International Eosinophil Society, Inc.

6:00 – 7:15 pm

Welcome to the 12th Biennial Symposium of the International Eosinophil Society

Chair: Mark Larché, Canada (Scientific Program Chair)

6:00 – 6:10 pm

Welcome from McMaster University

Paul O’Byrne, Canada

6:10 – 6:40 pm

Welcome Lecture: The Clinical Biology of Eosinophils: A Saga

Judah Denburg, Canada

6:45 – 7:15 pm

What have we Learned about Eosinophils and Eosinophilic Disorders from Eosinophil-Targeted Therapeutics

Gail Gauvreau, Canada

7:30 – 9:30 pm

Welcome Reception

Art Gallery of Hamilton

7:00 – 8:00 am

8:00 – 10:00 am

Breakfast with an Expert

Session 1: Regulation of Eosinophil Development

8:00 – 8:25 am

State-of-the-Art: 'Haeckel'ing Evolution of Eosinophils and Function: "Ontogeny Recapitulates Phylogeny"…or Does It?

Steven Ackerman, USA

8:25 – 8:45 am

Cutting-Edge: Metabolic Reprogramming and Stromal Support in Generation of Long-Lived Eosinophils

Sergejs Berdnikovs, USA

8:45 – 9:05 am

Cutting-Edge: Myeloid Progenitor Differentiation Pathways Identified through scRNAseq

Claus Nerlov, UK

9:05 – 9:25 am

Cutting-Edge: Expanding Landscape of Myeloid Neoplasms with Gene Rearrangement and Eosinophilia

Nives Zimmermann, USA

9:25 – 9:40 am

Oral Abstract Presentation

9:40 – 9:55 am

Oral Abstract Presentation

10:00 – 10:30 am

Break

10:30 - 12:30 pm

Session 2: Cell Death (and Stress, Autophagy) in Eosinophil Biology

10:30 – 10:55 am

State-of-the-Art: Regulation of Cell Death and Autophagy

Hans-Uwe Simon, Switzerland

10:55 – 11:15 am

Cutting-Edge: Integration of Cytolysis and Autophagy in Eosinophils

Stephane Esnault, USA

11:15 – 11:35 am

Cutting-Edge: Non-Canonical Siglec-8 Signaling to Eosinophil Cell Death

Jeremy O’Sullivan, USA

11:35 – 11:55 am

Cutting-Edge: Eosinophil Extracellular Traps and Immunothrombosis in EGPA

Shigeharu Ueki, Japan

11:55 am – 12:15 pm

Oral Abstract Presentation

12:15 – 12:30 pm

Oral Abstract Presentation

12:30 – 1:00 pm

IES Business Meeting

1:00 – 4:00 pm

Break

4:00 – 5:00 pm

Paul Ehrlich Award Lecture

5:00 – 7:00 pm

Poster Session 1

7:15 pm

Networking Event for Young Scientists

7:00 – 8:00 am

Breakfast with an Expert

8:00 – 10:00 am

Session 3: Eosinophils and Local Immunity- Interactions with Multiple Cell Types

8:00 – 8:25 am

State-of-the-Art: Eosinophils and Control of Peripheral Nervous Systems

Matthew Drake, USA

8:25 – 8:50 am

State-of-the-Art: Eosinophil Interactions with Mast Cells

Francesca Levi-Schaffer, Israel

8:50 – 9:10 am

Cutting-Edge: Regulation of Eosinophils by ILC2 cells

Roma Sehmi, Canada

9:10 – 9:30 am

Cutting-Edge: Eosinophil and IL-5 Regulation of Plasmacytoid Dendritic Cells

Michelle Gill, USA

9:30 – 9:45 am

Oral Abstract Presentation

9:45 – 10:00 am

Oral Abstract Presentation

10:00 – 10:30 am

Break

10:30 - 12:30 pm

Session 4: Eosinophils in Host Defense

10:30 – 10:55 am

State-of-the-Art: Eosinophils and Host Defense Against Parasites

De’Broski Herbert, USA

10:55 – 11:15 am

Cutting-Edge: Eosinophils and Mycobacterium Tuberculosis Infection

Katrin Mayer-Barber, USA

11:15 – 11:35 am

Cutting-Edge: Eosinophils and Influenza Infection

Amali Samarasinghe, USA

11:35 – 11:55 am

Cutting-Edge: Eosinophils in the context of Aspergillus Fumigatus-Induced Lung Inflammation

David Voehringer, Germany 

11:55 am – 12:10 pm

Oral Abstract Presentation

12:10 – 12:25 pm

Oral Abstract Presentation

12:30 – 3:30 pm

Break / Optional Networking Event

3:30 – 5:30 pm

Session 5: Reciprocal Interactions Between Eosinophils and Microbiomes in Homeostasis/Dysbiosis

3:30 – 3:55 pm

State-of-the-Art: Role of Esophageal Microbiome Homeostasis and Eosinophilic Inflammation

Cathryn Nagler, USA

3:55 – 4:15 pm

Cutting-Edge: A Gut Commensal Protozoa Remotely Shapes a Lung Niche for Asthma Promoting Eosinophils

Arthur Mortha, Canada

4:15 – 4:35 pm

Cutting-Edge: Intestinal Eosinophil Heterogeneity, Specialization and Microbial Regulation

Isabelle Arnold, Switzerland

4:35 – 4:55 pm

Cutting-Edge: Eosinophils and Microbial Signals in Asthma

Donata Vercelli, USA

4:55 – 5:10 pm

Oral Abstract Presentation

5:10 – 5:25 pm

Oral Abstract Presentation

5:30 – 7:30 pm

Poster Session 2

7:00 – 8:00 am

Breakfast with an Expert

8:00 – 10:00 am

Session 6: Eosinophils and Mast Cells in EGID – CEGIR-Sponsored

8:00 – 8:25 am

State-of-the-Art: Regulation, Role and Plasticity of Eosinophils in EGID

Marc Rothenberg, USA

8:25 – 8:45 am

Cutting-Edge: Role of Mast Cells in EoE and other EGIDs

Joshua Wechsler, USA

8:45 – 9:05 am

Cutting-Edge: Natural History of and Targeted Treatment Options for EGID

Glenn Furuta, USA

9:05 – 9:25 am

Cutting-Edge: The Role of Mast Cells in Eosinophilic Esophagitis Based on Single-Cell Analyses

Netali Ben-Baruch Morgenstern, USA

9:25 – 9:40 am

Oral Abstract Presentation

9:40 – 9:55 am

Oral Abstract Presentation

10:00 – 10:30 am

Break

10:30 – 12:30 pm

Session 7: Eosinophils in Tissue Injury and Repair

10:30 – 10:55 am

State-of-the-Art: Remodeling and Fibrosis in Eosinophil Inflammation

Seema Aceves, USA

10:55 – 11:15 am

Cutting-Edge: Eosinophils Promote Allograft Acceptance in Lung Transplantation

Alex Mei, USA

11:15 – 11:35 am

Cutting-Edge: Eosinophilic Fasciitis-Mouse Models

Maxime Kinet, USA

11:35 – 11:55 am

Cutting-Edge: Eosinophils Protect and Improve Cardiac Function

Guo-Ping Shi, USA

11:55 am – 12:10 pm

Oral Abstract Presentation

12:10 – 12:25 pm

Oral Abstract Presentation

12:30 – 3:00 pm

Break

3:00 – 5:00 pm

Session 8: Eosinophils in Tumor Biology and Cancer Therapy

3:00 – 3:25 pm

State-of-the-Art: The Multifaceted Roles of Eosinophils in the Tumor Microenvironment and Following Cancer Immunotherapy

Ariel Munitz, Israel

3:25 – 3:45 pm

Cutting-Edge: The GM-CSF–IRF5 Signaling Axis in Eosinophils Promotes Antitumor Immunity

TBA

3:45 – 4:05 pm

Cutting-Edge: Eosinophilic Inflammation Promotes CCL6-Dependent Metastatic Tumor Growth

TBA

4:05 – 4:25 pm

Cutting-Edge: Eosinophil Collaborations with Innate Cells: On the Front Foot Against Cancer

Gabrielle Belz, Australia

4:25 – 4:40 pm

Oral Abstract Presentation

4:40 – 4:55 pm

Oral Abstract Presentation

5:00 – 5:15 pm

Break

5:15 – 6:15 pm

Gerald J. Gleich Award Lectures

5:15 pm – 5:45 pm

Eosinophils are an Essential Element of a Type 2 Immune Axis that Controls Thymus Regeneration

Emilie Cosway, United Kingdom

5:45 pm – 6:15 pm

Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity

Sharon Grisaru-Tal, Israel

7:00 pm

Networking Dinner and Award Ceremony

Liuna Station

8:00 – 9:25 am

Session 9: Eosinophils and the Epithelium

8:00 – 8:25 am

State-of-the-Art: Eosinophils in Chronic Rhinosinusitis

Bob Schleimer, USA

8:25 – 8:45 am

Cutting-Edge: Bullous Pemphigoid

Kyle Amber, USA

8:45 – 9:05 am

Cutting-Edge: IgE Autoantibodies in Severe Chronic Spontaneous Urticaria and Atopic Dermatitis

TBA

9:05 – 9:25 am

Cutting-Edge: Eosinophils, Autoimmunity and Mucus Production

Manali Mukherjee, Canada

9:30 – 10:00 am

Break

10:00 - 12:00 pm

Session 10: Pro/Con Debates: What has Targeting Eosinophils with Biologics Taught Us?

10:00 am – 11:00 am

Targeting Eosinophils in Disease is Enough!

Pro: Amy Klion, USA
Con: Peter Weller, USA

11:00 am – 12:00 pm

Eosinophils are Dispensable!

Pro: Gerald Gleich, USA
Con: Elizabeth Jacobsen, USA

12:00 – 1:00 pm

Lunch

1:00 – 2:30 pm

Session 11: Roundtable Discussions

1:00 – 1:45 pm

Topic 1: Are there Subtypes of Eosinophils?

Facilitators:
Mats Johansson (USA)
TBA

1:45 – 2:30 pm

Topic 2: Clinical Biology of Eosinophils:
Facilitators: TBA

Facilitators:
Praveen Akuthota (USA)
Paneez Khoury (USA)

2:30 – 3:00 pm

Closing Remarks

Florence Roufosse, Belgium