Scientific Program
The initial schedule for the 2019 IES Symposium is listed below.
IES Scientific Program
Tuesday 9 July
Welcome Reception (Portland Marriott Downtown Waterfront)
18:00 - 18:30 Welcome -
Bruce Bochner, USA & Allison Fryer, USA
18:30 - 19:00 History of Eosinophil Discovery or Why Did Eosinophils Capture My Attention - Jerry Gleich, USA
19:00 - 21:00 Welcome Reception
Wednesday 10 July
07:00 - 08:00 Breakfast with a Mentor Session: How to Navigate a Scientific Conference - Jackie Wirz, USA
Session 1: Eosinophils Across Species, What Does That Tell Us About Their Physiological Role, Evolution and Choice of Animal Models
08:15 - 08:45 On the Origin of Eosinophils by Means of Natural Selection: Preservation of a Favored Leukocyte in the Struggle for Life - Steve Ackerman, USA
08:45 - 09:15 Eosinophils and Disease Models from Mouse to Man: We are Stronger Together - Helene Rosenberg, USA
09:15 - 09:45 Eosinophil Identity in the Tissue Contexts of Development, Homeostasis, and Disease - Sergejs Berdnikovs, USA
Abstract Presentations
09:45 - 10:00 Real-Time in Vivo Imaging of Tissue Resident Eosinophils Under Homeostatic and Inflammatory Conditions - Kamala D. Patel, Canada
10:00 - 10:30 Morning Break
Session 2: Eosinophil Life Cycle, Hematopoiesis and Recruitment, Activation and Death
10:30 - 11:00 Hemopoietic Mechanisms in Eosinophilic Inflammation - Roma Sehmi, Canada
11:00 - 11:30 Eosinophils in Liver Death - Todd Davidson, USA
11:30 - 12:00 Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation - Shigeharu Ueki, Japan
12:00 - 12:30 Eosinophil Shape Change and Granule Secretion - Paige Lacy, Canada
12:30 - 13:00 IES Business Meeting
13:00 - 14:30 Lunch (on your own)
14:30 - 15:30 Gleich Award Winner Lecture -
Eosinophil Depletion Suppresses Radiation-Induced Small Intestinal Fibrosis - Naoki Takemura, Japan
15:30 - 16:00 Eosinophil Extracellular DNA Traps in Skin Diseases - Dagmar Simon, Switzerland
Abstract Presentations
16:00 - 16:15 First Ultrastructural Demonstration of Galectin-10 in Resting and Activated Human Eosinophils - Rossana Melo, Brazil
16:15 - 16:30 SIGLEC-8 Signals Through an Unanticipated Set of Molecules to Induce Integrin Upregulation and Activation, ROS Production, and Cell Death in Eosinophils - Jeremy O'Sullivan, USA
17:00 - 19:00 Poster Session 1
Poster 1 - Eosinophil Infiltration Does Not Exacerbate Muscle Pathology in the MDX Mouse Model of Duchenne Muscular Dystrophy - Albert Sek
Poster 3 - In Vitro and In Vivo Inhibition of Eosinophil Activation by Lysophosphatidylcholine and Synthetic Alkyl-Lysophosphatidylcholine - Eva Knuplez
Poster 5 - Characterizing SIGLECF+GR1- and SIGLECF+GR1+ Mouse Bone Marrow-Derived Eosinophils (bmEos) Cultured Ex Vivo - Eric Mai
Poster 9 - Nasal Polyps as a Presenting Sign of Systemic Eosinophilic Diseases - Yossi Rosman
Poster 11 - Dexpramipexole Responsiveness is increased in Eosinophilic Patients - Calman Prussin
Poster 13 - Single Site, Five-Year Experience with Human Eosinophil Isolation by Density Gradient Centrifugation and Immunomagnetic Negative Separation - Yun Cao
Poster 15 - Genetic Variation in Surfactant Protein-A2 and the Effect on Eosinophil Resolution in Allergic Airways - Alane Blythe C. Dy
Poster 17 - Eosinophil Cytolysis on IGG Requires Microtubule Array Formation, and P-38 Phosphorylation Downstream of Reactive Oxygen Species Production - Stephane Esnault
Poster 19 - IL-9 and IL-13 Storage and Release from Eosinophils - Sarah Almas
Poster 21 - The Role of Eosinophils in Obesity-Related Asthma - Gina Calco
Poster 23 - Kinetic Studies of Galectin-10 Release From Eosinophils to Proliferating T Cells - Christine Lingblom
Poster 25 - Eosinophil Responses to IL-4, IL-33 and Bacteria are Differentially Regulated by Apoptotic Cells - Avishay Dolitzky
Poster 27 - Harnessing Hymenolepis Diminuta Extract to Active Anti-Tumorigenic Activities of Eosinophils in Colorectal Cancer - Inbal Hazot
Poster 29 - Granulocyte Kinetics in the Blood and Sputum of Patients with Eosinophilic and Neutrophilic Inflammation - Leo Koenderman
Poster 31 - IGG4-Related Disease and Hypereosinophilic Syndrome: Overlapping Phenotypes? - Matthieu Groh
Poster 33 - Allergic Bronchopulmonary Aspergillosis as a Complication of COPD: A New Entity? - Matthieu Groh
Poster 35 - Intrinsic Sex-Specific Differences in Fibrotic Gene Expression and Pathology Contribute To Male Disease Predisposition in Pediatric Eosinophilic Esophagitis - Loan Duong
Poster 37 - Urine Levels Of Eosinophil Granule Proteins; A Better Biomarker of Eosinophilic Disease Activity? - Michelle Makiya
Poster 39 - Fluid Shear Stress Induces Rapid Actin Rearrangement in Eosinophils - Kiho Son
Poster 41 - Kruppel-Like Factor 3 (KLF3) Regulates Adipose Tissue Beiging via Eosinophils - Emily Vohralik
Poster 43 - Association of Blood Eosinophil Phenotypes and Patient Self-Assessment Data with Response to Treatment in Eosinophilic Esophagitis - Sofie Albinsson
Poster 45 - Eosinophilic Gastrointestinal Disease Treatment Approaches are Associated with Frequency of Feelings of Isolation - Elizabeth Jensen
Poster 47 - Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared To Common Beta-Chain Cytokines IL-5 and GM-CSF - Praveen Akuthota
Poster 49 - Eosinophils Suppress TH1 Responses and Restrict Bacterially Induced Gastrointestinal Inflammation - Isabelle Arnold
Poster 51 - Clinical and Endoscopic Features of the Fibrostenotic Phenotype in Eosinophilic Esophogitis - Paul Fichtinger
Poster 53 - Molecular, Endoscopic, Histological and Circulating Biomarker-Based Diagnosis of Eosinophilic Gastritis: Cross Sectional Multi-Site Study - Tetsuo Shoda
Poster 55 - Eosinophils are Present in Human and Mouse ESCC Tumors and May Be Protective in Tumorigenesis - Yash Choksi
Poster 57 - Eosinophils Alter Steady-State Small Intestinal IL-1α and IL-1ß Levels but are not Required for the Maintenance of Secretory IGA nor for Control of an Enteric Bacterial Pathogen - Rachael Brown
Poster 59 - Transgenic Expression of a Novel Secreted Active Form of IL-33 Promotes Eosinophilia in a Mouse Model of Eosinophilic Esophagitis - Benjamin Wright
Poster 61 - Hypereosinophilia Associated with Clonal CD3-CD4+ T Cells: Characterization and Outcome of a New Cohort of Patients - Sylvain Verbanck
Poster 63 - CD200R1 is Upregulated in the Esophageal Epithelium in Eosinophilic Esophagitis - Netali Ben Baruch-Morgenstern
Poster 65 - Eosinophil Subtype Specific Metabolic Activities - Elizabeth Jacobsen
Poster 67 - Eosinophils Modulate ILC2 Activities - Elizabeth Jacobsen
Poster 69 - Inhibition of Eosinophil Transendothelial Migration by 5HTP Stimulation of HTR1A and HTR1B in Endothelial Cells - Joan Cook-Mills
Poster 71 PIN1 Regulates IL-5 Induced Eosinophil Polarization and Migration - Zhong-Jian Shen
Poster 73 Adipose Tissue Eosinophils in Cancer-Associated Cachexia - Patrick Lenehan
Poster 75 Pharmacodynamic And Clinical Efficacy Data from Patient Sputum Subgroups in DREAM Treated with Mepolizumab Across A 10-fold Dose Range - Charlene Prazma
Poster 77 Palmitoylation of Galectin-10 in Human Eosinophils - Haibin Wang
Thursday 11 July
07:00 - 08:00 Breakfast with a Mentor Session: How NIH Supports Clinical Trials - Lisa Wheatley, USA
07:00 - 08:00 Breakfast with a Mentor Session: Program Officers, Study Sections, RFA and PAs: Learn the language, protocols and best practices to interact with the NIH - Michael Minnicozzi, USA
Session 3: Eosinophils and Host Defense
08:00 - 08:30 When Eosinophils Meet Viruses - Amali Samarasinghe, USA
08:30 - 09:00 Eosinophils Suppress Th1 Responses and Restrict Bacterially Induced Gastrointestinal Inflammation - Isabelle Arnold, Switzerland
09:00 - 09:30 Eosinophil Phenotypes in Immune Pathways - Elizabeth Jacobsen, USA
Abstract Presentations
09:30 - 09:45 Single Cell RNA Sequencing of Inflammatory Tissue T Cells in Eosinophilic Esophagitis - Ting Wen, USA
09:45 - 10:00 Identification of Eosinophil-Specific Gene-Enhancer Regions - Jennifer Felton, USA
10:00 - 10:30 Morning Break
Session 4: Eosinophils and Nerves
10:30 - 11:00 Maternal Inflammation and Offspring Eosinophils Regulate Airway Nerve Development - Katie Lebold, USA
11:00 - 11:30 Eosinophils Promote Sensory Nerve Growth in Human Asthma - Matthew Drake, USA
11:30 - 12:00 Eosinophils and Itch - David Jacoby, USA
Abstract Presentations
12:00 - 12:15 Asthma is Associated With Brain Neurodegeneration: A Possible Effect of Eosinophilic Inflammation? - William Busse, USA
12:15 - 12:30 Characterization of a Mouse Model of Heart Disease in Hypereosinophilia - Nives Zimmermann, USA
12:30 - 15:00 Lunch (on your own)
Session 5: Eosinophils and Metabolic Disease
15:00 - 15:30 Extreme IL-33-Dependent Eosinophil Accumulation in Adipose Tissue - Alyssa Hasty, USA
Abstract Presentations
15:30 - 15:45 The Role of Adipose Tissue-Resident Eosinophils in Adipocyte Metabolism and Whole-Body Energy Homeostasis - Elena Anna De Filippis, USA
15:45 - 16:00 Eosinophils in Beige Adipose Tissue Activation - Kate Quinlan, Australia
16:00 - 17:00 Ehrlich Award Winner Lecture - Regulation and Control of Eosinophilia - Marc Rothenberg, USA
17:00 - 19:00 Poster Session 2
Poster 2 - Eosinophils from Normal Donors How Do They Vary? How Do They Define Us? - Caroline Percopo
Poster 4 - Determining the Role of Eotaxin-1 in Eosinophil Development In Order To Promote Heterogeneity via an Ex Vivo Cuture System - Ajinkya Limkar
Poster 6 - Eosinophilia and Hookworm Infection: A Living Drug for Autoimmune Diseases - David Pritchard
Poster 8 - Sustained Long-Term Efficacy and Safety of RPC4046, an Anti-Interleukin-13 Monoclonal Antibody, In Patients with Eosinophilic Esophagitis: Results from the Open-Label Extension of the Heroes Study - Dianne Nguyen
Poster 10 - Markers of Esophageal Epithelial-Mesenchymal Transition (EMT) are Significantly Reduced in Active Eosinophilic Esophagitis Following 16 Weeks of Treatment with RPC4046, an Anti-Interleukin-13 Monoclonal Antibody - Dianne Nguyen
Poster 12 - Differentiation and Activation of Eosinophils in the Human Bone Marrow at Steady State and During Experimental Acute Systemic Inflammation - Marwan Hassani
Poster 14 - Activated Eosinophils Promote an Anti-Tumorigenic Environment in Tumor Models of Colorectal Cancer - Melanie Kienzl
Poster 16 - Vitamin Deficiencies May Vary in Relation to Symptoms and Treatment Approaches for Eosinophilic Esophagitis - Elizabeth Jensen
Poster 18 - Epidermal Expression of Eotaxins-1, 2, and 3 in Bullous Pemphigoid is Comparable to Other Eosinophil Rich Dermatoses: A Retrospective Immunohistochemical Analysis - Kyle Amber
Poster 20 - Detection of Eosinophil Cytolytic Degranulation in Paraffin-Embedded Tissue - Mineyo Fukuchi
Poster 22 - Human Eosinophils Express of Free Fatty Acid Receptor 2 And 3: Possible Implication of These Receptors in Interleukin-4 Production by Short Chain Fatty Acids - Myeong Seong Sim
Poster 24 - Intraesophageal Adminisration of Oxazolon to Skin-Sensitized? Mice Results In Experimental Eosinophilic Esophagitis - Shmuel Avlas
Poster 28 - Regulation of Eosinophil Recruitment in Allergic Airway Inflammation by Tropomyosin Receptor Kinase A - Mythili Dileepan
Poster 30 - Aspergillus Fumigatus-Induced Human Eosinophil Extracellular DNA Traps: Role of IP3K, p38 MAPK and Src Family - Marina Barroso
Poster 32 - Improved Diagnosis of Asthma: Metabolomic Profiling of Urine - Darryl Adamko
Poster 34 - AKST4290, a CCR3 Inhibitor, Is Efficacious In Models of Age-Related Eosinophilic Disorders - Arnaud Teichert
Poster 36 - The TNF Superfamily Member 14 (TNFSF14/Light) Induces Pro-Inflammatory Responses in Fibroblasts in Eosinophilic Esophagitis - Mario Manresa
Poster 38 - Lysophosphatidylserine Induces Eosinophil Extracellular Trap Cell Death - Hye Jeong Kim
Poster 40 - The Thiazolidinediones as Potential Therapeutic Agents for Eosinophilic Esophagitis Pathologic Remodeling: A Preclinical Evaluation - Quan Nhu
Poster 42 - Serum Eotaxin-1/CCL11 Levels Are Elevated in Severe Forms of Systemic Sclerosis - Guillaume Lefèvre
Poster 44 - A Functional Role for Eosinophils in Host Resistance against Mycobacterium Tuberculosis - Katrin Mayer-Barber
Poster 46 - Identification of Reactive Oxygen Species Production Site in Siglec-8 Induced Eosinophil Death - Toshihiro Tomii
Poster 48 - Efficacy and Tolerance of Interferon-Alpha in Hypereosinophilic Syndromes. A Retrospective, Multicenter Study on 29 Patients - Jean Emmanuel Kahn
Poster 50 - Eosinophil Subsets in Pediatric Exacerbation-Prone Asthma - Li Merlin
Poster 52 - Eosinophil Associated Type-2 Gene Expression in Childhood Asthma - Matthew Altman
Poster 54 - Improvement in Quality Of Life (QOL) In Pediatric Patients with Eosinophilc Esophagitis and Food Allergy after Initial Clinic Evaluation - Vibha Szafron
Poster 56 - IL-33 Expression and Potential Activation of Eosinophils Is Associated with ORMDL3 - Elizabeth Mckernan
Poster 58 - Quantifying Mucosal Eosinophilic Inflammation in EOE Using the 1-Hour Esophageal String Test - Milica Grozdanovic
Poster 60 - Elevated Serum Tarc in Patients with Idiopathic Hypereosinophilic Syndrome: A Marker of Lymphocyte- Driven Disease? - Julien Catherine
Poster 62 - IL-13 Treated Esophageal Epithelial Cells Induce Eosinophil Survival and Activation - Julia Dunn
Poster 64 - Effects of Sustained Eosinophil Depletion in Humans - Fei Li Kuang
Poster 66 - Expression and Function of Type 1 and Type 2 Eosinophils - Elizabeth Jacobsen
Poster 68 - Eosinophils Suppress Lung Allograft Rejection - Elizabeth Jacobsen
Poster 70 - Early Life Represents a Vulnerable Time Window for IL-33-Induced Lung Pathology - Hirohito Kita
Poster 72 Multiple Roles of PIN1 in the Regulation of TLR7 Signaling in Eosinophils - Zhong-Jian Shen
Poster 74 Steroid Dose Reducing Effect of Benralizumab, a Monoclonal Antibody to IL-5Ra, In Eosinophilic Granulomatosis with Polyangiitis - Vamsi P. Guntur
Poster 76 Oral Corticosteroid Dose Modulation in Severe Asthma: Impact on Peripheral Blood Eosinophil Count - Charlene Prazma
Poster 78 Eosinophils Dampen Hepatic Ischemia Reperfusion Injury through Interleukine-33 Signaling - Jong-Min Jeong
Friday 12 July
Session 6: Eosinophils in Chronic Inflammatory Disease - Asthma
08:00 - 08:30 ASTHMA - Autoimmune Responses, Eosinophils and Complex Airway Disease - Manali Mukherjee, Canada
08:30 - 09:00 ASTHMA - Anti IL5 Therapies for Severe Asthma: Targeting The Ligand vs The Receptor - Parameswaran Nair, Canada
09:00 - 09:30 LUNG - Targeting Eosinophils in Eosinophil Granulomatosis with Polyangitis - Michael E. Wechsler, USA
Abstract Presentations
09:30 - 09:45 Lung Eosinophils Increase Vagus Nerve Mediated Airway Reflex Bronchoconstriction in Mice - Zhenying Nie, USA
09:45 - 10:00 Idiopathic Eosinophilic Vasculitis, Another Side of Hypereosinophilic Syndrome? A Comprehensive Analysis of 115 Cases in Asthma-Free and ANCA-Negative Patients - Guillaume Lefèvre, France
10:00 - 10:30 Morning Break
Session 7: Eosinophils in Chronic Inflammatory Disease- GI
10:30 - 11:00 ESOPHAGUS - Eosinophilic Esophagitis-like Disease: Description of a New Disease Entity – Hans-Uwe Simon, Switzerland
11:00 - 11:30 GI OR SUBSETS - Phenotypically Distinct Subsets of Eosinophils Resident in Intestine - Lisa Spencer, USA
11:30 - 12:00 GI - Markers of Chronic Inflammatory Bowel Disease - Marie Carlson, Sweden
12:00 - 12:30 GI and SKIN - A Pathophysiological Potpourri of Conundrums and Challenges in Eosinophil-Related Epithelial Inflammation - Kristin Leiferman, USA
Abstract Presentations
12:30 - 12:45 Functional Role of Kallikrein 5 and Proteinase Activated Receptor (PAR)2 in Eosinophilic Esophagitis - Nurit Azouz, USA
12:45 - 13:00 Efficacy of RPC4046, An Anti-Interleukin-13 Monoclonal Antibody, In Patients with Active Eosinophilic Eosphagitis: Analysis of the Steroid-Refractory Subgroup From the Heroes Study - Dianne Nguyen, USA
13:00 - 15:00 Lunch (on your own)
13:00 - 15:00 CEGIR Lecture Session - "Findings from the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)"
- Introduction and Structure of CEGIR - Marc Rothenberg, United States
- Early Findings from the CEGIR EGID Observational Cohort - Ikuo Hirano, United States
- Partnering with Patients - Seema Aceves, Untied States and Representatives from PAGS
- Logistical Operations-Publications and Data Sharing - Sandeep Gupta, United States
- Training the Next Generation of EGID Leaders - Quan Nhu, United States
- NIAID Interests and Roles in Disease Consortia - Lisa Wheatley, United States and Mike Minnicozzi, United States
- Questions and Answers and Discussion
(lunch available for purchase during registration)
Session 8: Eosinophils in Cancer
15:00 - 15:30 Activated Eosinophils Exert Distinct Anti-Tumorigenic Activities in Colorectal Cancer - Ariel Munitz, Israel
15:30 - 16:00 Charcot-Leyden Crystals as a Drugable Target in Type 2 Immunity - Bart Lambrecht, United States
Abstract Presentations
16:00 - 16:15 Eosinophils Promote GM-CSF-Dependent Anti-Tumor Immunity Through Activation of Type I T-Cell Responses - Alessandra Gurtner, Switzerland
16:15 - 16:30 Activated Eosinophil Subsets are an Integral Part of the Tumor Microenvironment in Lung Metastasis, Displaying Anti-Tumorigenic Activities - Sharon Grisaru, Israel
Saturday 13 July
Session 9: The Now and Future of Eosinophils as a Drug Target
08:00 - 08:30 “Siglec”ting the Allergic Response for Therapeutic Targeting - Bruce Bochner, USA
08:30 - 09:00 Developing Dexpramipexole for the Treatment of Eosinophilic Disorders - Calman Prussin, USA
09:00 - 09:30 Subtypes of Responders to Treatment in Hypereosinophilic Syndrome - Paneez Khoury, USA
09:30 - 10:00 Eosinophil Depletion in Humans: Is It Safe? - Amy Klion, USA
10:00 - 10:30 EOS, Exacerbations and Adherence…The Good, Bad and Ugly of Severe Asthma - Richard Costello, Ireland
Abstract Presentation
10:30 - 10:45 Alpha IIb Integrin (CD41) on Blood Eosinophils is a Potential Biomarker for Disease Activity in Eosinophilic Esophagitis (EoE) - Mats Johansson, USA
10:45 - 11:15 Morning Break
11:15 - 12:15 Roundtable Discussion 1 - New Emerging or Controversial Topics - Is There More Than One Type of Eosinophil?
12:15 - 13:15 Roundtable Discussion 2 - New Emerging or Controversial Topics - Eosinophils-What are They Good For?
