Daily Program
8:30 am – 3:30 pm |
Hypereosinophilic Syndrome Pre-Meeting Clinical WorkshopNovel Tools for Translational Research in Rare Eosinophil Associated Diseases |
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The Pre-Meeting Workshop is not included in the regular registration rate and can be added for an additional fee during the registration process. Click here to view the full Workshop program. |
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4:00 pm – 6:00 pm |
Eosinophils 101 |
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Moderators: Judah Denburg, Canada and Nicola Diny, Germany |
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4:00 pm – 4:21 pm |
Eosinophil Essentials: Identification and Assessment of Activity |
Paige Lacy, Canada |
4:22 pm – 4:43 pm |
How do Eosinophils Release their Secretory Products? |
Rossana Melo, Brazil |
4:44 pm – 5:05 pm |
Understanding Eosinophils in Health and Disease from Mouse Models to Human |
Elizabeth Jacobsen, United States |
5:06 pm – 5:27 pm |
How Eosinophils have Shaped the Therapy of T2 Diseases – History and Clinical Perspective |
Paul O'Byrne, Canada |
5:28 pm – 5:38 pm |
Living with EoE: A Patient’s Perspective on the Eosinophilic Journey |
Edward Gerstner, United States |
5:39 pm – 6:00 pm |
Panel Discussion |
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6:30 pm – 7:30 pm |
Opening Session |
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6:30 pm – 7:00 pm |
The History of the International Eosinophil Society and My Personal Journey |
Marc Rothenberg, United States |
7:00 pm – 7:30 pm |
Eosinophils in Asthma: A 100-year Journey. A Clinical Appraisal |
Jean Bousquet, France |
8:00 pm – 10:00 pm |
Welcome Reception |
8:30 am – 10:30 am |
Session 1: Eosinophils and the Epithelium |
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Moderators: Isabelle Arnold, Switzerland and Pedro Gazzinelli Guimaraes, United States | ||
8:30 am – 8:50 am |
State-of-the-Art: Signaling Pathways that Regulate Eosinophilic Responses in the Mucosa |
Simon Hogan, United States |
8:51 am – 9:11 am |
Cutting-Edge: Homeostatic Roles of Intestinal Eosinophils |
Nicola L. Harris, New Zealand |
9:12 am – 9:32 am |
Cutting-Edge: Localized Immune Circuits to Regulate Eosinophils in the Skin Epithelium Barrier |
Sang Hun Lee, United States |
9:33 am – 9:48 am |
Oral Abstract: The Role of Omeprazole in the Esophageal Epithelium in Eosinophilic Esophagitis |
Sierra Beach, United States |
9:49 am – 10:04 am |
Oral Abstract: Multi-Omics Analysis Identifies IL-4/13-Induced LTD4-Producing IL1RL1high Eosinophils and Their IL-33-Driven Activation Mechanism |
Jun Miyata, Japan |
10:05 am – 10:20 am |
Oral Abstract: Lung Eosinophils have Increased Activity and Adherence in Patients with Chronic Obstructive Pulmonary Disease |
Steven P. Cass, United Kingdom |
10:21 am – 10:26 am |
Abstract Slam: The Involvement of Neutrophils and Cannabinoid-related Receptor GPR55 in Eosinophilic Esophagitis |
Eva Gruden, Austria |
10:27 am – 10:32 am |
Abstract Slam: IL-5 Promotes Tissue Eosinophil Persistence Through Developmental Effects but is Not Essential for Lung Recruitment and Activation |
Kirena Mollers, Belgium |
10:30 am – 11:15 am |
Coffee Break & Poster Viewing |
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11:15 am – 12:00 pm |
Paul Ehrlich Award LectureModerator: Bruce S. Bochner, United States Evolving Paradigms in Eosinophil Biology and Function – A Career's Journey: “There and Back Again” |
Steven Ackerman, United States |
12:15 am – 1:45 pm |
Lunch with a Mentor Sessions |
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Designed for Early Career Attendees, these sessions offer a unique opportunity to connect with experienced mentors over lunch. Complimentary lunch boxes will be provided. |
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Non-Academic Career Paths – Industry, Government, Editorial |
Robert Brierley, United Kingdom Andrew Menzies-Gow, United Kingdom Calman Prussin, United States |
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Academic Career Paths – Clinical/Translational |
Praveen Akuthota, United States Jean-Emmanuel Kahn, France Princess Ogbogu, United States |
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Academic Career Paths - Basic |
Allison Fryer, United States Pedro Gazzinelli Guimaraes, United States David Voehringer, Germany |
2:00 pm – 3:30 pm |
Session 2: Genetic Determinants in Eosinophilic Disease |
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Moderators: Amy Klion, United States and Nives Zimmermann, United States | ||
2:00 pm – 2:05 pm |
Moderator Introduction |
Nives Zimmermann, United States |
2:06 pm – 2:26 pm |
State-of-the-Art: Relationship between Genetic Variants that Regulate Blood Eosinophilia and Allergic Disease Risk |
Leah Kottyan, United States |
2:27 pm – 2:47 pm |
Cutting-Edge: LNK (SH2B3) Deficiency and Eosinophilia and Arterial Thrombosis |
Nan Wang, United States |
2:48 pm – 3:03 pm |
Oral Abstract: Involvement of the JAK/STAT Pathway in Tyrosine Kinase Fusion-Free Patients with Hypereosinophilic Syndrome |
Matthieu G. Groh, France |
3:04 pm – 3:19 pm |
Oral Abstract: Molecular Profiling in Eosinophilic Gastritis Reveals Distinct Molecular Signatures: Post Hoc Analysis of the Phase 2 DEGAS Randomized Controlled Trial |
Tetsuo Shoda, United States |
3:20 pm – 3:25 pm |
Abstract Slam: Multiomic Immune Profiling Reveals Key Mechanisms Accounting for TCR/CD3 Loss in CD3-CD4+ T-cell Associated Lymphoid-Variant Hypereosinophilic Syndrome |
Julien Catherine, Belgium |
3:26 pm – 3:31 pm |
Abstract Slam: A Study on the Genetic Determinants of Eosinophilic Asthma in India |
Asmi Dubey, India |
4:00 pm – 5:30 pm |
Session 3: New Roles of Eosinophils as Effector Cells |
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Moderators: Stephane Esnault, France and Amali Samarasinghe, United States | ||
4:00 pm – 4:20 pm |
State-of-the-Art: Kinetics of the Eosinophil Compartment in Bone Marrow and Blood |
Leo Koenderman, Netherlands |
4:21 pm – 4:41 pm |
Cutting-Edge: Eosinophils Limit the Spread of Metastatic Pancreatic Cancer |
Stephanie K. Dougan, United States |
4:42 pm – 4:57 pm |
Oral Abstract: Eosinophil Subset Dynamics and Transcriptional Signatures in Colorectal Cancer Progression |
Glenn De Lange, Switzerland |
4:58 pm – 5:13 pm |
Oral Abstract: Physiological Level of Eosinophils is Essential for the Homeostasis and Regeneration of Hematopoietic Stem Cells |
Chao Zhang, China |
5:14 pm – 5:19 pm |
Abstract Slam: Eosinophil Antibacterial Functions in Defense Against Pneumonia from Synergistic Viral-Bacterial Infections |
Amali E. Samarasinghe, United States |
5:20 pm – 5:25 pm |
Abstract Slam: IFN-γ-NOD2-FCGR Axis and IFN-γ-IL-5 Interaction Enhance Eosinophil Extracellular Traps Formation in Patients with Allergic Bronchopulmonary Aspergillosis/Mycosis |
Hisashi Sasaki, Japan |
5:26 pm – 5:31 pm |
Abstract Slam: Spontaneous Coronary Artery Dissection Is Associated with Eosinophil Recruitment and Activation |
Michelle A. Makiya, United States |
5:30 pm – 6:30 pm |
Poster Session 1 |
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Eosinophils and the Epithelium 1 |
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Cellular Sources of IL-13 in Acute and Chronic Models of Eosinophilic Esophagitis |
Alfred Doyle, United States |
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Eosinophil Phenotypic Shifts During Inflammatory and Resolving Phases of a Mouse Model of Eosinophilic Esophagitis |
Allison M. Dubner, United States |
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Human Eosinophils Participate in the Epithelial-Mesenchymal Transition of Primary Bronchial Epithelial Cells |
Aurélia Lebeau, France |
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Increased Alveolar Eosinophils in Chronic Obstructive Pulmonary Disease |
Andrew Higham, United Kingdom |
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Development of Peanut Allergy in Mice is Regulated by Allergen-induced Keratinocyte-derived Interleukin-33 and the Recruitment of Eosinophils to the Skin: Skin IL33 Blocks Induction of Tolerance to Peanut |
Joan M. Cook-Mills, United States |
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Clinical and Laboratory Characteristics of Adults with Refractory Chronic Urticaria at a 19-Year Retrospective Study in a Single Tertiary Center |
Kyung-min Ahn, Korea |
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Tezepelumab in Refractory Eosinophilic Granulomatosis with Polyangiitis: A Case Study on Multidimensional Clinical Response |
Marcelo Teocchi, Italy |
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Anti-CD3/CD28-activated Peripheral Blood Mononuclear Cells Disrupt the Function of the Esophageal Epithelial Barrier |
Mirelle Kleuskens, Netherlands |
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Eosinophils in Intestinal Immunity and Disease 1 |
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ILC2-derived IL-5 is a Dominant Maturation Factor for Eosinophils at Steady State and Allergic Eosinophilia |
Christoph SN Klose, Germany |
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Eosinophil ETosis in Gastric Tumor Microenvironement: An Ultrastructural Study on Three Cases |
Rosario Caruso, Italy |
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Eosinophilia as a Diagnostic and Prognostic Marker in Helminthic Infections: A Clinical and Statistical Analysis |
Monika Dubey, India |
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Dupilumab Normalizes Key Histopathologic Features of Eosinophilic Esophagitis: Post Hoc Analysis of the Phase 3 Liberty EoE Treet Study |
Amr Radwan, United States |
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Immunoglobulins Profiles in Gastric Fluids of Eosinophilic Gastritis |
Ashley L. Pyne, United States |
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Building Tools to Characterize Eosinophil Biology in Nonhuman Primates: Insights from Lentiviral Infection |
Cordelia Manickam, United States |
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A Systemic Wave of Neonatal Eosinophils Promotes Tissue Homeostasis and Commensalism |
Ignacio Gonzalez Perez, Switzerland |
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Identification of Promising Noninvasive Biomarkers of Pediatric Eosinophilic Esophagitis |
Martina Votto, Italy |
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Identification of Peripheral Blood Eosinophil Count and Prominent Gastric Endoscopic Features as Indicators of Active Eosinophilic Gastritis: Post Hoc Baseline Analysis of the Phase 2 DEGAS Randomized Controlled Trial |
Marc Rothenberg, United States |
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Dupilumab Improves Clinical and Histologic Features of Eosinophilic Esophagitis Prior to 12 weeks of Treatment |
Ryan Din, United States |
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Effects of Proton Pump Inhibitors on Remodeling and Fibrosis in Eosinophilic Esophagitis |
Tetsuo Shoda, United States |
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Mechanisms of Eosinophil Development, Heterogeneity and Plasticity 1 |
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Regulation of Eosinophil Heterogeneity - A Possible Role of Epithelial Derived Cytokines |
Madeleine K. Radinger, Sweden |
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Free Eosinophil Granules in COPD Sputum |
Augusta S. Beech, United Kingdom |
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Exploring Eosinophil Plasticity Across Tissues Using Spectral Flow Cytometry |
Clotilde Lacroix, Germany |
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Characterization of Eosinophil Subsets in Hypereosinophilia-Associated Heart Disease |
Immaculeta Osuji, United States |
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Is Maternal High-fat Diet Riling Up Offspring's Response to Allergen? |
Zhenying (Jane) Nie, United States |
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New Roles of Eosinophils as Effector Cells 1 |
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Do Eosinophils at the Brain Borders Mediate Brain Fog in Allergic Asthma? |
Anna Hammerich Thysen, Denmark |
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Associations Between Blood Eosinophil Surface Proteins and Clinical Traits in Severe Asthma and CRSwNP |
Emeline Delaunay, France |
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Case Report: Steroid Resistant Bullous Pemphigoid and Hyper-Eosinophilic Syndrome: New Therapeutic Approaches and Therapeutic Challenges |
Marco Zurlo, Italy |
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Clinical Picture, Outcomes and Predictors of Relapse in Eosinophilia-Associated Coronary Vasospasm: Data from a European Multicentric Study |
Matthieu G. Groh, France |
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Blood Eosinophil Counts, Airway Infections and Inhaled Antibiotic Treatment in Bronchiectasis |
Mingxin Shi, China |
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Hyper-Eosinophilia in Hospitalized Patients is Linked with Increased Thrombotic Events and Mortality |
Ronen Shavit, Israel |
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Complement-eosinophil Axis Contributes to Fibrin Deposition in Eosinophilic Chronic Rhinosinusitis |
Shohei Nishiyama, Japan |
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Cytokines and Growth Factors Expressed, Transduced, Captured or Supplied to Other Cell Types by Human Blood Eosinophils: A Transcriptomics Approach |
Stephane Esnault, France |
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5:30 pm – 6:30 pm |
Abstract Slam Poster Session 1 |
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The Involvement of Neutrophils and Cannabinoid-related Receptor GPR55 in Eosinophilic Esophagitis |
Eva Gruden, Austria |
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IL-5 Promotes Tissue Eosinophil Persistence Through Developmental Effects but Is Not Essential for Lung Recruitment and Activation |
Kirena Mollers, Belgium |
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Multiomic Immune Profiling Reveals Key Mechanisms Accounting For TCR/CD3 Loss In CD3-CD4+ T-cell Associated Lymphoid-Variant Hypereosinophilic Syndrome |
Julien Catherine, Belgium |
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A Study on the Genetic Determinants of Eosinophilic Asthma in India |
Asmi Dubey, India |
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Eosinophil Antibacterial Functions in Defense Against Pneumonia from Synergistic Viral-Bacterial Infections |
Amali E. Samarasinghe, United States |
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IFN-γ-NOD2-FCGR Axis and IFN-γ-IL-5 Interaction Enhance Eosinophil Extracellular Traps Formation in Patients with Allergic Bronchopulmonary Aspergillosis/Mycosis |
Hisashi Sasaki, Japan |
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Spontaneous Coronary Artery Dissection Is Associated with Eosinophil Recruitment and Activation |
Michelle A. Makiya, United States |
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6:30 pm – 7:30 pm |
Ask an Expert Poster Session 1 |
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Evaluation of T-cell Clonality by T-cell Constant ß Chain (TRBC)1 and TRBC2 Expression Flow Cytometry in Hypereosinophilic Syndrome |
Alejandra Sánchez Santos, Spain |
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Three-Dimensional Modeling of Nerve Architecture and Myeloid Cell Interactions in Eosinophilic Gastrointestinal Disease |
Greg Constantine, United States |
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Whole Mount Immunohistochemistry Allows for 3-D Visualization and Quantitative Spatial Analysis |
Becky J. Proskocil, United States |
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Real-Time, High-Throughput Microscopic Quantification of Human Eosinophil Extracellular Trap Release for Assessing the Pharmacology of Antagonists |
Maarten Van Der Linden, Netherlands |
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Enhanced Detection of Eosinophil Granules in Cardiac Tissue Using Direct Fast Scarlet Staining |
Shigeharu Ueki, Japan |
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Morphological And Functional Study of Eosinophils Using Atomic Force Microscopy |
Vladimir Spasovski, France |
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6:30 pm – 7:30 pm |
Poster Session 2 |
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Eosinophils and the Epithelium 2 |
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NLR Family Pyrin Domain Containing 1 (NLRP1) Regulates Esophageal TSLP Expression and has a Key Role in Experimental Eosinophilic Esophagitis |
Ariel Wagner, Israel |
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Fibroblast Activation by Primary Human Eosinophils Corresponds with Eosinophil Specialization State |
Julia Dunn, United States |
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Eosinophilic Inflammation, IL-13 Expression and Small Airway Remodelling in Chronic Obstructive Pulmonary Disease |
Andrew Higham, United Kingdom |
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Eosinophil Interaction at the Nasal Epithelium Modulates Cell Permeability in Eosinophilic Severe Asthma: Effect of Anti-IL5R Therapy |
Katie L. Raby, United Kingdom |
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Eosinophils, Novel Key Players in the Extrapulmonary Dissemination of Cryptococcus Neoformans |
Lander De Herdt, Belgium |
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Eosinophil Peroxidase Impairs Esophageal Epithelial Barrier Function |
Marie Bek, Netherlands |
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Clinical Characteristics and Outcomes of Eosinophilic Myocarditis: A Single-Center Retrospective Study |
Noeul Kang, Korea |
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From Hypereosinophilia to Hypereosinophilic Syndrome (HES): Real-world Application of a Two-tailed Approach for HES Diagnosis |
Stefania Nicola, Italy |
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In Vitro Modelling of Eosinophil-Driven Mucosal Inflammation Using IPSC-Derived Organoids |
Zuzana Tomasikova, Czech Republic |
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Eosinophils in Intestinal Immunity and Disease 2 |
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Gastrointestinal Tract Mucosal Eosinophils in Healthy Adults |
Amiko Uchida, United States |
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Dupilumab Improves Histopathlogic Disease Activity Over 52 Weeks in Children with Eosinophilic Esophagitis: Findings from the Phase 3 EoE Kids Study |
Amr Radwan, United States |
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Mitochondria within Human Eosinophils Respond to Inflammation with Cristae Reshaping and Interorganellar Contact Sites |
Kassia Malta, Brazil |
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Novel Proteomic Analysis of Stool Smear Samples to Identify Eosinophil-Associated Biomarkers in Non-IgE-mediated Gastrointestinal Food Allergies |
Kaori Inukai, Japan |
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Identification of a Neuroimmune Circuit that Regulates Allergen-Induced Esophageal Eosinophilic Inflammatory Responses |
Kendall Kellerman, United States |
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The Aryl Hydrocarbon Receptor (AHR) Repressor Limits Expression of Antimicrobial Genes but Not AHR-Dependent Genes in Intestinal Eosinophils |
Nicola Diny, Germany |
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Dupilumab Improves Histologic and Endoscopic Features of Eosinophilic Gastritis: Results from the Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 DEGAS Trial |
Marc Rothenberg, United States |
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A Mixture of Ivy Leaf Extract and Coptidis Rhizoma Reduces Severe Eosinophilic Asthma in a Mouse Model |
So Ri Kim, Korea |
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Artificial Intelligence Driven Discovery of Novel 1,3,5-Sulphonamide Conjugate (TS-06) Inhibits Th2 Inflammation and Cellular Infiltration in a Mouse Model of Eosinophilic Esophagitis |
Udaya Pratap Singh, India |
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Mechanisms of Eosinophil Development, Heterogeneity and Plasticity 2 |
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Mepolizumab 300 mg Reduces Peripheral Blood and Tissue CD62Llow iEos in EGPA Patients |
Andrea Matucci, Italy |
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The Impact of Sustained IL-5 Elevation on Eosinophil Development and Hematopoietic Progenitors |
Brittany D. Gomez, United States |
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Copper Driven Metabolic Adaptation Sustains Eosinophil Differentiation and Activation in Asthma |
Fan Shi, China |
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Age And Sex Shape the Human Eosinophil Transcriptome |
Svetlana Pahernik, Austria |
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New Roles of Eosinophils as Effector Cells 2 |
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Pro-Inflammatory Milieu Impairs the Osteoprotective Role of Eosinophils |
Pauline Porschitz, Germany |
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Pharmacologically Induced Eosinophilia as a Novel Therapeutic Strategy for Glioblastoma: In Vivo Effects of Eosinophils on Tumor Suppression |
Bruno M. Vieira, Brazil |
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Blood Eosinophils Subtypes and Small Airways Dysfunction in Severe Asthma |
Daniele Previtero, Italy |
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Comparative Transcriptomic Data Analysis of Blood Eosinophils in Severe Asthma and CRSwNP Reveals Potential Functional Differences |
Emeline Delaunay, France |
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Associations Between Absolute Blood Eosinophil Count and Subclinical Atherosclerotic Plaque in the Multi-Ethnic Study of Atherosclerosis (MESA) |
Mats W. Johansson, United States |
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Ophthalmic Vascular Manifestations in Eosinophil-Associated Diseases: A Comprehensive Analysis Of 57 Patients from The CEREO And EESG Networks and a Literature Review |
Matthieu G. Groh, France |
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Eosinophil-Driven Hyperdynamic Circulation in EGPA: Impact of Anti-IL-5 Therapy. A Retrospective-Prospective Study |
Palma Carlucci, Italy |
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During Heligmosomoides bakeri Infection, Intestinal Eosinophils Express Ly6G |
Shashini K. Perera, Canada |
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STAT3 is Required for the Anti-tumorigenic Effects of Eosinophils in Breast Cancer-driven Lung Metastasis |
Shraddha Sharma, Israel |
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8:00 pm – 10:00 pm |
Early Career Networking Event |
8:30 am – 10:45 am |
Session 4: Eosinophils in Intestinal Immunity and Disease – Joint Session with CEGIR |
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Moderators: Gregory Constantine, United States and Joanne Masterson, Ireland | ||
8:30 am – 8:40 am |
Introduction |
Marc Rothenberg, United States |
8:41 am – 9:26 am |
Eosinophilic Disease Translational Research Award Lecture: Tissue Remodeling - Who is Responsible and What Does it Mean? |
Seema Aceves, United States |
9:27 am – 9:47 am |
Cutting-Edge: Neuronal Regulation of Eosinophils in the Small Intestine |
Heping Xu, China |
9:48 am – 10:08 am |
Cutting-Edge: Cellular and Molecular Mechanisms of Eosinophilic Esophagitis: Lessons from Experimental Models |
Ariel Munitz, Israel |
10:09 am – 10:24 am |
Oral Abstract: Esophageal Eosinophil Counts and Histologic Scores Correlate with Expression of GPR15 and CD38 by Peripheral Blood Pathogenic Effector Th2 Cells in Eosinophilic Esophagitis |
Caitlin M. Burk, United States |
10:25 am – 10:40 am |
Oral Abstract: Key, yet Distinct Roles for IL-13Ra1 and IL-4Ra in Eosinophilic Gastritis |
Anish Dsilva, Israel |
10:41 am – 10:46 am |
Abstract Slam: Eosinophils Control Intestinal Commensalism to Sustain Homeostasis |
Daniel Crepaz, Switzerland |
11:00 am – 12:00 pm |
Poster Session 3 |
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Eosinophils and Immunomodulation 1 |
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Efficacy Of Two Years of Treatment with Anti-IL-5/R Therapy for Reduction in Use of Oral Glucocorticoids in Patients with Eosinophilic Granulomatosis with Polyangiitis |
Florence E. Roufosse, Belgium |
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PD-L1-Expressing Eosinophil-Mediated Regulation of Immunity and Pulmonary Inflammation |
Daniel Ivers, Ireland |
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Neutrophilic Versus Eosinophilic Inflammation in Eosinophilic Granulomatosis with Polyangioitis (EGPA) |
Amedeo Votto, Italy |
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Bidirectional Risk of Autoimmune Disease and Eosinophilic Esophagitis in Sweden |
Ashley L. Pyne, United States |
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Untangling The Net: Unravelling Signalling Mechanisms of Eosinophil Extracellular DNA Traps Against Filarial Parasites |
Celia Nieto-Pérez, Germany |
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Eosinophil Recruitment to the Lung in Airway-Challenged Mice Is Enhanced by Basophil-dependent Sensitization Via the Skin |
Daniel Radtke, Germany |
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Inhibition Of EETosis With an Anti-Citrullinated Histone Antibody: A Novel Therapeutic Approach for Eosinophilic Inflammatory Disorders |
Eline Zwiers, Netherlands |
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Pharmacodynamic Effects of Benralizumab on Eosinophil-related Biomarkers in COPD: A Biomarker Analysis of the GALATHEA Study |
Lena Börjesson Sjö, Sweden |
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Eosinophil Immunometabolic Changes During the Course of Litomosoides Sigmodontis Filarial Infection |
Indulekha Karunakaran, Germany |
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Real-World Comparison of Biologic Therapies in Severe Asthma |
Sameer K. Mathur, United States |
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Kimura Disease Treated with Dupilumab |
Joo-Hee Kim, Korea |
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Spatiotemporal and 3D Cellular Architecture of Evolving Schistosoma Granulomas Uncover an Ecological Niche of Eosinophils |
Kassia K. Malta, Brazil |
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Dupilumab Efficacy and Safety in Patients with Moderate-to-Severe COPD with Type 2 Inflammation: Pooled Analysis of BOREAS and NOTUS Trials |
Jeremy Charriot, France |
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Blood Eosinophil Gene Expression, Cytokine Response and Cytology Is Altered with Anti-IL-5 Mepolizumab |
Katie L. Raby, United Kingdom |
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Ultrastructural Views of Galectin-10-loaded Extracelluar Vesicles Secreted by Human Eosinophils |
Livia A. S. Carmo, Brazil |
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Severe Adverse Reaction to Targeted Therapy in a Patient with Idiopathic Hypereosinophilic Syndrome: Evidence for a Shift In T-cell Polarization |
Margaux Leclercq, Belgium |
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Efficacy of Low-Dose Mepolizumab in Refractory EGPA in Aspects of Systemic Steroid Use and Remission |
Mi-Ae Kim, Korea |
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Eosinophils Contribute to the Defense Against Mycobacteria Through Two Distinct Mechanisms |
Miriam Herbert, Germany |
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Plasma Calprotectin: A New Biomarker of Severe Asthma and Mepolizumab Treatment Response? |
Pierre-Alexandre Gagnon, Canada |
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Efficacy of Anti-IL4Ra Antibody in a Patient with Hypereosinophilic Syndrome Non-Responsive to Anti-IL5 and Anti-IL5R Treatment- a Case Report |
Piotr Lacwik, Poland |
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Patient Perspectives on Disease Burden and Management of Hypereosinophilic Syndrome in Europe and the US: Evidence from a Real-World Survey in Clinical Practice |
Priya Jain, United Kingdom |
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Seminal Plasma-Dependent Eosinophil Extracellular Traps Drive the Endometrial Inflammatory Response in Jennies Post-Artificial Insemination |
Sebastia Company, Spain |
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Eosinophilia is Associated with a More Severe Clinical Phenotype in Patients with Sickle Cell Disease |
Victor Baucher, Belgium |
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Impact of Early Transient Increase in Eosinophil Count on the Long-Term Efficacy of Dupilumab in Patients with Moderate-to-Severe Asthma: LIBERTY ASTHMA TRAVERSE |
Engi Ahmed, France |
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Eosinophils and Tissue Repair 1 |
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During Heligmosomoides Bakeri Infection, Intestinal Eosinophils Regulate Wound Healing in Male but Not Female Mice |
Shashini K. Perera, Canada |
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Esophageal Nerve Density is Decreased in an L2-IL5 Model of Esophageal Esophagitis (EoE) |
Becky J. Proskocil, United States |
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Genetic Determinants in Eosinophilic Disease |
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Influence Of Pharmacogenetics on Response to Proton Pump Inhibitors in Eosinophilic Esophagitis: Results from a Large Retrospective Cohort from Four Spanish Hospitals |
Leticia Rodríguez-Alcolado, Spain |
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Mast Cells and Basophils 1 |
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Intracellular Analysis of Human Basophil Metabolism and Signaling by Flow Cytometry for Deeper Immunophenotyping |
Harris R. Droghini, United States |
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11:00 am – 12:00 pm |
Abstract Slam Poster Session 2 |
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Eosinophils Control Intestinal Commensalism to Sustain Homeostasis |
Daniel Crepaz, Switzerland |
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Phenotypic and Functional Profiles of Blood and BAL Eosinophils in Severe Eosinophilic Asthma |
Jessica Gates, United Kingdom |
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A Preliminary Report on Human Eosinophil Single Cell Transcriptomic Heterogeneity in Asthma and Comparison to Other Disease States |
Nicholas T. Hogan, United States |
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Airway Inflammation Drives Resting to Inflammatory Transition of Lung Eosinophils |
James I. King, Switzerland |
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Multi-Modal Immune Profiling Uncovers a Role for Type 2 Immunity in a Subset of Idiopathic Hypereosinophilic Syndrome Patients |
Sina Karimi, Belgium |
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ATF3-Regulated Eosinophils Drive Adipose Tissue Angiogenesis Via VEGFA Expression |
Kate G. R. Quinlan, Australia |
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Short Chain Fatty Acids Inhibit Eosinophil-Derived IL-4 and IL-13 Inflammation via Apoptosis in an HDAC Dependent Manner |
Amiko Uchida, United States |
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Characterization Of the Pro-Resolving Eosinophil Subset in Human Arthritis and its Regulation by Anti-Rheumatic Treatment |
Nagham Al Arawe, Germany |
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Eosinophils But Not Mast Cells Exert Anti-Tumorigenic Activity, Without Being Predictive Markers of the Long-Term Response to Bacillus Calmette-Guérin (BCG) Therapy in Patients with Bladder Carcinoma |
Ilan Zaffran, Israel |
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12:00 pm – 1:00 pm |
Ask an Expert Poster Session 2 |
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Specification of Eosinophilopoiesis from HiPSC-Derived Hemogenic Endothelial Cells |
Elizabeth L. Castle, Canada |
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Adapting The SCENITH Technology to Study Tissue Eosinophil Metabolism |
Kalyani Kulkarni, Germany |
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Development of an AI Model for Automated Count and Evaluation of Eosinophil Activation Status in Sputum Samples |
Nanna Dyhre-Petersen, Denmark |
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Eosinophil and Neutrophil Proteolytic Activity Profiling as a Novel Endotyping Tool in Airways Disease |
Nicholas T. Hogan, United States |
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Innovative Autofluorescence-driven Isolation Technique Reveals Increased TRPV1 Expression on CD16+ Eosinophils |
Tobias Weihrauch, Germany |
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12:00 pm – 1:00 pm |
Poster Session 4 |
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Eosinophils and Immunomodulation 2 |
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Efficacy of Two Years of Treatment with Anti-IL-5/R Therapy for Achieving Glucocorticoid-Free Sustained Remission in Eosinophilic Granulomatosis with Polyangiitis |
David J. Jackson, United Kingdom |
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Model-Based Comparison of the Pharmacokinetic/Pharmacodynamic and Eosinophilic Response of Benralizumab Versus Depemokimab At 12 Weeks |
Andrew Menzies-Gow, United Kingdom |
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Blood Eosinophil Count as a Predictor of Fat Mass Gain: A Longitudinal Observation Study in Healthy Individuals |
Byung-Keun Kim, Korea |
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Dupilumab Decreases Severe Exacerbation Rates and Improves Lung Function in Children with Type 2 Asthma, Irrespective of Early Increase in Blood Eosinophil Counts |
Engi Ahmed, France |
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The Inhibitory Effect of Anti-TSLP Therapy on the Blood Eosinophil Count in Severe Asthma |
Faizan Haris, United Kingdom |
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Efficacy And Safety of Mepolizumab 300 Mg in Eosinophilic Granulomatosis with Polyangiitis: A Meta-analysis of 8 Retrospective Studies |
Federico Spataro, Italy |
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Respiratory Virus-Induced T2 Inflammation During EGPA Relapses in Patients Treated with Anti-IL5R Therapy |
Francesca Cefaloni, Italy |
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Chronic Eosinophilic Pneumonia Treated with Anti IL-5 Therapy: A Case Series |
Gioele Castelli, Italy |
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Charcot–Leyden Crystal Protein: Roles as an Acylprotein Thioesterase in Mediating Palmitoylation Dependent Cytokine Secretion by Eosinophils |
Haibin Wang, United States |
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Severe Asthma Drives Epigenetic Reprogramming of Eosinophil Progenitors |
Isika Ram, Switzerland |
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Investigating Symptomatic, Endoscopic, and Histologic Remission after Step-down Dosing of Dupilumab in Patients with Eosinophilic Esophagitis |
Jerry Fu, United States |
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Dupilumab Efficacy in Patients with Chronic Obstructive Pulmonary Disease (COPD) with Type 2 Inflammation across Baseline Eosinophil Counts |
Jeremy Charriot, France |
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Impact of Dupilumab on Type 2 Inflammatory Biomarkers in Patients with Chronic Obstructive Pulmonary Disease (COPD) |
Jeremy Charriot, France |
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Role of Eosinophil Mitochondrial Function in Severe Eosinophilic Asthma |
Katie L. Raby, United Kingdom |
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Molecular Circadian Clock of Eosinophils: A Potential Therapeutic Target for Asthma |
Julia Teppan, Austria |
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Role of TSLP in Experimental Mouse Models of Type 2 Inflammatory Diseases |
Kiyomi Komori, United States |
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Evaluation Of NKT Cells In IHES Syndrome: Preliminary Data |
Marco Zurlo, Italy |
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Anti-tumorigenic Effects of Eosinophils on Lung Cancer Progression |
Melanie Kienzl, Austria |
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Intrinsic PD-L1:CD80 Signaling in Eosinophils Suppress IFN-Gama-Induced Eosinophil Activation |
Ariel Munitz, Israel |
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Organ involvement in Hypereosinophilic Syndrome – Insights from a Large Cohort Study |
Piotr Lacwik, Poland |
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NATRON: Study Design and Patient Characteristics of a Phase 3 Study Evaluating Benralizumab in Patients with Hypereosinophilic Syndrome |
Princess U. Ogbogu, United States |
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STING-Mediated Synergistic Augmentation of Type 2 Cytokine Signaling: Role of JAK/TYK Expression Dynamics |
Quan M. Nhu, United States |
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Chronic Eosinophilic Pulmonary Conditions: Disease Overlap and Treatment Practice in a Tertiary Referral Single-Center Cohort |
Sina Karimi, Belgium |
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Role for Complement C5 in Eosinophilic Inflammation of Severe Asthma |
Zhenan Deng, China |
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Eosinophils and Tissue Repair 2 |
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Effects of Dupilumab on Tissue Eosinophils and Eosinophils Sub-phenotypes in CRSwNP |
Alessandra Vultaggio, Italy |
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Associations Between Blood Eosinophils and Lung Function Decline in Elderly Individuals with Asthma and Healthy Controls |
Kyoung-Hee Sohn, Korea |
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Eosinophil Extracellular Traps in Active EGPA: A Key Pathogenic Mechanism and Biomarker for Disease Activity |
Zhenan Deng, China |
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Mast Cells and Basophils 2 |
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Mast Cell Activation and Complement Dysregulation in Eosinophilic Esophagitis |
Simin Zhang, United States |
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1:00 pm – 3:00 pm |
Session 5: Mechanisms of Eosinophil Development, Heterogeneity and Plasticity |
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Moderators: Mats Johansson, United States and Kate G. R. Quinlan, Australia | ||
1:00 pm – 1:20 pm
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State-of-the-Art: Regulation of the Eosinophil Lineage in Eosinophil-associated Diseases in the Context of Precision Therapy |
Christophe Desmet, Belgium |
1:21 pm – 1:41 pm
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Cutting-Edge: Transcriptional and Epigenetic Regulation of Eosinophil Development, Maturation and Tissue Specificity: Promoters, Enhancers and Beyond |
Jennifer Felton, United States |
1:42 pm – 2:02 pm
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Cutting-Edge: Transcriptional Regulation of Eosinophilopoiesis in Zebrafish |
Yiyue Zhang, China |
2:03 pm – 2:18 pm |
Oral Abstract: Tissue Specific Microenvironment Drives Eosinophil Metabolic Adaptation |
Svetoslav Chakarov, China |
2:19 pm – 2:34 pm |
Oral Abstract: Novel Role Of the Ikaros Transcription Factor in Eosinophil Development and Homeostasis |
Hilde Schjerven, United States |
2:35 pm – 2:40 pm |
Abstract Slam: Phenotypic and Functional Profiles of Blood and BAL Eosinophils in Severe Eosinophilic Asthma |
Jessica Gates, United Kingdom |
2:41 pm – 2:46 pm |
Abstract Slam: A Preliminary Report on Human Eosinophil Single Cell Transcriptomic Heterogeneity in Asthma and Comparison to Other Disease States |
Nicholas T. Hogan, United States |
2:46 pm – 2:51 pm |
Abstract Slam: Airway Inflammation Drives Resting to Inflammatory Transition of Lung Eosinophils |
James I. King, Switzerland |
3:15 pm – 4:00 pm |
Lifetime Achievement Award LectureModerator: Allison Fryer, United States Eosinophil Biology and Eosinophilic Disease |
Hans-Uwe Simon, Switzerland |
4:00 pm – 4:30 pm |
IES Business MeetingIES Members Only |
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5:00 pm – 9:30 pm |
Optional Tour |
8:30 am – 10:30 am |
Session 6: Eosinophils and Immunomodulation |
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Moderators: Julien Catherine, Belgium and Lisa Spencer, United States | ||
8:30 am – 8:50 am |
State-of-the-Art: Eosinophils Shape the Immune Landscape to Promote Homeostasis |
Isabelle Arnold, Switzerland |
8:51 am – 9:11 am
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Cutting-Edge: Stromal Cell and B cell Dialogue Potentiates IL-33-Enriched Lymphoid Niches to Support Eosinophil Recruitment and Function During Type 2 Immunity |
Lalit Kumar Dubey, Switzerland |
9:12 am – 9:32 am |
Cutting-Edge: Bacterial Skin Infection Reprograms Eosinophils with Consequences for Allergic Lung Inflammation |
Philipp Starkl, Austria |
9:33 am – 9:48 am |
Oral Abstract: IL-5 CAR-T Cell Therapy Mediates Pathogenic Eosinophil Depletion and Achieves Effective Remission in Refractory Eosinophilic Disorders |
Youqian Wu, China |
9:49 am – 10:04 am |
Oral Abstract: Food Allergen Challenge Elicits Gut-Derived, Lung-Migratory iILC2s Upstream of Eosinophil Recruitment into Remote Lungs |
Kriti Gupta, United States |
10:05 am – 10:20 am |
Oral Abstract: Eosinophil Migration in Breast Cancer Driven Lung Metastasis is Mediated by Annexin A1-FPR1 Interaction |
Shireen Barakey, Israel |
10:21 am – 10:26 am |
Abstract Slam: Multi-Modal Immune Profiling Uncovers a Role for Type 2 Immunity in a Subset of Idiopathic Hypereosinophilic Syndrome Patients |
Sina Karimi, Belgium |
10:30 am – 11:15 am |
Coffee Break & Poster Viewing |
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11:15 am – 12:45 pm |
Session 7: Eosinophils and Tissue Repair |
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Moderators: Seema Aceves, United States and Amiko Uchida, United States | ||
11:15 am – 11:35 am |
State-of-the-Art: Role of Eosinophils in Acute Liver Injury and Repair |
Cynthia Ju, United States |
11:36 am – 11:56 am |
Cutting-Edge: Eosinophils Preserve Bone Homeostasis by Inhibiting Excessive Osteoclast Formation and Activity Via Eosinophil Peroxidase |
Aline Bozec, Germany |
11:57 am – 12:12 pm |
Oral Abstract: Resolution Of the Dysfunctional Epithelium in Eosinophilic Esophagitis is Mediated by a HIF-1a -CD73-Adenosine Signalling Axis |
Shauna K. Kellett, Ireland |
12:13 pm – 12:28 pm |
Oral Abstract: Eosinophil in Airway Epithelial Repair |
Alexandre Ecrement, France |
12:29 pm – 12:34 pm |
Abstract Slam: ATF3-Regulated Eosinophils Drive Adipose Tissue Angiogenesis Via VEGFA Expression |
Kate G. R. Quinlan, Australia |
12:35 pm – 12:40 pm |
Abstract Slam: Short Chain Fatty Acids Inhibit Eosinophil-Derived IL-4 and IL-13 Inflammation via Apoptosis in an HDAC Dependent Manner |
Amiko Uchida, United States |
12:41 pm – 12:46 pm |
Abstract Slam: Characterization of the Pro-Resolving Eosinophil Subset in Human Arthritis and its Regulation by Anti-Rheumatic Treatment |
Nagham Al Arawe, Germany |
1:00 pm - 2:00 pm |
Satellite Symposium |
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Interconnectivity of Type 2 Inflammation Across Select Diseases This non-CME event, sponsored by Regeneron, is open to the first 50 participants and includes lunch. |
William W. Busse, United States |
3:00 pm – 4:30 pm |
Session 8: Mast Cells and Basophils – Joint Session with EMBRN |
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Moderators: Francesca Levi-Schaffer, Israel and Daniel Radtke, Germany | ||
3:00 pm – 3:10 pm |
Introduction |
Francesca Levi-Schaffer, Israel |
3:11 pm – 3:31 pm
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Cutting-Edge: Inflammasome Involvement in Anaphylactic Mast Cell Degranulation |
Soman Abraham, United States |
3:32 pm – 3:52 pm
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Cutting Edge: Basophils and Allergic Skin Inflammation |
Raif Geha, United States
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3:53 pm – 4:08 pm |
Oral Abstract: Neuroimmune Image Mapping of Eosinophilic Esophagitis in Mice and Humans |
Edward C. Gerstner, United States |
4:09 pm – 4:24 pm |
Oral Abstract: Targeting of the IL-5 Pathway in Severe Asthma Reduces Mast Cell Progenitors |
Jenny Hallgren Martinsson, Sweden |
4:25 pm – 4:30 pm |
Abstract Slam: Eosinophils But Not Mast Cells Exert Anti-Tumorigenic Activity, Without Being Predictive Markers of the Long-Term Response to Bacillus Calmette-Guérin (BCG) Therapy in Patients with Bladder Carcinoma |
Ilan Zaffran, Israel |
4:45 pm – 5:30 pm |
Gerald J. Gleich Award LectureModerator: Florence Roufosse, Belgium Single-cell Proteomics and Transcriptomics Capture Eosinophil Development and Identify the Role of IL-5 in their Lineage Transit Amplification |
Joseph Jorssen, Belgium Glenn Van Hulst, Netherlands |
7:00 pm – 10:00 pm |
Awards Dinner |
8:30 am – 10:00 am |
Roundtable Discussions |
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8:30 am – 9:15 am |
Why are Human Eosinophil Knock-Outs so Healthy Given the Many Roles Played by Eosinophils in Murine Health? |
Moderators: |
9:15 am – 10:00 am |
Biomarkers: From Bench to Bedside (Local/Peripheral, Quantity vs. Quality, Normal Eosinophil Counts) |
Moderators: |
10:00 am – 10:30 am |
Coffee Break |
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10:30 am – 11:30 am |
Technology and Techniques Session |
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Moderators: Shigeharu Ueki, Japan and Simin Zhang, United States | ||
10:30 am – 10:50 am |
Single-cell Analysis of Eosinophils |
Kristina Handler, Switzerland |
10:50 am – 11:10 am |
Updated Methods for Flow Cytometry, Including Mass Cytometry (CyTOF) |
Gabriella Wilson, United States |
11:10 am – 11:30 am |
Quantitative Analysis of Eosinophil Location in Tissue Using 3D Imaging |
Alexandra Pincus, United States |
11:30 am – 12:00 pm |
Lunch BreakLunch Boxes Provided |
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12:00 pm – 2:00 pm |
Pro/Con Debates |
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12:00 pm – 1:00 pm |
Biologics Targeting T2 Responses are Better than those Targeting Eosinophils for the Treatment of Eosinophilic Asthma Moderator: David Jackson, United Kingdom |
Pro: Michael Wechsler, United States Con: Parameswaran Nair, Canada |
1:00 pm – 2:00 pm |
What is the Key Factor in Determining Eosinophil Heterogeneity? Moderator: Elizabeth Jacobsen, United States |
Environment: Lisa Spencer, United States Pre-Determined: Sergejs Berdnikovs, United States |
2:00 pm – 2:15 pm |
Closing RemarksAllison Fryer, United States |