International Eosinophil Society, Inc.

8:00 - 5:00 pm

Hypereosinophilic Syndrome Pre-Meeting Workshop:
Biologic Therapy in Eosinophil-Associated Disorders: Remaining Questions and Translational Research Opportunities

The Pre-Meeting Workshop is not included in the regular registration rate and can be added for an additional fee during the registration process.

8:00 - 10:00 am

Session I: Introduction 

8:00 - 8:15 am

Introductory Remarks

Amy Klion, USA

8:15 - 9:45 am

Multicenter Retrospective Analysis as a Tool for Rare Disease Research: Successes and Limitations  

Princess Ogbogu, USA

9:45 - 10:00 am

Retrospective Multicenter Study of Biologics in HES – Summary of Results and Remaining Questions

Bruce Bochner, USA

10:00 - 10:30 am

Coffee Break

10:30 - 12:00 pm

Session II: Biologics in Rare Eosinophil-Associated Diseases

10:30 - 11:00 am

Predictors of Response to Biologics in EAD

Florence Roufosse, Belgium

11:00 - 11:30 am

Safety Considerations

Fei Li Kuang, USA

11:30 - 12:00 pm

Biomarkers and Clinical Outcome Measures of Disease Activity in EAD

Praveen Akuthota, USA

12:00 - 12:45 pm

Lunch

12:45 - 3:00 pm

Session III: Approach to the Study of Biologics in EAD - Focus Groups

3:00 - 3:30 pm

Coffee Break

3:30 - 4:30 pm

Session IV: Conclusions and Future Directions

3:30 - 4:30 pm

Focus Group Presentations

4:30 - 5:00 pm

Summary and Action Items

Workshop Supporter

Grant Support

Funding for this workshop was made possible (in part) by support from NCATS. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the NIH; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S Government.

6:00 – 7:30 pm

Welcome to the 12th Biennial Symposium of the International Eosinophil Society

Chair: Mark Larché, Canada (Scientific Program Chair)

6:00 – 6:10 pm

Welcome from McMaster University

Paul O’Byrne, Canada

6:10 – 6:40 pm

Welcome Lecture: The Clinical Biology of Eosinophils: A Saga

Judah Denburg, Canada

6:45 – 7:15 pm

What have we Learned about Eosinophils and Eosinophilic Disorders from Eosinophil-Targeted Therapeutics

Gail Gauvreau, Canada

7:30 – 9:30 pm

Welcome Reception

Art Gallery of Hamilton

7:00 am - 8:00 am

Breakfast Breakouts

Breakfast Breakout 1: Roles in Academic Leadership

Allison Fryer, USA
Paul O'Byrne, Canada

Breakfast Breakout 2: Career Progression in the World of Eosinophils

Fei Li Kuang, USA
Manali Mukherjee, Canada

Breakfast Breakout 3:  Alternate Non-Academic Career Paths

Claudia Hui, Canada 
Dan Moldaver, Canada

8:00 – 10:00 am

Session 1: Regulation of Eosinophil Development

Chairs: Sergejs Berdnikovs, USA & Zhenying (Jane) Nie, USA

8:00 – 8:25 am

State-of-the-Art: 'Haeckel'ing Evolution of Eosinophils and Function: "Ontogeny Recapitulates Phylogeny"…or Does It?

Steven Ackerman, USA

8:25 – 8:45 am

Cutting-Edge: Metabolic Reprogramming and Stromal Support in Generation of Long-Lived Eosinophils

Sergejs Berdnikovs, USA

8:45 – 9:05 am

Cutting-Edge: Myeloid Progenitor Differentiation Pathways Identified through scRNAseq

Claus Nerlov, UK

9:05 – 9:25 am

Cutting-Edge: Expanding Landscape of Myeloid Neoplasms with Gene Rearrangement and Eosinophilia

Nives Zimmermann, USA

9:25 – 9:40 am

Oral Abstract: Single-Cell RNAseq Reveals Transcriptional Heterogeneity Of Eosinophils And Basophils In Human Blood

Irene Whitney, USA

9:40 – 9:55 am

Oral Abstract: IRF1 is a Major Regulatory Transcription Factor for Immune Responses in Eosinophils

Elizabeth A. Jacobsen, USA

10:00 – 10:30 am

Break

10:30 - 12:30 pm

Session 2: Cell Death (and Stress, Autophagy) in Eosinophil Biology

Chairs: Jennifer M. Felton, USA &  Rossana Melo, Brazil

10:30 – 10:55 am

State-of-the-Art: Regulation of Cell Death and Autophagy

Hans-Uwe Simon, Switzerland

10:55 – 11:15 am

Cutting-Edge: Integration of Cytolysis and Autophagy in Eosinophils

Stephane Esnault, USA

11:15 – 11:35 am

Cutting-Edge: Non-Canonical Siglec-8 Signaling Leading to Eosinophil Cell Death

Jeremy O’Sullivan, USA

11:35 – 11:55 am

Cutting-Edge: Aggregated ETotic Eosinophils Characterize Airway Mucus Properties

Shigeharu Ueki, Japan

11:55 am – 12:15 pm

Oral Abstract:  Delineating Subtypes Of Murine Eosinophil Regulated Cell Death

Immaculeta Osuji, USA

12:15 – 12:30 pm

Oral Abstract: Characteristics of Human Eosinophil ETosis In Vitro

Hiroki Tomizawa, Japan

12:30 – 4:00 pm

Break

4:00 – 4:45 pm

Paul Ehrlich Award Lecture

From Cell Adhesion and Migration to Siglecs and their Sialoglycan Ligands:  My Career in Eosinophil Biology

Chair: Judah Denburg, Canada

Bruce Bochner, USA

5:00 – 5:30 pm

IES Business Meeting

5:40 - 6:00 pm

Abstract Slams Session 1

Chair: Allison Fryer, USA

5:40 pm - 5:43 pm

Cell-death-induced Release of Eosinophil Sombrero Vesicles: A Cell-specific Type of Extracellular Vesicle?

Vitor H. Neves, Brazil

5:43 pm - 5:46 pm

Colorectal Cancer Cells Induce a Unique Transcriptome Signature in Eosinophils and Primes Their Responses to IL-3-induced Activation

Micahl Itan, Israel

5:46 pm - 5:49 pm

Targeting Interleukin-5/5R For The Treatment Of Idiopathic Chronic Eosinophilic Pneumonia

Matthieu Groh, France

5:49 pm - 5:52 pm

Persistence of Symptomatic Flares and Neutrophil Cycling in a Clinical Trial of High-dose Mepolizumab Treatment for Episodic Angioedema with Eosinophilia

Rodaba Rahim, USA

5:52 pm - 5:55 pm

Biomarkers Of T Cell Driven Disease And Treatment Responses In The 200622-205203 Clinical Trials Evaluating Efficacy and Safety Of Mepolizumab In Patients With Hypereosinophilic Syndrome

Julien Catherine, Belgium

5:55 pm - 5:58 pm

Impact Of Doxycycline On Nasal Inflammation and Wound Healing After FESS Is Defined By CRS Endotype/Phenotype

Elke Vandewalle, Belgium

6:00 - 7:30 pm

Poster Session Reception

Food and drinks provided

6:00 - 7:30 pm

Ask an Expert Poster Session 1

Single Cell RNA Seq - Example from EoE study

Netali Ben-Baruch Morgenstern, USA 

Isolation and Functional Aspects of Eosinophil-Derived Exosomes 

Victoria Del Pozo, Spain 

3 Dimensional Imaging of Tissue Eosinophils

Allison Fryer, USA 

Highly Multiplexed Imaging Using Iterative Bleaching Extends Multiplexity (IBEX): Considerations for Imaging Eosinophils

Josh Koenig, Canada 

High Throughput Vasculature Model for Toxicity Screening and Disease Modeling

Boyang Zhang, Canada

6:00 - 6:45 pm

Poster Session 1

Development of Novel Small Molecule Biased Antagonists Targeting CCR3 for Treatment of Eosinophil- and Other CCR3-associated Diseases

Steven J. Ackerman, USA

In Cold Blood: A Toolkit To Study Eosinophils In Zebrafish

Miriam Herbert, Germany

High-Dimension Flow Cytometry Resolves Human and Murine Eosinophilopoiesis and the Unique Dynamics of Eosinophilia

Joseph Jorssen, Belgium

Human Hypereosinophilic Syndrome Affects Eosinophil Mitochondrial Dynamics Leading to Cristae Remodeling and Inter-organelle Contacts

Cinthia Palazzi, Brazil

Adipose Tissue Eosinophils are Transcriptionally Distinct from Blood Eosinophils: Uncovering Anti-Obesity Targets

Kate G. R. Quinlan,  Australia

The Role of the Molecular Circadian Clock in Asthma

Julia Teppan, Austria

Anti-Citrullinated Histone Monoclonal Antibody to Inhibit Release of Eosinophil Extracellular Traps

Daphne Montizaan, Netherlands

New Insights into Eosinophil Granules and Mechanisms of Degranulation Revealed by Cryo-Electron Tomography (CryoET)

Joshua M. Mitchell, USA

Molecular Anatomy of Eosinophil Activation by IL5 and IL33 

Joshua M. Mitchell, USA

Characterization of Lung Eosinophil Subsets During Respiratory Viral Infection in Mice with Pre-Existing Immunity

Lauren A. Chang, USA

Immunophenotyping of Circulating Eosinophils in Patients with Hypereosinophilic Syndrome

Krishan D. Chhiba, USA

Raman Spectroscopy Identifies the Disease-related Eosinophils at a Single Cell Level

Ji-Hyang Lee, Korea

Phenotype Profile of Circulating Eosinophils in Atopic Dermatitis

Guillaume Lefèvre, France

Cytokine Signals Determine Eosinophil Phenotypes in Eosinophilic Esophagitis

Andrea R. Szep, USA

Eosinophil Phenotypes and Receptor Expression on Circulating and Airway Eosinophils After Inhaled Allergen Challenge in Allergic Asthmatics

Christiane Whetstone, Canada

Eosinophils Protect Against Esophageal Squamous Cell Carcinoma Due to Reactive Oxygen Species Released During Degranulation

Yash Choksi, USA

IL-4, IL-33, IFN-gamma, TNF-alpha and GM-CSF Are Upstream Regulators Of The Transcriptional Activity Of Lung Metastasis-Entrained Eosinophil In Breast Cancer

Inbal Hazut, Israel

Eosinophils Demonstrate Dynamic Shifts in Subset Dominance Throughout Progressive Stages of Colorectal Cancer

Deeksha Raju, Switzerland

Mepolizumab Treatment-Failures in Two Patients with Lymphoid Variant Hypereosinophilic Syndrome

Sina Karimi, Belgium

Design of a Phase 3 Study of Benralizumab in Bullous Pemphigoid (FJORD)

Dagmar Simon, Switzerland

6:45 - 7:30 pm

Poster Session 2

Generation of Eosinophils and Eosinophil Precursors From Induced Pluripotent Stem Cells

Amy Klion, USA

Hypereosinophilic Syndrome Response to Mepolizumab in the Setting of a Compassionate Use Program

Gauthier G. Coussement, Belgium

French Guidelines for the Etiological Workup of Eosinophilia and the Management of Hypereosinophilic Syndromes

Matthieu Groh, France

Epidemiology, Clinical Presentation, and Outcomes of 620 Patients with Eosinophilia in the Intensive Care Unit

Matthieu Groh, France

Reduced Mucous Plugging in the Small Airways of Chronic Obstructive Pulmonary Disease Patients with Eosinophilic Inflammation

Andrew Higham, UK

Mogamulizumab for Refractory CD3-CD4+ Lymphocytic-Variant Hypereosinophilic Syndrome

Emmanuel Ledoult, France

New Insights into Hypereosinophilia and Hypereosinophilic Syndromes Thanks to the First 551 Patients Included in the COHESion Study, a National Multicenter Cohort

Guillaume Lefèvre, France

Are Pregnancy and Post-partum at Risk for Relapses and Obstetric Complications in HES and ANCA-Negative EGPA?

Guillaume Lefèvre, France

Ex Vivo Assessment of the Stability Over Time of Surface Markers of Circulating Eosinophils in Patients with Atopic Dermatitis and Healthy Subjects

Guillaume Lefèvre, France

A Single-Dose Weight-Based Challenge Predicts the Minimally Effective Daily Dose of Prednisone in Hypereosinophilic Syndromes

Michelle A. Makiya, USA

A Phase 3 Study Evaluating the Efficacy and Safety of Benralizumab in Patients with Hypereosinophilic Syndrome

Princess U. Ogbogu, USA

Circulating Eosinophil and Cytokine Levels in COVID Patients

Maral Ranjbar, Canada

Dupilumab Reduces Exacerbations And Improves Lung Function In Children (6–11 Years) With Moderate-To-Severe Asthma And High Eosinophils

Mena Soliman, Canada

Real-World Insights on the Burden of Hypereosinophilic Syndrome (HES)

Jared Silver, USA

Relationship Between Type II Inflammation and Patient Reported Cough Severity and Quality of Life Outcomes in Subjects with Chronic Cough

Yoshihisa Tokunaga, Canada

Deciphering the Role of Interleukin-5 in Eosinophil Biology in the Era of Targeted Therapies

Glenn Van Hulst, Netherlands

Disease Characterization, Treatment Patterns, Clinical Outcomes, and Healthcare Resource Utilization of European Patients With HES Disease Subtypes

Lee Baylis, USA

Country Differences in the Clinical Manifestations and Treatment Patterns of Patients with Eosinophilic Granulomatosis with Polyangiitis (EGPA): A European Perspective

Lee Baylis, USA

Rationale and Design of the 52-Week, Randomized, Phase 3, Head-To-Head MANDARA Study to Evaluate the Safety and Efficacy of Benralizumab in Refractory or Relapsing Eosinophilic Granulomatosis with Polyangiitis

Michael E. Wechsler, USA

Effect of Benralizumab on Eosinophil Levels in Skin of Patients with Moderate to Severe Atopic Dermatitis

Christiane Whetstone, Canada

7:30 pm

Networking Event for Young Scientists

7:00 - 8:00 am

Breakfast Breakouts

Breakfast Breakout 4:  NIAID Outreach for New/Young Investigators

Patricia Fulkerson, USA 
Mike Minnicozzi, USA 

Breakfast Breakout 5:  Mentorship to Success

Steven Ackerman, USA
Dagmar Simon, Switzerland

Breakfast Breakout 6:  Industry and Industry Sponsored Research

Calman Prussin, USA 
Florence Roufosse, Belgium

Breakfast Breakout 7:  Fundraising for Conferences

Bruce Bochner, USA  
William W. Busse, USA
Allison Fryer, USA

8:00 – 10:00 am

Session 3: Eosinophils and Local Immunity- Interactions with Multiple Cell Types

Chair: Hirohito Kita, USA & Imran Satia, Canada

8:00 – 8:25 am

State-of-the-Art: Eosinophils and Control of Peripheral Nervous Systems

Matthew Drake, USA

8:25 – 8:50 am

State-of-the-Art: Eosinophil Interactions with Mast Cells

Francesca Levi-Schaffer, Israel

8:50 – 9:10 am

Cutting-Edge: Regulation of Eosinophils by ILC2 cells

Roma Sehmi, Canada

9:10 – 9:30 am

Cutting-Edge: Eosinophil and IL-5 Regulation of Plasmacytoid Dendritic Cells

Michelle Gill, USA

9:30 – 9:45 am

Oral Abstract: Adipose Eosinophils Are Transcriptionally Regulated By Activating Transcription Factor 3 (ATF3) And Promote Angiogenesis Via Vascular Endothelial Growth Factor A (VEGFA)

Annalise M. Psaila, Australia

9:45 – 10:00 am

Oral Abstract: Parasympathetic Airway Hyperreactivity is Enhanced in Acute but Not Chronic Eosinophilic Asthma

Aubrey B. Pierce, USA

10:00 – 10:30 am

Break

10:30 - 12:30 pm

Session 4: Eosinophils in Host Defense

Chair: Pedro Gazzinelli Guimaraes, USA

10:30 – 10:55 am

State-of-the-Art: Eosinophils and Host Defense Against Parasites

Pedro Gazzinelli Guimaraes, USA

10:55 – 11:15 am

Cutting-Edge: Eosinophils and Mycobacterium Tuberculosis Infection

Katrin Mayer-Barber, USA

11:15 – 11:35 am

Cutting-Edge: Eosinophils and Influenza Infection

Amali Samarasinghe, USA

11:35 – 11:55 am

Cutting-Edge: Eosinophils in the context of Aspergillus Fumigatus-Induced Lung Inflammation

David Voehringer, Germany 

11:55 am – 12:10 pm

Oral Abstract: Active Eosinophils Regulate Host Defense And Immune Responses In Colitis

Alessandra Gurtner, Switzerland

12:10 – 12:25 pm

Oral Abstract: Eosinophil CD48 Interaction with Candida Albicans Als6 is Critical For Protective Responses During Systemic Candida Albicans Infection

Ilan Zaffran, Israel

12:30 – 4:00 pm

Break / Optional Networking Event

4:00 – 6:00 pm

Session 5: Reciprocal Interactions Between Eosinophils and Microbiomes in Homeostasis/Dysbiosis

Chair: Glenn Furuta, USA & Tetsuo Shoda, USA

4:00 – 4:25 pm

State-of-the-Art: Role of Esophageal Microbiome Homeostasis and Eosinophilic Inflammation

Cathryn Nagler, USA

4:25 – 4:45 pm

Cutting-Edge: A Gut Commensal Protozoan Remotely Shapes a Lung Niche for Eosinophils and Tunes Pulmonary Immunity

Kyle Burrows, Canada

4:45 – 5:05 pm

Cutting-Edge: Neonatal Eosinophils Shape the Intestinal Microbial Composition to Promote Immune Homeostasis and Commensalism

Isabelle Arnold, Switzerland

5:05 – 5:25 pm

Cutting-Edge: Eosinophils and Microbial Signals in Asthma

Donata Vercelli, USA

5:25 – 5:40 pm

Oral Abstract:  Levels of MHCII+CD80+ Thymic Eosinophils Increase in Abundance During Neonatal Development in Mice and Their Accumulation is Microbiota-Dependent 

Dominique M. Gatti, Canada

5:40 – 5:55 pm

Oral Abstract: Dysbiotic Neonate Lung Microbial Communities Confer Neonate Responsiveness to Allergen and Development of Lung Eosinophilia: Machine-Learning for Prediction of Development of Eosinophilic Inflammation

Joan M. Cook-Mills, USA

6:10 - 6:25 pm

Abstract Slams Session 2

Chair: Mark Larché, Canada

6:10 pm - 6:13 pm

Transcriptomic Analysis of the Acute Response to Local Esophageal Food Injections in Adult Patients with Eosinophilic Esophagitis

Mirelle Kleuskens, Netherlands

6:13 pm - 6:16 pm

Charcot–Leyden Crystal Protein: Palmitoylation and Eosinophil Cytokine Secretion

Haibin Wang, USA

6:16 pm - 6:19 pm

Eosinophil Depletion Can Decrease Inflammation and Can Be Used as a Therapeutic Target In Established Colitis Without Impacting Fibrosis

Inge Jacobs, Belgium

6:19 pm - 6:22 pm

Non-epithelial Gene Expression Correlates with Symptom Severity in Adults with Eosinophilic Esophagitis

Seung Kim, USA

6:22 pm - 6:25 pm

Machine Learning-Based Characterization of Esophageal Mast Cells in Eosinophilic Esophagitis

Simin Zhang, USA

6:30 - 8:00 pm

Poster Session Reception

Food and drinks provided

6:30 - 8:00 pm

Ask an Expert Poster Session 2

Generation of Eosinophils and Eosinophil Precursors From Induced Pluripotent Stem Cells

Amy Klion, USA

Eosinophil Phosphoproteomics

Joshua Mitchell, USA

How to Identify Resting and Activated Eosinophils with Transmission Electron Microscopy

Vitor H. Neves, Brazil 

3-D Models of Vasculitis

Milica Radisic, Canada

Assessing Eosinophils and Eosinophil Activity on Ex Vivo Sputum Plugs

Manali Mukherjee, Canada

6:30 - 7:15 pm

Poster Session 3

In vivo Regulation of the Recruitment of Airway Eosinophils in Asthma to Antigen Challenge

William W. Busse, USA

Tissue Adaptation of Eosinophils in the Intestine is Partially Controlled by the Aryl Hydrocarbon Receptor

Nicola Diny, United Kingdom

Regulation of Cytokine Secretion by Eosinophils in the Epithelial Microenvironment

Emily D. Gonzalez Galan, USA

Venous Thrombosis and Predictors of Relapse in Eosinophil-Related Diseases

Matthieu Groh, France

Eosinophils Promote ILC2s in Allergic Respiratory Inflammation

Elizabeth A. Jacobsen, USA

IL-4Ra Signaling Mediates Eosinophil-Sensory Neuron Crosstalk in Type 2 Inflammatory Skin Microenvironment

Mithilesh K. Jha, USA

JAK Inhibition For CD3- CD4+ Lymphocytic-Variant Hypereosinophilic Syndrome

Jean-Emmanuel Kahn, France

Macrophage Mediate Epithelial Cytoskeletal and Matrix Dysregulation in Fibrostenotic Eosinophilic Oesophagitis

Joanne C. Masterson, Ireland

Diminished TLR3 Expression and Function in EoE-derived Esophageal Fibroblasts and Epithelial Cells

Quan M. Nhu, USA

The Impact of Eosinophils on Airway Hyperresponsiveness in High-Fat Diet-Induced Obese Mice

Zhenying Nie, USA

Effect of Intranasal Steroid on Cytokine Expression in the Nasal Lavage of Allergic Rhinitis Patients Before and after Nasal Allergen Challenge

Hafsa Omer, Canada

Nerve Remodeling in a Mouse Model of Eosinophilic Esophagitis (EoE)

Becky J. Proskocil, USA

TSLP Shapes Pathogenic Responses of Memory CD4+ T Cells in Eosinophilic Esophagitis

Yrina Rochman, USA

Biological Treatment Induces a Transition from Eosinophilic to Neutrophilic Inflammation in CRSwNP Patients

Sharon Van Nevel, Belgium

Eosinophils Respond to an Enteric Salmonella Typhimurium Infection in Mice

Rachael D. FitzPatrick, Canada

Eosinophils Actively Migrate Within the Boundaries of Schistosoma Mansoni-induced Hepatic Granulomas

Kássia K. Malta, Brazil

Candida Albicans-Induced Human Eosinophil Extracellular DNA Traps Release

Josiane S. Neves, Brazil

Eosinophils as Predictors of Severe COVID-19 Patients Outcome: A Retrospective Study from Early Pandemic in Brazil

Vitor H. Neves, Brazil

Uncovering the Role of Different Eosinophil Populations during Parasitic Nematode Infections

Shashini K. Perera, Canada

The Role of Eosinophils in Immune Response to Mycobacterium Tuberculosis

Maryonne Snow-Smith, USA

Relation Between Reduction in Fractional Exhaled Nitric Oxide And Efficacy in Patients With Asthma Treated with Dupilumab

Mena Soliman, Canada

7:15 - 8:00 pm

Poster Session 4

Dupilumab in Adolescent Eosinophilic Esophagitis: Early Experience with Step-Down Therapy, Fibro-Stenotic Phenotypes, and Eosinophilic Gastroenteritis

Robert Becker, USA

Redefining Normal Eosinophil Counts: A Novel Standardized Approach to Histological Eosinophil Quantification

Matthias Ceulemans, Belgium

Tissue-Specific Inducible Expression of IL-33 Elicits Features of Eosinophilic Esophagitis

Alfred D. Doyle, USA

Experimental Eosinophilic Esophagitis is Accompanied with Increased Expression of TSLP and IL-33

Anish Dsilva, Israel

Esophageal Eosinophils Represent a Distinct Biosynthetic and Immunomodulatory Gastrointestinal Eosinophil Subset

Jennifer M. Felton, USA

Monoacylglycerol Lipase Inhibition in Esophageal Epithelial Cells in Pathogenesis of Eosinophilic Esophagitis

Eva Gruden, Austria

Multicolor Flow Cytometric Determination of Immune Cell Composition and Activation in Eosinophilic Esophagitis

Melanie Kienzl, Austria

Mast Cells Disrupt the Function of the Esophageal Epithelial Barrier

Mirelle Kleuskens, Netherlands

Dupilumab Improves Histological Outcomes and Normalizes Disease and Type 2 Inflammation Transcriptome Signatures in Adult and Adolescent Patients With Eosinophilic Oesophagitis: Results From the 3-Part Phase 3 LIBERTY EoE TREET Study

Erika Martire, USA

High Prevalence of Response to PPI Treatment in Children and Adolescents with Eosinophilic Esophagitis in Southern Brazil

Luiza S. Nader, Brazil

Eosinophil Granule Proteins Exhibit Different Deposition Patterns in Patients with Eosinophilic Esophagitis and Correlate with Basal Zone Hyperplasia

Christopher D. Nazaroff, USA

Notch 2 Signaling in Eosinophils Partially Underlies Intestinal Tissue-Specific Adaptations

Courtney L. Olbrich, USA

Proteomic Analysis of Eosinophilic Esophagitis: Identification and Involvement of the Minichromosome Maintenance Complex as a Driver of Esophageal Basal Zone Hyperplasia

Mark Rochman, USA

Nuclear Circadian Receptors in Eosinophilic Esophagitis (EOE)

Julia Teppan, Austria

Preliminary Transcriptomic Analysis of Moderate to Severe Eosinophilic Esophagitis Esophageal Tissue Pre- and Post-Eosinophil Depletion With Benralizumab: Results From The MESSINA Study

Wendy I. White, USA

Triggering Receptor Expressed on Myeloid Cells-1 Promotes Allergic Airway Inflammation and Eosinophil Function

Jayden Bowen, USA

E-cigarette Vapor Extract has a Substantial Effect on Human Eosinophil Transcription Mediated by Propylene Glycol and Glycerin

Nicholas T. Hogan, USA

Single-cell RNA Sequencing of Human Eosinophils in Nasal Polyps Helps to Define Their Role in Chronic Rhinosinusitis

Atsushi Kato, USA

Phenotype of Blood Eosinophils in DRESS Syndrome Compared with Drug-Induced Maculopapular Exanthema with or without Eosinophilia

Guillaume Lefèvre, France

Automatic Quantification Method of Eosinophilic Degranulation in Tissues: Application for the Study of Eosinophilic Disorders

Guillaume Lefèvre, France

The Functional Role of CD69 Expressed on Activated Eosinophils

Yasutaka Yun, Japan

7:00 am - 8:00 am

Breakfast Breakouts

Breakfast Breakout 8: Transition to Academic Independence

Jean Marshall, Canada 
Lisa Spencer, USA

Breakfast Breakout 9: Strategies for Publishing in Impactful Journals

Irving Allen, USA
Paul Moayyedi, Canada 
Marc Rothenberg, USA  

Breakfast Breakout 10: Careers in Industry

Christopher Nazaroff, USA
Brad Youngblood, USA

Breakfast Breakout 11: Women and Underrepresented Groups in Science

Sonia Anand, Canada
Amali Samarasinghe, USA

8:00 – 10:00 am

Session 6: Eosinophils and Mast Cells in EGID – CEGIR-Sponsored

Chairs: Paul Moayyedi, Canada & Ignacio Gonzalez Perez, Switzerland

8:00 – 8:25 am

State-of-the-Art: Regulation, Role and Plasticity of Eosinophils in EGID

Marc Rothenberg, USA

8:25 – 8:45 am

Cutting-Edge: Role of Mast Cells in EoE and other EGIDs

Joshua Wechsler, USA

8:45 – 9:05 am

Cutting-Edge: Natural History of and Targeted Treatment Options for EGID

Glenn Furuta, USA

9:05 – 9:25 am

Cutting-Edge: The Role of Mast Cells in Eosinophilic Esophagitis Based on Single-Cell Analyses

Netali Ben-Baruch Morgenstern, USA

9:25 – 9:40 am

Oral Abstract: IL-10 Controls Eosinophil Survival And Function In The Gastrointestinal Tract

Ignacio Gonzalez Perez, Switzerland

9:40 – 9:55 am

Oral Abstract: A Novel Eosinophilic Esophagitis Murine Model Based on TSLP Overexpression Reveals a Proliferating Epithelial Phenotype

Mario Alberto Ynga Durand, USA

10:00 – 10:30 am

Break

10:30 – 12:30 pm

Session 7: Eosinophils in Tissue Injury and Repair

Chair: Kate G. R. Quinlan, Australia & Natalie Rhone, Israel

10:30 – 10:55 am

State-of-the-Art: Remodeling and Fibrosis in Eosinophil Inflammation

Seema Aceves, USA

10:55 – 11:15 am

Cutting-Edge: Eosinophils Promote Allograft Acceptance in Lung Transplantation

Alexander Krupnick, USA

11:15 – 11:35 am

Cutting-Edge: Eosinophilic Fasciitis-Mouse Models

Maxime Kinet, USA

11:35 – 11:55 am

Cutting-Edge:  Differential Roles of Eosinophils in Cardiovascular Diseases

Guo-Ping Shi, USA

11:55 am – 12:10 pm

Oral Abstract: Experimental Eosinophilic Esophagitis is Dependent on Eosinophils

Natalie Rhone, Israel

12:10 – 12:25 pm

Oral Abstract:  Hyperactive Eosinophils In The Postnatal Lung Impair Lung Development And Promote Persistent Lung Inflammation

April L. Raftery, Australia

12:45 – 1:45 pm

Satellite Symposium: A Focus on Type 2 Inflammation in Disease

This is a non-CME event sponsored by Sanofi & Regeneron.
Lunch will be provided.

William W. Busse, USA

12:30 – 3:00 pm

Break

3:00 – 4:30 pm

Session 8: Eosinophils in Tumor Biology and Cancer Therapy

Chair: Isabelle Arnold, Switzerland

3:00 – 3:25 pm

State-of-the-Art: Eosinophils in the Tumor Microenvironment: A Story of the Future from Past to Present

Ariel Munitz, Israel

3:25 – 3:45 pm

Cutting-Edge: Eosinophil Collaborations with Innate Cells: On the Front Foot Against Cancer

Gabrielle Belz, Australia

3:45 – 4:00 pm

Oral Abstract: Assessing the Roles of Eosinophils in the Tumor Microenvironment Using Spatial Transcriptomics

Elizaveta Razvarina, Israel

4:00 – 4:15 pm

Oral Abstract: Phenotyping T Cells from Lymphocytic Variant Hypereosinophilic Syndrome Patients Identifies Cell Markers Associated with Different Clinical Profiles

Charles Anderson, USA

4:15 – 4:30 pm

Oral Abstract: Long-Term Follow-up of Hypereosinophilic Syndrome Patients Treated With Mepolizumab:  A Nationwide Real-Life Study Of 58 Patients

Kevin Chevalier, France

4:30 – 4:45 pm

Break

4:45 – 5:45 pm

Gerald J. Gleich Award Lectures

Chair: Florence Roufosse, Belgium

4:45 pm – 5:15 pm

Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity

Sharon Grisaru-Tal, Israel

5:15 pm – 5:45 pm

Eosinophils are an Essential Element of a Type 2 Immune Axis that Controls Thymus Regeneration

Emilie Cosway, United Kingdom

7:00 pm

Networking Dinner and Awards Ceremony

Liuna Station

8:00 – 9:30 am

Session 9: Eosinophils and the Epithelium

Chair: Eva Gruden, Austria & Lisa Spencer, USA 

8:00 – 8:25 am

State-of-the-Art: Eosinophils in Chronic Rhinosinusitis

Robert Schleimer, USA

8:25 – 8:45 am

Cutting-Edge: Bullous Pemphigoid

Kyle Amber, USA

8:45 – 9:05 am

Cutting-Edge: TBD

Aline Ignacio, Canada

9:05 – 9:25 am

Cutting-Edge: Eosinophils, Autoimmunity and Mucus Production

Manali Mukherjee, Canada

9:30 – 10:00 am

Break

10:00 - 12:00 pm

Session 10: Pro/Con Debates: What has Targeting Eosinophils with Biologics Taught Us?

Chairs: Fei Li Kuang, USA and Judah Denburg, Canada

10:00 am – 11:00 am

Targeting Eosinophils in Disease is Enough!

Pro: Amy Klion, USA
Con: Peter Weller, USA

11:00 am – 12:00 pm

Eosinophils are Dispensable!

Pro: The Eosinophil Is Clearly Associated with Disease Activity but Likely not Important for Normal Human Health

Con: TBD

Pro: Gerald Gleich, USA
Con: Elizabeth Jacobsen, USA

12:00 – 1:00 pm

Lunch - lunch boxes provided

1:00 – 2:30 pm

Session 11: Roundtable Discussions

1:00 – 1:45 pm

Topic 1: Are there Subtypes of Eosinophils?

Facilitators:
Mats Johansson, USA
Lisa Spencer, USA

1:45 – 2:30 pm

Topic 2: Clinical Biology of Eosinophils: The Future

Facilitators:
Praveen Akuthota, USA
Paneez Khoury, USA

2:30 – 3:00 pm

Closing Remarks

Judah Denburg, Canada

Florence Roufosse, Belgium