-Eosinophil Depletion With Benralizumab: Results From The MESSINA Study |
Wendy I. White, USA |
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Triggering Receptor Expressed on Myeloid Cells-1 Promotes Allergic Airway Inflammation and Eosinophil Function |
Jayden Bowen, USA |
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E-cigarette Vapor Extract has a Substantial Effect on Human Eosinophil Transcription Mediated by Propylene Glycol and Glycerin |
Nicholas T. Hogan, USA |
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Single-cell RNA Sequencing of Human Eosinophils in Nasal Polyps Helps to Define Their Role in Chronic Rhinosinusitis |
Atsushi Kato, USA |
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Phenotype of Blood Eosinophils in DRESS Syndrome Compared with Drug-Induced Maculopapular Exanthema with or without Eosinophilia |
Guillaume Lefèvre, France |
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Automatic Quantification Method of Eosinophilic Degranulation in Tissues: Application for the Study of Eosinophilic Disorders |
Guillaume Lefèvre, France |
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The Functional Role of CD69 Expressed on Activated Eosinophils |
Yasutaka Yun, Japan |
Return to Symposium Homepage
7:00 am - 8:00 am |
Breakfast Breakouts |
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Breakfast Breakout 8: Transition to Academic Independence |
Jean Marshall, Canada |
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Breakfast Breakout 9: Strategies for Publishing in Impactful Journals |
Irving Allen, USA |
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Breakfast Breakout 10: Careers in Industry |
Christopher Nazaroff, USA |
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Breakfast Breakout 11: Women and Underrepresented Groups in Science |
Sonia Anand, Canada |
8:00 – 10:00 am |
Session 6: Eosinophils and Mast Cells in EGID – CEGIR-SponsoredChairs: Paul Moayyedi, Canada & Ignacio Gonzalez Perez, Switzerland |
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8:00 – 8:25 am |
State-of-the-Art: Regulation, Role and Plasticity of Eosinophils in EGID |
Marc Rothenberg, USA |
8:25 – 8:45 am |
Cutting-Edge: Role of Mast Cells in EoE and other EGIDs |
Joshua Wechsler, USA |
8:45 – 9:05 am |
Cutting-Edge: Natural History of and Targeted Treatment Options for EGID |
Glenn Furuta, USA |
9:05 – 9:25 am |
Cutting-Edge: The Role of Mast Cells in Eosinophilic Esophagitis Based on Single-Cell Analyses |
Netali Ben-Baruch Morgenstern, USA |
9:25 – 9:40 am |
Oral Abstract: IL-10 Controls Eosinophil Survival And Function In The Gastrointestinal Tract |
Ignacio Gonzalez Perez, Switzerland |
9:40 – 9:55 am |
Oral Abstract: A Novel Eosinophilic Esophagitis Murine Model Based on TSLP Overexpression Reveals a Proliferating Epithelial Phenotype |
Mario Alberto Ynga Durand, USA |
10:00 – 10:30 am |
Break |
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10:30 – 12:30 pm |
Session 7: Eosinophils in Tissue Injury and RepairChair: Kate G. R. Quinlan, Australia & Natalie Rhone, Israel |
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10:30 – 10:55 am |
State-of-the-Art: Remodeling and Fibrosis in Eosinophil Inflammation |
Seema Aceves, USA |
10:55 – 11:15 am |
Cutting-Edge: Eosinophils Promote Allograft Acceptance in Lung Transplantation |
Alexander Krupnick, USA |
11:15 – 11:35 am |
Cutting-Edge: Eosinophilic Fasciitis-Mouse Models |
Maxime Kinet, USA |
11:35 – 11:55 am |
Cutting-Edge: Differential Roles of Eosinophils in Cardiovascular Diseases |
Guo-Ping Shi, USA |
11:55 am – 12:10 pm |
Oral Abstract: Experimental Eosinophilic Esophagitis is Dependent on Eosinophils |
Natalie Rhone, Israel |
12:10 – 12:25 pm |
Oral Abstract: Hyperactive Eosinophils In The Postnatal Lung Impair Lung Development And Promote Persistent Lung Inflammation |
April L. Raftery, Australia |
12:45 – 1:45 pm |
Satellite Symposium: A Focus on Type 2 Inflammation in DiseaseThis is a non-CME event sponsored by Sanofi & Regeneron. |
William W. Busse, USA |
12:30 – 3:00 pm |
Break |
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3:00 – 4:30 pm |
Session 8: Eosinophils in Tumor Biology and Cancer TherapyChair: Isabelle Arnold, Switzerland |
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3:00 – 3:25 pm |
State-of-the-Art: Eosinophils in the Tumor Microenvironment: A Story of the Future from Past to Present |
Ariel Munitz, Israel |
3:25 – 3:45 pm |
Cutting-Edge: Eosinophil Collaborations with Innate Cells: On the Front Foot Against Cancer |
Gabrielle Belz, Australia |
3:45 – 4:00 pm |
Oral Abstract: Assessing the Roles of Eosinophils in the Tumor Microenvironment Using Spatial Transcriptomics |
Elizaveta Razvarina, Israel |
4:00 – 4:15 pm |
Oral Abstract: Phenotyping T Cells from Lymphocytic Variant Hypereosinophilic Syndrome Patients Identifies Cell Markers Associated with Different Clinical Profiles |
Charles Anderson, USA |
4:15 – 4:30 pm |
Oral Abstract: Long-Term Follow-up of Hypereosinophilic Syndrome Patients Treated With Mepolizumab: A Nationwide Real-Life Study Of 58 Patients |
Kevin Chevalier, France |
4:30 – 4:45 pm |
Break |
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4:45 – 5:45 pm
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Gerald J. Gleich Award LecturesChair: Florence Roufosse, Belgium |
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4:45 pm – 5:15 pm |
Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity |
Sharon Grisaru-Tal, Israel |
5:15 pm – 5:45 pm |
Eosinophils are an Essential Element of a Type 2 Immune Axis that Controls Thymus Regeneration |
Emilie Cosway, United Kingdom |
7:00 pm |
Networking Dinner and Awards CeremonyLiuna Station |
Return to Symposium Homepage
8:00 – 9:30 am |
Session 9: Eosinophils and the EpitheliumChair: Eva Gruden, Austria & Lisa Spencer, USA |
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8:00 – 8:25 am |
State-of-the-Art: Eosinophils in Chronic Rhinosinusitis |
Robert Schleimer, USA |
8:25 – 8:45 am |
Cutting-Edge: Bullous Pemphigoid |
Kyle Amber, USA |
8:45 – 9:05 am |
Cutting-Edge: TBD |
Aline Ignacio, Canada |
9:05 – 9:25 am |
Cutting-Edge: Eosinophils, Autoimmunity and Mucus Production |
Manali Mukherjee, Canada |
9:30 – 10:00 am |
Break |
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10:00 - 12:00 pm |
Session 10: Pro/Con Debates: What has Targeting Eosinophils with Biologics Taught Us?Chairs: Fei Li Kuang, USA and Judah Denburg, Canada |
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10:00 am – 11:00 am |
Targeting Eosinophils in Disease is Enough! |
Pro: Amy Klion, USA |
11:00 am – 12:00 pm |
Eosinophils are Dispensable! Pro: The Eosinophil Is Clearly Associated with Disease Activity but Likely not Important for Normal Human Health Con: TBD |
Pro: Gerald Gleich, USA |
12:00 – 1:00 pm |
Lunch - lunch boxes provided |
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1:00 – 2:30 pm |
Session 11: Roundtable Discussions |
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1:00 – 1:45 pm |
Topic 1: Are there Subtypes of Eosinophils? |
Facilitators: |
1:45 – 2:30 pm |
Topic 2: Clinical Biology of Eosinophils: The Future |
Facilitators: |
2:30 – 3:00 pm |
Closing RemarksJudah Denburg, Canada Florence Roufosse, Belgium |