8:30 am – 10:30 am

Session 1: Eosinophils and the Epithelium

8:30 am – 8:50 am

State-of-the-Art: The Eosinophil-SFRP1+ Epithelial Cell Signaling Axis: A Central Driver of Proliferation and Treatment Resistance in Eosinophilic Esophagitis

Simon Hogan, United States 

8:51 am – 9:11 am 

Cutting-Edge: Homeostatic Roles of Intestinal Eosinophils 

Nicola L. Harris, New Zealand  

9:12 am – 9:32 am 

Cutting-Edge: Localized Immune Circuits to Regulate Eosinophils in the Skin Epithelium Barrier 

Sang Hun Lee, United States  

9:33 am – 9:48 am 

Oral Abstract: The Role of Omeprazole in the Esophageal Epithelium in Eosinophilic Esophagitis

Sierra Beach, United States 

9:49 am – 10:04 am 

Oral Abstract: Multi-Omics Analysis Identifies IL-4/13-Induced LTD4-Producing IL1RL1high Eosinophils and Their IL-33-Driven Activation Mechanism

Jun Miyata, Japan 

10:05 am – 10:20 am 

Oral Abstract: Lung Eosinophils have Increased Activity and Adherence in Patients with Chronic Obstructive Pulmonary Disease

Steven P. Cass, United Kingdom 

10:21 am – 10:26 am 

Abstract Slam: The Involvement of Neutrophils and Cannabinoid-related Receptor GPR55 in Eosinophilic Esophagitis

Eva Gruden, Austria 

10:27 am – 10:32 am 

Abstract Slam: IL-5 Promotes Tissue Eosinophil Persistence Through Developmental Effects but is Not Essential for Lung Recruitment and Activation

Kirena Mollers, Belgium 

10:30 am – 11:15 am

Coffee Break & Poster Viewing

11:15 am – 12:00 pm

Paul Ehrlich Award Lecture

Moderator: Bruce S. Bochner, United States

Evolving Paradigms in Eosinophil Biology and Function – A Career's Journey: “There and Back Again” 

Steven Ackerman, United States  

Designed for Early Career Attendees, these sessions offer a unique opportunity to connect with experienced mentors over lunch. Complimentary lunch boxes will be provided.

Non-Academic Career Paths – Industry, Government, Editorial     

Robert Brierley, United Kingdom

Andrew Menzies-Gow, United Kingdom

Calman Prussin, United States

Academic Career Paths – Clinical/Translational 

Praveen Akuthota, United States

Jean-Emmanuel Kahn, France

Princess Ogbogu, United States

Academic Career Paths - Basic 

Allison Fryer, United States

Pedro Gazzinelli Guimaraes, United States

David Voehringer, Germany

2:00 pm – 3:30 pm

Session 2: Genetic Determinants in Eosinophilic Disease

2:00 pm – 2:05 pm 

Moderator Introduction

Nives Zimmermann, United States

2:06 pm – 2:26 pm 

State-of-the-Art: Relationship between Genetic Variants that Regulate Blood Eosinophilia and Allergic Disease Risk

Leah Kottyan, United States 

2:27 pm – 2:47 pm 

Cutting-Edge: LNK (SH2B3) Deficiency and Eosinophilia and Arterial Thrombosis 

Nan Wang, United States  

2:48 pm – 3:03 pm

Oral Abstract: Involvement of the JAK/STAT Pathway in Tyrosine Kinase Fusion-Free Patients with Hypereosinophilic Syndrome

Matthieu G. Groh, France 

3:04 pm – 3:19 pm

Oral Abstract: Molecular Profiling in Eosinophilic Gastritis Reveals Distinct Molecular Signatures: Post Hoc Analysis of the Phase 2 DEGAS Randomized Controlled Trial

Tetsuo Shoda, United States 

3:20 pm – 3:25 pm

Abstract Slam: Multiomic Immune Profiling Reveals Key Mechanisms Accounting for TCR/CD3 Loss in CD3-CD4+ T-cell  Associated Lymphoid-Variant Hypereosinophilic Syndrome

Julien Catherine, Belgium 

3:26 pm – 3:31 pm

Abstract Slam: A Study on the Genetic Determinants of Eosinophilic Asthma in India

Asmi Dubey, India 

4:00 pm – 5:30 pm

Session 3: New Roles of Eosinophils as Effector Cells

4:00 pm – 4:20 pm 

State-of-the-Art: Kinetics of the Eosinophil Compartment in Bone Marrow and Blood

Leo Koenderman, Netherlands   

4:21 pm – 4:41 pm 

Cutting-Edge: Eosinophils Limit the Spread of Metastatic Pancreatic Cancer 

Stephanie K. Dougan, United States

4:42 pm – 4:57 pm

Oral Abstract: Eosinophil Subset Dynamics and Transcriptional Signatures in Colorectal Cancer Progression

Glenn De Lange, Switzerland 

4:58 pm – 5:13 pm

Oral Abstract: Physiological Level of Eosinophils is Essential for the Homeostasis and Regeneration of Hematopoietic Stem Cells

Chao Zhang, China 

5:14 pm – 5:19 pm

Abstract Slam: Eosinophil Antibacterial Functions in Defense Against Pneumonia from Synergistic Viral-Bacterial Infections

Amali E. Samarasinghe, United States 

5:20 pm – 5:25 pm

Abstract Slam: IFN-γ-NOD2-FCGR Axis and IFN-γ-IL-5 Interaction Enhance Eosinophil Extracellular Traps Formation in Patients with Allergic Bronchopulmonary Aspergillosis/Mycosis

Hisashi Sasaki, Japan 

5:26 pm – 5:31 pm

Abstract Slam: Spontaneous Coronary Artery Dissection Is Associated with Eosinophil Recruitment and Activation 

Michelle A. Makiya, United States  

5:30 pm – 6:30 pm

Poster Session 1

Eosinophils and the Epithelium 1 

Cellular Sources of IL-13 in Acute and Chronic Models of Eosinophilic Esophagitis 

Alfred Doyle, United States 

Eosinophil Phenotypic Shifts During Inflammatory and Resolving Phases of a Mouse Model of Eosinophilic Esophagitis 

Allison M. Dubner, United States 

Human Eosinophils Participate in the Epithelial-Mesenchymal Transition of Primary Bronchial Epithelial Cells 

Aurélia Lebeau, France 

Increased Alveolar Eosinophils in Chronic Obstructive Pulmonary Disease 

Andrew Higham, United Kingdom 

Development of Peanut Allergy in Mice is Regulated by Allergen-induced Keratinocyte-derived Interleukin-33 and the Recruitment of Eosinophils to the Skin: Skin IL33 Blocks Induction of Tolerance to Peanut 

Joan M. Cook-Mills, United States 

Clinical and Laboratory Characteristics of Adults with Refractory Chronic Urticaria at a 19-Year Retrospective Study in a Single Tertiary Center 

Kyung-min Ahn, Korea 

Tezepelumab in Refractory Eosinophilic Granulomatosis with Polyangiitis: A Case Study on Multidimensional Clinical Response 

Marcelo Teocchi, Italy 

Anti-CD3/CD28-activated Peripheral Blood Mononuclear Cells Disrupt the Function of the Esophageal Epithelial Barrier 

Mirelle Kleuskens, Netherlands 

Eosinophils in Intestinal Immunity and Disease 1 

ILC2-derived IL-5 is a Dominant Maturation Factor for Eosinophils at Steady State and Allergic Eosinophilia 

Christoph SN Klose, Germany 

Eosinophil ETosis in Gastric Tumor Microenvironement: An Ultrastructural Study on Three Cases 

Rosario Caruso, Italy 

Eosinophilia as a Diagnostic and Prognostic Marker in Helminthic Infections: A Clinical and Statistical Analysis 

Monika Dubey, India 

Dupilumab Normalizes Key Histopathologic Features of Eosinophilic Esophagitis: Post Hoc Analysis of the Phase 3 Liberty EoE Treet Study 

Amr Radwan, United States 

Immunoglobulins Profiles in Gastric Fluids of Eosinophilic Gastritis 

Ashley L. Pyne, United States 

A Systemic Wave of Neonatal Eosinophils Promotes Tissue Homeostasis and Commensalism 

Ignacio Gonzalez Perez, Switzerland 

Identification of Promising Noninvasive Biomarkers of Pediatric Eosinophilic Esophagitis 

Martina Votto, Italy 

Identification of Peripheral Blood Eosinophil Count and Prominent Gastric Endoscopic Features as Indicators of Active Eosinophilic Gastritis: Post Hoc Baseline Analysis of the Phase 2 DEGAS Randomized Controlled Trial 

Marc Rothenberg, United States 

Dupilumab Improves Clinical and Histologic Features of Eosinophilic Esophagitis Prior to 12 weeks of Treatment 

Ryan Din, United States 

Effects of Proton Pump Inhibitors on Remodeling and Fibrosis in Eosinophilic Esophagitis 

Tetsuo Shoda, United States 

Mechanisms of Eosinophil Development, Heterogeneity and Plasticity 1 

Regulation of Eosinophil Heterogeneity - A Possible Role of Epithelial Derived Cytokines 

Madeleine K. Radinger, Sweden 

Free Eosinophil Granules in COPD Sputum 

Augusta S. Beech, United Kingdom 

Exploring Eosinophil Plasticity Across Tissues Using Spectral Flow Cytometry 

Clotilde Lacroix, Germany 

Characterization of Eosinophil Subsets in Hypereosinophilia-Associated Heart Disease 

Immaculeta Osuji, United States 

Is Maternal High-fat Diet Riling Up Offspring's Response to Allergen? 

Zhenying (Jane) Nie, United States 

New Roles of Eosinophils as Effector Cells 1 

Do Eosinophils at the Brain Borders Mediate Brain Fog in Allergic Asthma? 

Anna Hammerich Thysen, Denmark 

Associations Between Blood Eosinophil Surface Proteins and Clinical Traits in Severe Asthma and CRSwNP 

Emeline Delaunay, France 

Case Report: Steroid Resistant Bullous Pemphigoid and Hyper-Eosinophilic Syndrome:  New Therapeutic Approaches and Therapeutic Challenges 

Marco Zurlo, Italy 

Clinical Picture, Outcomes and Predictors of Relapse in Eosinophilia-Associated Coronary Vasospasm: Data from a European Multicentric Study 

Matthieu G. Groh, France 

Blood Eosinophil Counts, Airway Infections and Inhaled Antibiotic Treatment in Bronchiectasis 

Mingxin Shi, China 

Hyper-Eosinophilia in Hospitalized Patients is Linked with Increased Thrombotic Events and Mortality 

Ronen Shavit, Israel 

Complement-eosinophil Axis Contributes to Fibrin Deposition in Eosinophilic Chronic Rhinosinusitis 

Shohei Nishiyama, Japan 

Cytokines and Growth Factors Expressed, Transduced, Captured or Supplied to Other Cell Types by Human Blood Eosinophils: A Transcriptomics Approach 

Stephane Esnault, France 

5:30 pm – 6:30 pm

Abstract Slam Poster Session 1

The Involvement of Neutrophils and Cannabinoid-related Receptor GPR55 in Eosinophilic Esophagitis 

Eva Gruden, Austria  

IL-5 Promotes Tissue Eosinophil Persistence Through Developmental Effects but Is Not Essential for Lung Recruitment and Activation 

Kirena Mollers, Belgium 

Multiomic Immune Profiling Reveals Key Mechanisms Accounting For TCR/CD3 Loss In CD3-CD4+ T-cell  Associated Lymphoid-Variant Hypereosinophilic Syndrome 

Julien Catherine, Belgium  

A Study on the Genetic Determinants of Eosinophilic Asthma in India 

Asmi Dubey, India  

Eosinophil Antibacterial Functions in Defense Against Pneumonia from Synergistic Viral-Bacterial Infections 

Amali E. Samarasinghe, United States  

IFN-γ-NOD2-FCGR Axis and IFN-γ-IL-5 Interaction Enhance Eosinophil Extracellular Traps Formation in Patients with Allergic Bronchopulmonary Aspergillosis/Mycosis  

Hisashi Sasaki, Japan  

Spontaneous Coronary Artery Dissection Is Associated with Eosinophil Recruitment and Activation 

Michelle A. Makiya, United States 

6:30 pm – 7:30 pm

Ask an Expert Poster Session 1

Evaluation of T-cell Clonality by T-cell Constant ß Chain (TRBC)1 and TRBC2 Expression Flow Cytometry in Hypereosinophilic Syndrome 

Alejandra Sánchez Santos, Spain 

Three-Dimensional Modeling of Nerve Architecture and Myeloid Cell Interactions in Eosinophilic Gastrointestinal Disease 

Greg Constantine, United States 

Whole Mount Immunohistochemistry Allows for 3-D Visualization and Quantitative Spatial Analysis 

Becky J. Proskocil, United States 

Real-Time, High-Throughput Microscopic Quantification of Human Eosinophil Extracellular Trap Release for Assessing the Pharmacology of Antagonists 

Maarten Van Der Linden, Netherlands 

Enhanced Detection of Eosinophil Granules in Cardiac Tissue Using Direct Fast Scarlet Staining 

Shigeharu Ueki, Japan 

Morphological And Functional Study of Eosinophils Using Atomic Force Microscopy 

Vladimir Spasovski, France 

6:30 pm – 7:30 pm

Poster Session 2

Eosinophils and the Epithelium 2 

NLR Family Pyrin Domain Containing 1 (NLRP1) Regulates Esophageal TSLP Expression and has a Key Role in Experimental Eosinophilic Esophagitis 

Ariel Wagner, Israel 

Fibroblast Activation by Primary Human Eosinophils Corresponds with Eosinophil Specialization State 

Julia Dunn, United States 

Eosinophilic Inflammation, IL-13 Expression and Small Airway Remodelling in Chronic Obstructive Pulmonary Disease 

Andrew Higham, United Kingdom 

Eosinophil Interaction at the Nasal Epithelium Modulates Cell Permeability in Eosinophilic Severe Asthma: Effect of Anti-IL5R Therapy 

 Katie L. Raby, United Kingdom 

Eosinophils, Novel Key Players in the Extrapulmonary Dissemination of Cryptococcus Neoformans 

Lander De Herdt, Belgium 

Eosinophil Peroxidase Impairs Esophageal Epithelial Barrier Function 

Marie Bek, Netherlands 

Clinical Characteristics and Outcomes of Eosinophilic Myocarditis: A Single-Center Retrospective Study 

 Noeul Kang, Korea 

From Hypereosinophilia to Hypereosinophilic Syndrome (HES): Real-world Application of a Two-tailed Approach for HES Diagnosis 

 Stefania Nicola, Italy 

In Vitro Modelling of Eosinophil-Driven Mucosal Inflammation Using IPSC-Derived Organoids 

Zuzana Tomasikova, Czech Republic 

Eosinophils in Intestinal Immunity and Disease 2 

Gastrointestinal Tract Mucosal Eosinophils in Healthy Adults 

Amiko Uchida, United States 

Dupilumab Improves Histopathlogic Disease Activity Over 52 Weeks in Children with Eosinophilic Esophagitis: Findings from the Phase 3 EoE Kids Study 

Amr Radwan, United States 

Mitochondria within Human Eosinophils Respond to Inflammation with Cristae Reshaping and Interorganellar Contact Sites 

Kassia Malta, Brazil 

Novel Proteomic Analysis of Stool Smear Samples to Identify Eosinophil-Associated Biomarkers in Non-IgE-mediated Gastrointestinal Food Allergies 

Kaori Inukai, Japan 

Identification of a Neuroimmune Circuit that Regulates Allergen-Induced Esophageal Eosinophilic Inflammatory Responses 

Kendall Kellerman, United States 

The Aryl Hydrocarbon Receptor (AHR) Repressor Limits Expression of Antimicrobial Genes but Not AHR-Dependent Genes in Intestinal Eosinophils 

Nicola Diny, Germany 

Dupilumab Improves Histologic and Endoscopic Features of Eosinophilic Gastritis: Results from the Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 DEGAS Trial 

Marc Rothenberg, United States 

A Mixture of Ivy Leaf Extract and Coptidis Rhizoma Reduces Severe Eosinophilic Asthma in a Mouse Model 

So Ri Kim, Korea 

Artificial Intelligence Driven Discovery of Novel 1,3,5-Sulphonamide Conjugate (TS-06) Inhibits Th2 Inflammation and Cellular Infiltration in a Mouse Model of Eosinophilic Esophagitis 

Udaya Pratap Singh, India 

Mechanisms of Eosinophil Development, Heterogeneity and Plasticity 2 

Mepolizumab 300 mg Reduces Peripheral Blood and Tissue CD62Llow iEos in EGPA Patients 

Andrea Matucci, Italy 

The Impact of Sustained IL-5 Elevation on Eosinophil Development and Hematopoietic Progenitors 

Brittany D. Gomez, United States 

Copper Driven Metabolic Adaptation Sustains Eosinophil Differentiation and Activation in Asthma 

Fan Shi, China 

Age And Sex Shape the Human Eosinophil Transcriptome 

Svetlana Pahernik, Austria 

New Roles of Eosinophils as Effector Cells 2 

Pro-Inflammatory Milieu Impairs the Osteoprotective Role of Eosinophils 

Pauline Porschitz, Germany 

Pharmacologically Induced Eosinophilia as a Novel Therapeutic Strategy for Glioblastoma: In Vivo Effects of Eosinophils on Tumor Suppression 

Bruno M. Vieira, Brazil 

Blood Eosinophils Subtypes and Small Airways Dysfunction in Severe Asthma 

Daniele Previtero, Italy 

Comparative Transcriptomic Data Analysis of Blood Eosinophils in Severe Asthma and CRSwNP Reveals Potential Functional Differences 

Emeline Delaunay, France 

Associations Between Absolute Blood Eosinophil Count and Subclinical Atherosclerotic Plaque in the Multi-Ethnic Study of Atherosclerosis (MESA) 

Mats W. Johansson, United States 

Ophthalmic Vascular Manifestations in Eosinophil-Associated Diseases: A Comprehensive Analysis Of 57 Patients from The CEREO And EESG Networks and a Literature Review 

Matthieu G. Groh, France 

Eosinophil-Driven Hyperdynamic Circulation in EGPA: Impact of Anti-IL-5 Therapy. A Retrospective-Prospective Study 

Palma Carlucci, Italy 

During Heligmosomoides bakeri Infection, Intestinal Eosinophils Express Ly6G 

Shashini K. Perera, Canada 

STAT3 is Required for the Anti-tumorigenic Effects of Eosinophils in Breast Cancer-driven Lung Metastasis 

Shraddha Sharma, Israel 

8:00 pm – 10:00 pm

Early Career Networking Event

8:30 am – 10:30 am

Session 4: Eosinophils in Intestinal Immunity and Disease – Joint Session with CEGIR

8:30 am – 8:40 am  

Introduction

Marc Rothenberg, United States  

8:41 am – 9:26 am

Eosinophilic Disease Translational Research Award Lecture: Tissue Remodeling - Who is Responsible and What Does it Mean? 

Seema Aceves, United States  

9:27 am – 9:47 am

Cutting-Edge: Neuronal Regulation of Eosinophils in the Small Intestine 

Heping Xu, China  

9:48 am – 10:08 am

Cutting-Edge: Cellular and Molecular Mechanisms of Eosinophilic Esophagitis: Lessons from Experimental Models

Ariel Munitz, Israel

10:09 am – 10:24 am 

10:25 am – 10:30 am

Abstract Slam: Eosinophils Control Intestinal Commensalism to Sustain Homeostasis 

Daniel Crepaz, Switzerland 

11:00 am – 12:00 pm

Poster Session 3

Eosinophils and Immunomodulation 1 

Efficacy Of Two Years of Treatment with Anti-IL-5/R Therapy for Reduction in Use of Oral Glucocorticoids in Patients with Eosinophilic Granulomatosis with Polyangiitis 

Florence E. Roufosse, Belgium 

PD-L1-Expressing Eosinophil-Mediated Regulation of Immunity and Pulmonary Inflammation 

Daniel Ivers, Ireland 

Neutrophilic Versus Eosinophilic Inflammation in Eosinophilic Granulomatosis with Polyangioitis (EGPA) 

Amedeo Votto, Italy 

Bidirectional Risk of Autoimmune Disease and Eosinophilic Esophagitis in Sweden 

Ashley L. Pyne, United States 

Untangling The Net: Unravelling Signalling Mechanisms of Eosinophil Extracellular DNA Traps Against Filarial Parasites 

Celia Nieto-Pérez, Germany 

Eosinophil Recruitment to the Lung in Airway-Challenged Mice Is Enhanced by Basophil-dependent Sensitization Via the Skin 

Daniel Radtke, Germany 

Inhibition Of EETosis With an Anti-Citrullinated Histone Antibody: A Novel Therapeutic Approach for Eosinophilic Inflammatory Disorders 

Eline Zwiers, Netherlands 

Pharmacodynamic Effects of Benralizumab on Eosinophil-related Biomarkers in COPD: A Biomarker Analysis of the GALATHEA Study 

Lena Börjesson Sjö, Sweden 

Eosinophil Immunometabolic Changes During the Course of Litomosoides Sigmodontis Filarial Infection 

Indulekha Karunakaran, Germany 

Real-World Comparison of Biologic Therapies in Severe Asthma 

Sameer K. Mathur, United States 

Kimura Disease Treated with Dupilumab 

Joo-Hee Kim, Korea 

Spatiotemporal and 3D Cellular Architecture of Evolving Schistosoma Granulomas Uncover an Ecological Niche of Eosinophils 

Kassia K. Malta, Brazil 

Dupilumab Efficacy and Safety in Patients with Moderate-to-Severe COPD with Type 2 Inflammation: Pooled Analysis of BOREAS and NOTUS Trials 

Jeremy Charriot, France 

Blood Eosinophil Gene Expression, Cytokine Response and Cytology Is Altered with Anti-IL-5 Mepolizumab 

Katie L. Raby, United Kingdom 

Ultrastructural Views of Galectin-10-loaded Extracelluar Vesicles Secreted by Human Eosinophils 

Livia A. S. Carmo, Brazil 

Severe Adverse Reaction to Targeted Therapy in a Patient with Idiopathic Hypereosinophilic Syndrome: Evidence for a Shift In T-cell Polarization 

Margaux Leclercq, Belgium 

Efficacy of Low-Dose Mepolizumab in Refractory EGPA in Aspects of Systemic Steroid Use and Remission 

Mi-Ae Kim, Korea 

Eosinophils Contribute to the Defense Against Mycobacteria Through Two Distinct Mechanisms 

Miriam Herbert, Germany 

Plasma Calprotectin: A New Biomarker of Severe Asthma and Mepolizumab Treatment Response? 

Pierre-Alexandre Gagnon, Canada 

Efficacy of Anti-IL4Ra Antibody in a Patient with Hypereosinophilic Syndrome Non-Responsive to Anti-IL5 and Anti-IL5R Treatment- a Case Report 

Piotr Lacwik, Poland 

Patient Perspectives on Disease Burden and Management of Hypereosinophilic Syndrome in Europe and the US: Evidence from a Real-World Survey in Clinical Practice 

Priya Jain, United Kingdom 

Seminal Plasma-Dependent Eosinophil Extracellular Traps Drive the Endometrial Inflammatory Response in Jennies Post-Artificial Insemination 

Sebastia Company, Spain 

Eosinophilia is Associated with a More Severe Clinical Phenotype in Patients with Sickle Cell Disease 

Victor Baucher, Belgium 

Impact of Early Transient Increase in Eosinophil Count on the Long-Term Efficacy of Dupilumab in Patients with Moderate-to-Severe Asthma: LIBERTY ASTHMA TRAVERSE 

Engi Ahmed, France 

Eosinophils and Tissue Repair 1 

During Heligmosomoides Bakeri Infection, Intestinal Eosinophils Regulate Wound Healing in Male but Not Female Mice 

Shashini K. Perera, Canada 

Esophageal Nerve Density is Decreased in an L2-IL5 Model of Esophageal Esophagitis (EoE)

Becky J. Proskocil, United States

Genetic Determinants in Eosinophilic Disease 

Influence Of Pharmacogenetics on Response to Proton Pump Inhibitors in Eosinophilic Esophagitis: Results from a Large Retrospective Cohort from Four Spanish Hospitals 

Leticia Rodríguez-Alcolado, Spain 

Mast Cells and Basophils 1 

Intracellular Analysis of Human Basophil Metabolism and Signaling by Flow Cytometry for Deeper Immunophenotyping 

Harris R. Droghini, United States 

11:00 am – 12:00 pm  

Abstract Slam Poster Session 2 

Eosinophils Control Intestinal Commensalism to Sustain Homeostasis 

Daniel Crepaz, Switzerland 

Phenotypic and Functional Profiles of Blood and BAL Eosinophils in Severe Eosinophilic Asthma 

Jessica Gates, United Kingdom 

A Preliminary Report on Human Eosinophil Single Cell Transcriptomic Heterogeneity in Asthma and Comparison to Other Disease States 

Nicholas T. Hogan, United States 

Airway Inflammation Drives Resting to Inflammatory Transition of Lung Eosinophils 

James I. King, Switzerland 

Multi-Modal Immune Profiling Uncovers a Role for Type 2 Immunity in a Subset of Idiopathic Hypereosinophilic Syndrome Patients 

Sina Karimi, Belgium 

ATF3-Regulated Eosinophils Drive Adipose Tissue Angiogenesis Via VEGFA Expression 

Kate G. R. Quinlan, Australia 

Short Chain Fatty Acids Inhibit Eosinophil-Derived IL-4 and IL-13 Inflammation via Apoptosis in an HDAC Dependent Manner 

Amiko Uchida, United States 

Characterization Of the Pro-Resolving Eosinophil Subset in Human Arthritis and its Regulation by Anti-Rheumatic Treatment 

Nagham Al Arawe, Germany 

Eosinophils But Not Mast Cells Exert Anti-Tumorigenic Activity, Without Being Predictive Markers of the Long-Term Response to Bacillus Calmette-Guérin (BCG) Therapy in Patients with Bladder Carcinoma   

Ilan Zaffran, Israel 

12:00 pm – 1:00 pm

Ask an Expert Poster Session 2 

Specification of Eosinophilopoiesis from HiPSC-Derived Hemogenic Endothelial Cells 

Elizabeth L. Castle, Canada 

Adapting The SCENITH Technology to Study Tissue Eosinophil Metabolism 

Kalyani Kulkarni, Germany 

Development of an AI Model for Automated Count and Evaluation of Eosinophil Activation Status in Sputum Samples 

Nanna Dyhre-Petersen, Denmark 

Eosinophil and Neutrophil Proteolytic Activity Profiling as a Novel Endotyping Tool in Airways Disease 

Nicholas T. Hogan, United States 

Innovative Autofluorescence-driven Isolation Technique Reveals Increased TRPV1 Expression on CD16+ Eosinophils 

Tobias Weihrauch, Germany 

12:00 pm – 1:00 pm

Poster Session 4

Eosinophils and Immunomodulation 2 

Efficacy of Two Years of Treatment with Anti-IL-5/R Therapy for Achieving Glucocorticoid-Free Sustained Remission in Eosinophilic Granulomatosis with Polyangiitis 

David J. Jackson, United Kingdom 

Model-Based Comparison of the Pharmacokinetic/Pharmacodynamic and Eosinophilic Response of Benralizumab Versus Depemokimab At 12 Weeks 

Andrew Menzies-Gow, United Kingdom 

Blood Eosinophil Count as a Predictor of Fat Mass Gain: A Longitudinal Observation Study in Healthy Individuals 

Byung-Keun Kim, Korea 

Dupilumab Decreases Severe Exacerbation Rates and Improves Lung Function in Children with Type 2 Asthma, Irrespective of Early Increase in Blood Eosinophil Counts 

Engi Ahmed, France 

The Inhibitory Effect of Anti-TSLP Therapy on the Blood Eosinophil Count in Severe Asthma 

Faizan Haris, United Kingdom 

Efficacy And Safety of Mepolizumab 300 Mg in Eosinophilic Granulomatosis with Polyangiitis: A Meta-analysis of 8 Retrospective Studies 

Federico Spataro, Italy 

Respiratory Virus-Induced T2 Inflammation During EGPA Relapses in Patients Treated with Anti-IL5R Therapy 

Francesca Cefaloni, Italy 

Chronic Eosinophilic Pneumonia Treated with Anti IL-5 Therapy: A Case Series 

Gioele Castelli, Italy 

Charcot–Leyden Crystal Protein: Roles as an Acylprotein Thioesterase in Mediating Palmitoylation Dependent Cytokine Secretion by Eosinophils 

Haibin Wang, United States 

Severe Asthma Drives Epigenetic Reprogramming of Eosinophil Progenitors 

Isika Ram, Switzerland 

Investigating Symptomatic, Endoscopic, and Histologic Remission after Step-down Dosing of Dupilumab in Patients with Eosinophilic Esophagitis 

Jerry Fu, United States 

Dupilumab Efficacy in Patients with Chronic Obstructive Pulmonary Disease (COPD) with Type 2 Inflammation across Baseline Eosinophil Counts 

Jeremy Charriot, France 

Impact of Dupilumab on Type 2 Inflammatory Biomarkers in Patients with Chronic Obstructive Pulmonary Disease (COPD) 

Jeremy Charriot, France 

Role of Eosinophil Mitochondrial Function in Severe Eosinophilic Asthma 

Katie L. Raby, United Kingdom 

Molecular Circadian Clock of Eosinophils: A Potential Therapeutic Target for Asthma 

Julia Teppan, Austria 

Role of TSLP in Experimental Mouse Models of Type 2 Inflammatory Diseases 

Kiyomi Komori, United States 

Evaluation Of NKT Cells In IHES Syndrome: Preliminary Data 

Marco Zurlo, Italy 

Anti-tumorigenic Effects of Eosinophils on Lung Cancer Progression 

Melanie Kienzl, Austria 

Intrinsic PD-L1:CD80 Signaling in Eosinophils Suppress IFN-Gama-Induced Eosinophil Activation 

Ariel Munitz, Israel 

Organ involvement in Hypereosinophilic Syndrome – Insights from a Large Cohort Study 

Piotr Lacwik, Poland 

NATRON: Study Design and Patient Characteristics of a Phase 3 Study Evaluating Benralizumab in Patients with Hypereosinophilic Syndrome 

Princess U. Ogbogu, United States 

STING-Mediated Synergistic Augmentation of Type 2 Cytokine Signaling: Role of JAK/TYK Expression Dynamics 

Quan M. Nhu, United States 

Chronic Eosinophilic Pulmonary Conditions: Disease Overlap and Treatment Practice in a Tertiary Referral Single-Center Cohort 

Sina Karimi, Belgium 

Role for Complement C5 in Eosinophilic Inflammation of Severe Asthma 

Zhenan Deng, China 

Phenotyping T Cells from Lymphocytic Variant Hypereosinophilic Syndrome Patients Identifies the Expansion of Multiple CD4+ T cell Lineages

Charles Anderson, United States

Eosinophils and Tissue Repair 2 

Effects of Dupilumab on Tissue Eosinophils and Eosinophils Sub-phenotypes in CRSwNP 

Alessandra Vultaggio, Italy 

Associations Between Blood Eosinophils and Lung Function Decline in Elderly Individuals with Asthma and Healthy Controls 

Kyoung-Hee Sohn, Korea 

Eosinophil Extracellular Traps in Active EGPA: A Key Pathogenic Mechanism and Biomarker for Disease Activity 

Zhenan Deng, China 

Mast Cells and Basophils 2 

Mast Cell Activation and Complement Dysregulation in Eosinophilic Esophagitis 

Simin Zhang, United States 

1:00 pm – 3:00 pm  

Session 5: Mechanisms of Eosinophil Development, Heterogeneity and Plasticity 

1:00 pm – 1:20 pm 

State-of-the-Art: Regulation of the Eosinophil Lineage in Eosinophil-associated Diseases in the Context of Precision Therapy

Christophe Desmet, Belgium

1:21 pm – 1:41 pm 

Cutting-Edge: Transcriptional and Epigenetic Regulation of Eosinophil Development, Maturation and Tissue Specificity: Promoters, Enhancers and Beyond 

Jennifer Felton, United States    

1:42 pm – 2:02 pm 

Cutting-Edge: Transcriptional Regulation of Eosinophilopoiesis in Zebrafish 

Yiyue Zhang, China  

2:03 pm – 2:18 pm

Oral Abstract: Tissue Specific Microenvironment Drives Eosinophil Metabolic Adaptation

Svetoslav Chakarov, China 

2:19 pm – 2:34 pm

Oral Abstract: Novel Role Of the Ikaros Transcription Factor in Eosinophil Development and Homeostasis

Hilde Schjerven, United States 

2:35 pm – 2:40 pm

Abstract Slam: Phenotypic and Functional Profiles of Blood and BAL Eosinophils in Severe Eosinophilic Asthma

Jessica Gates, United Kingdom 

2:41 pm – 2:46 pm

Abstract Slam: A Preliminary Report on Human Eosinophil Single Cell Transcriptomic Heterogeneity in Asthma and Comparison to Other Disease States

Nicholas T. Hogan, United States 

2:46 pm – 2:51 pm

Abstract Slam: Airway Inflammation Drives Resting to Inflammatory Transition of Lung Eosinophils

James I. King, Switzerland 

3:15 pm – 4:00 pm

Lifetime Achievement Award Lecture

Moderator: Allison Fryer, United States

Eosinophil Biology and Eosinophilic Disease

Dagmar Simon, Switzerland  

Hans-Uwe Simon, Switzerland  

4:00 pm – 4:30 pm

IES Business Meeting

IES Members Only

5:00 pm – 9:30 pm

Optional Tour

8:30 am – 10:30 am

Session 6: Eosinophils and Immunomodulation

8:30 am – 8:50 am 

State-of-the-Art: Eosinophils Shape the Immune Landscape to Promote Homeostasis 

Isabelle Arnold, Switzerland  

8:51 am – 9:11 am  

Cutting-Edge: Stromal Cell and B cell Dialogue Potentiates IL-33-Enriched Lymphoid Niches to Support Eosinophil Recruitment and Function During Type 2 Immunity 

Lalit Kumar Dubey, Switzerland

9:12 am – 9:32 am 

Cutting-Edge: Bacterial Skin Infection Reprograms Eosinophils with Consequences for Allergic Lung Inflammation

Philipp Starkl, Austria

9:33 am – 9:48 am

Oral Abstract: IL-5 CAR-T Cell Therapy Mediates Pathogenic Eosinophil Depletion and Achieves Effective Remission in Refractory Eosinophilic Disorders

Youqian Wu, China 

9:49 am – 10:04 am

Oral Abstract: Food Allergen Challenge Elicits Gut-Derived, Lung-Migratory iILC2s Upstream of Eosinophil Recruitment into Remote Lungs

Kriti Gupta, United States 

10:05 am – 10:20 am

Oral Abstract: Eosinophil Migration in Breast Cancer Driven Lung Metastasis is Mediated by Annexin A1-FPR1 Interaction

Shireen Barakey, Israel 

10:21 am – 10:26 am

Abstract Slam: Multi-Modal Immune Profiling Uncovers a Role for Type 2 Immunity in a Subset of Idiopathic Hypereosinophilic Syndrome Patients

Sina Karimi, Belgium 

10:30 am – 11:15 am

Coffee Break & Poster Viewing

11:15 am – 12:45 pm

Session 7: Eosinophils and Tissue Repair

11:15 am – 11:35 am

State-of-the-Art: Role of Eosinophils in Acute Liver Injury and Repair 

Cynthia Ju, United States  

11:36 am – 11:56 am

Cutting-Edge: Eosinophils Preserve Bone Homeostasis by Inhibiting Excessive Osteoclast Formation and Activity Via Eosinophil Peroxidase

Aline Bozec, Germany

11:57 am – 12:12 pm

Oral Abstract: Resolution Of the Dysfunctional Epithelium in Eosinophilic Esophagitis is Mediated by a HIF-1a  -CD73-Adenosine Signalling Axis  

Shauna K. Kellett, Ireland 

12:13 pm – 12:28 pm

Oral Abstract: Eosinophil in Airway Epithelial Repair

Alexandre Ecrement, France 

12:29 pm – 12:34 pm

Abstract Slam: ATF3-Regulated Eosinophils Drive Adipose Tissue Angiogenesis Via VEGFA Expression

Kate G. R. Quinlan, Australia 

12:35 pm – 12:40 pm

Abstract Slam: Short Chain Fatty Acids Inhibit Eosinophil-Derived IL-4 and IL-13 Inflammation via Apoptosis in an HDAC Dependent Manner

Amiko Uchida, United States 

12:41 pm – 12:46 pm

Abstract Slam: Characterization of the Pro-Resolving Eosinophil Subset in Human Arthritis and its Regulation by Anti-Rheumatic Treatment 

Nagham Al Arawe, Germany 

1:00 pm - 2:00 pm

Satellite Symposium

Interconnectivity of Type 2 Inflammation Across Select Diseases

This non-CME event, sponsored by Regeneron, is open to the first 50 participants and includes lunch.

William W. Busse, United States 

3:00 pm – 4:30 pm

Session 8: Mast Cells and Basophils – Joint Session with EMBRN

3:00 pm – 3:10 pm 

Introduction

Francesca Levi-Schaffer, Israel   

3:11 pm – 3:31 pm 

Cutting-Edge: Inflammasome Involvement in Anaphylactic Mast Cell Degranulation  

Soman Abraham, United States  

3:32 pm – 3:52 pm 

Cutting Edge: Basophils and Allergic Skin Inflammation  

Raif Geha, United States  

3:53 pm – 4:08 pm

Oral Abstract: Neuroimmune Image Mapping of Eosinophilic Esophagitis in Mice and Humans

Edward C. Gerstner, United States 

4:09 pm – 4:24 pm

Oral Abstract: Targeting of the IL-5 Pathway in Severe Asthma Reduces Mast Cell Progenitors

Jenny Hallgren Martinsson, Sweden 

4:25 pm – 4:30 pm

Abstract Slam: Eosinophils But Not Mast Cells Exert Anti-Tumorigenic Activity, Without Being Predictive Markers of the Long-Term Response to Bacillus Calmette-Guérin (BCG) Therapy in Patients with Bladder Carcinoma

Ilan Zaffran, Israel 

4:45 pm – 5:30 pm

Gerald J. Gleich Award Lecture

Moderator: Florence Roufosse, Belgium

Single-cell Proteomics and Transcriptomics Capture Eosinophil Development and Identify the Role of IL-5 in their Lineage Transit Amplification 

Joseph Jorssen, Belgium

 Glenn Van Hulst, Netherlands  

6:45 pm – 10:00 pm

Awards Dinner

8:30 am – 10:00 am

Roundtable Discussions

8:30 am – 9:15 am 

Why are Human Eosinophil Knock-Outs so Healthy Given the Many Roles Played by Eosinophils in Murine Health? 

Moderators:  
Matthew Drake, United States 
Manali Mukherjee, Canada  

9:15 am – 10:00 am

Biomarkers: From Bench to Bedside (Local/Peripheral, Quantity vs. Quality, Normal Eosinophil Counts) 

Moderators:  
Paneez Khoury, United States  
Fei Lei Kuang, United States  

10:00 am – 10:30 am

Coffee Break

10:30 am – 11:30 am

Technology and Techniques Session

10:30 am – 10:50 am 

Single-cell Analysis of Eosinophils 

Kristina Handler, Switzerland

10:50 am – 11:10 am 

Updated Methods for Flow Cytometry, Including Mass Cytometry (CyTOF)  

Gabriella Wilson, United States

11:10 am – 11:30 am 

Quantitative Analysis of Eosinophil Location in Tissue Using 3D Imaging 

Alexandra Pincus, United States  

11:30 am – 12:00 pm

Lunch Break

Lunch Boxes Provided

12:00 pm – 2:00 pm

Pro/Con Debates

12:00 pm – 1:00 pm

Biologics Targeting T2 Responses are Better than those Targeting Eosinophils for the Treatment of Eosinophilic Asthma  

Moderator: David Jackson, United Kingdom

Pro: Praveen Akuthota, United States

Con: Parameswaran Nair, Canada

1:00 pm – 2:00 pm 

What is the Key Factor in Determining Eosinophil Heterogeneity?

Moderator: Elizabeth Jacobsen, United States

Environment:  Lisa Spencer, United States

Pre-Determined: Sergejs Berdnikovs, United States  

2:00 pm – 2:15 pm

Closing Remarks

Allison Fryer, United States
Marc Rothenberg, United States