Hans-Uwe Simon, MD, PhD
Institute of Pharmacology, University of Bern, Bern, Switzerland
We are interested in pathogenic mechanisms involved in eosinophilic diseases. Projects range between basic science questions and investigator-driven drug studies. Currently, besides molecular mechanisms of eosinophilia, we are particularly interested in the role of autophagy for eosinophil functions as well as in mechanisms of eosinophil-mediated tissue damage.
Apoptosis, autophagy, atopic dermatitis, eosinophils, eosinophilic esophagitis, hypereosinophilic syndrome
H.-U. Simon, S.G. Plötz, R. Dummer, K. Blaser: Abnormal clones of T cells producing interleukin 5 in idiopathic eosinophilia. N. Engl. J. Med. 341(1999), 1112-1120.
S. Yousefi, J.A. Gold, N. Andina, J.J. Lee, A.M. Kelly, E. Kozlowski, I. Schmid, A. Straumann, J. Reichenbach, G.J. Gleich, H.-U. Simon: Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat. Med. 14 (2008), 949-953.
A. Straumann, S. Conus, L. Degen, S. Felder, M. Kummer, H. Engel, C. Bussmann, C. Beglinger, A. Schoepfer, H.-U. Simon: Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis. Gastroenterology 139 (2010), 1526-1537.
D. Simon, S. Hoesli, N. Roth, S. Staedler, S. Yousefi, H.-U. Simon: Eosinophil extracellular DNA traps in skin diseases. J. Allergy Clin. Immunol. 127 (2011), 194-199.