Cookie Notice

This site uses cookies. By continuing to browse this site, you are agreeing to our use of cookies. Review our cookies information for more details.


Scientific Program


The initial schedule for the 2019 IES Symposium is listed below.

IES Scientific Program                   

Tuesday 9 July

Welcome Reception (Portland Marriott Downtown Waterfront)

18:00 - 18:30 Welcome -
Bruce Bochner, USA & Allison Fryer, USA

18:30 - 19:00 History of Eosinophil Discovery or Why Did Eosinophils Capture My Attention - Jerry Gleich, USA

19:00 - 21:00 Welcome Reception


Wednesday 10 July

07:00 - 08:00 Breakfast with a Mentor Session: How to Navigate a Scientific Conference - Jackie Wirz, USA

Session 1: Eosinophils Across Species, What Does That Tell Us About Their Physiological Role, Evolution and Choice of Animal Models

08:15 - 08:45 On the Origin of Eosinophils by Means of Natural Selection: Preservation of a Favored Leukocyte in the Struggle for Life - Steve Ackerman, USA

08:45 - 09:15 Eosinophils and Disease Models from Mouse to Man: We are Stronger Together - Helene Rosenberg, USA

09:15 - 09:45 Eosinophil Identity in the Tissue Contexts of Development, Homeostasis, and Disease - Sergejs Berdnikovs, USA

Abstract Presentations

09:45 - 10:00 Real-Time in Vivo Imaging of Tissue Resident Eosinophils Under Homeostatic and Inflammatory Conditions - Kamala D. Patel, Canada


10:00 - 10:30 Morning Break


Session 2: Eosinophil Life Cycle, Hematopoiesis and Recruitment, Activation and Death

10:30 - 11:00 Hemopoietic Mechanisms in Eosinophilic Inflammation - Roma Sehmi, Canada

11:00 - 11:30 Eosinophils in Liver Death - Todd Davidson, USA

11:30 - 12:00 Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation - Shigeharu Ueki, Japan

12:00 - 12:30 Eosinophil Shape Change and Granule Secretion - Paige Lacy, Canada

12:30 - 13:00 IES Business Meeting


13:00 - 14:30 Lunch (on your own)


14:30 - 15:30 Gleich Award Winner Lecture -
Eosinophil Depletion Suppresses Radiation-Induced Small Intestinal Fibrosis
- Naoki Takemura, Japan

15:30 - 16:00 Eosinophil Extracellular DNA Traps in Skin Diseases - Dagmar Simon, Switzerland

Abstract Presentations

16:00 - 16:15 First Ultrastructural Demonstration of Galectin-10 in Resting and Activated Human Eosinophils - Rossana Melo, Brazil

16:15 - 16:30 SIGLEC-8 Signals Through an Unanticipated Set of Molecules to Induce Integrin Upregulation and Activation, ROS Production, and Cell Death in Eosinophils - Jeremy O'Sullivan, USA


17:00 - 19:00 Poster Session 1


Poster 1 - Eosinophil Infiltration Does Not Exacerbate Muscle Pathology in the MDX Mouse Model of Duchenne Muscular Dystrophy - Albert Sek

Poster 3 - In Vitro and In Vivo Inhibition of Eosinophil Activation by Lysophosphatidylcholine and Synthetic Alkyl-Lysophosphatidylcholine - Eva Knuplez

Poster 5 - Characterizing SIGLECF+GR1- and SIGLECF+GR1+ Mouse Bone Marrow-Derived Eosinophils (bmEos) Cultured Ex Vivo - Eric Mai

Poster 9 - Nasal Polyps as a Presenting Sign of Systemic Eosinophilic Diseases - Yossi Rosman

Poster 11 - Dexpramipexole Responsiveness is increased in Eosinophilic Patients - Calman Prussin

Poster 13 - Single Site, Five-Year Experience with Human Eosinophil Isolation by Density Gradient Centrifugation and Immunomagnetic Negative Separation - Yun Cao

Poster 15 - Genetic Variation in Surfactant Protein-A2 and the Effect on Eosinophil Resolution in Allergic Airways - Alane Blythe C. Dy

Poster 17 - Eosinophil Cytolysis on IGG Requires Microtubule Array Formation, and P-38 Phosphorylation Downstream of Reactive Oxygen Species Production - Stephane Esnault

Poster 19 - IL-9 and IL-13 Storage and Release from Eosinophils - Sarah Almas

Poster 21 - The Role of Eosinophils in Obesity-Related Asthma - Gina Calco

Poster 23 - Kinetic Studies of Galectin-10 Release From Eosinophils to Proliferating T Cells - Christine Lingblom

Poster 25 - Eosinophil Responses to IL-4, IL-33 and Bacteria are Differentially Regulated by Apoptotic Cells - Avishay Dolitzky

Poster 27 - Harnessing Hymenolepis Diminuta Extract to Active Anti-Tumorigenic Activities of Eosinophils in Colorectal Cancer - Inbal Hazot

Poster 29 - Granulocyte Kinetics in the Blood and Sputum of Patients with Eosinophilic and Neutrophilic Inflammation - Leo Koenderman

Poster 31 - IGG4-Related Disease and Hypereosinophilic Syndrome: Overlapping Phenotypes? - Matthieu Groh

Poster 33 - Allergic Bronchopulmonary Aspergillosis as a Complication of COPD: A New Entity? - Matthieu Groh

Poster 35 - Intrinsic Sex-Specific Differences in Fibrotic Gene Expression and Pathology Contribute To Male Disease Predisposition in Pediatric Eosinophilic Esophagitis - Loan Duong

Poster 37 - Urine Levels Of Eosinophil Granule Proteins; A Better Biomarker of Eosinophilic Disease Activity? - Michelle Makiya

Poster 39 - Fluid Shear Stress Induces Rapid Actin Rearrangement in Eosinophils - Kiho Son

Poster 41 - Kruppel-Like Factor 3 (KLF3) Regulates Adipose Tissue Beiging via Eosinophils - Emily Vohralik

Poster 43 - Association of Blood Eosinophil Phenotypes and Patient Self-Assessment Data with Response to Treatment in Eosinophilic Esophagitis - Sofie Albinsson

Poster 45 - Eosinophilic Gastrointestinal Disease Treatment Approaches are Associated with Frequency of Feelings of Isolation - Elizabeth Jensen

Poster 47 - Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared To Common Beta-Chain Cytokines IL-5 and GM-CSF - Praveen Akuthota

Poster 49 - Eosinophils Suppress TH1 Responses and Restrict Bacterially Induced Gastrointestinal Inflammation - Isabelle Arnold

Poster 51 - Clinical and Endoscopic Features of the Fibrostenotic Phenotype in Eosinophilic Esophogitis - Paul Fichtinger

Poster 53 - Molecular, Endoscopic, Histological and Circulating Biomarker-Based Diagnosis of Eosinophilic Gastritis: Cross Sectional Multi-Site Study - Tetsuo Shoda

Poster 55 - Eosinophils are Present in Human and Mouse ESCC Tumors and May Be Protective in Tumorigenesis - Yash Choksi

Poster 57 - Eosinophils Alter Steady-State Small Intestinal IL-1α and IL-1ß Levels but are not Required for the Maintenance of Secretory IGA nor for Control of an Enteric Bacterial Pathogen - Rachael Brown

Poster 59 - Transgenic Expression of a Novel Secreted Active Form of IL-33 Promotes Eosinophilia in a Mouse Model of Eosinophilic Esophagitis - Benjamin Wright

Poster 61 - Hypereosinophilia Associated with Clonal CD3-CD4+ T Cells:  Characterization and Outcome of a New Cohort of Patients - Sylvain Verbanck

Poster 63 - CD200R1 is Upregulated in the Esophageal Epithelium in Eosinophilic Esophagitis - Netali Ben Baruch-Morgenstern

Poster 65 - Eosinophil Subtype Specific Metabolic Activities - Elizabeth Jacobsen

Poster 67 - Eosinophils Modulate ILC2 Activities - Elizabeth Jacobsen

Poster 69 - Inhibition of Eosinophil Transendothelial Migration by 5HTP Stimulation of HTR1A and HTR1B in Endothelial Cells - Joan Cook-Mills

Poster 71    PIN1 Regulates IL-5 Induced Eosinophil Polarization and Migration - Zhong-Jian Shen

Poster 73    Adipose Tissue Eosinophils in Cancer-Associated Cachexia - Patrick Lenehan

Poster 75    Pharmacodynamic And Clinical Efficacy Data from Patient Sputum Subgroups in DREAM Treated with Mepolizumab Across A 10-fold Dose Range - Charlene Prazma

Poster 77    Palmitoylation of Galectin-10 in Human Eosinophils - Haibin Wang


Thursday 11 July

07:00 - 08:00 Breakfast with a Mentor Session: How NIH Supports Clinical Trials - Lisa Wheatley, USA

07:00 - 08:00 Breakfast with a Mentor Session: Program Officers, Study Sections, RFA and PAs: Learn the language, protocols and best practices to interact with the NIH - Michael Minnicozzi, USA

Session 3: Eosinophils and Host Defense

08:00 - 08:30 When Eosinophils Meet Viruses - Amali Samarasinghe, USA

08:30 - 09:00 Eosinophils Suppress Th1 Responses and Restrict Bacterially Induced Gastrointestinal Inflammation - Isabelle Arnold, Switzerland

09:00 - 09:30 Eosinophil Phenotypes in Immune Pathways - Elizabeth Jacobsen, USA

Abstract Presentations

09:30 - 09:45 Single Cell RNA Sequencing of Inflammatory Tissue T Cells in Eosinophilic Esophagitis - Ting Wen, USA

09:45 - 10:00 Identification of Eosinophil-Specific Gene-Enhancer Regions - Jennifer Felton, USA


10:00 - 10:30 Morning Break


Session 4: Eosinophils and Nerves

10:30 - 11:00 Maternal Inflammation and Offspring Eosinophils Regulate Airway Nerve Development  - Katie Lebold, USA

11:00 - 11:30 Eosinophils Promote Sensory Nerve Growth in Human Asthma - Matthew Drake, USA

11:30 - 12:00 Eosinophils and Itch - David Jacoby, USA

Abstract Presentations

12:00 - 12:15 Asthma is Associated With Brain Neurodegeneration: A Possible Effect of Eosinophilic Inflammation? - William Busse, USA

12:15 - 12:30 Characterization of a Mouse Model of Heart Disease in Hypereosinophilia - Nives Zimmermann, USA


12:30 - 15:00 Lunch (on your own)


Session 5: Eosinophils and Metabolic Disease

15:00 - 15:30 Extreme IL-33-Dependent Eosinophil Accumulation in Adipose Tissue - Alyssa Hasty, USA

Abstract Presentations

15:30 - 15:45 The Role of Adipose Tissue-Resident Eosinophils in Adipocyte Metabolism and Whole-Body Energy Homeostasis - Elena Anna De Filippis, USA

15:45 - 16:00 Eosinophils in Beige Adipose Tissue Activation - Kate Quinlan, Australia


16:00 - 17:00 Ehrlich Award Winner Lecture - Regulation and Control of Eosinophilia - Marc Rothenberg, USA


17:00 - 19:00 Poster Session 2


Poster 2 - Eosinophils from Normal Donors How Do They Vary? How Do They Define Us? - Caroline Percopo

Poster 4 - Determining the Role of Eotaxin-1 in Eosinophil Development In Order To Promote Heterogeneity via an Ex Vivo Cuture System - Ajinkya Limkar

Poster 6 - Eosinophilia and Hookworm Infection: A Living Drug for Autoimmune Diseases - David Pritchard

Poster 8 - Sustained Long-Term Efficacy and Safety of RPC4046, an Anti-Interleukin-13 Monoclonal Antibody, In Patients with Eosinophilic Esophagitis: Results from the Open-Label Extension of the Heroes Study - Dianne Nguyen

Poster 10 - Markers of Esophageal Epithelial-Mesenchymal Transition (EMT) are Significantly Reduced in Active Eosinophilic Esophagitis Following 16 Weeks of Treatment with RPC4046, an Anti-Interleukin-13 Monoclonal Antibody - Dianne Nguyen

Poster 12 - Differentiation and Activation of Eosinophils in the Human Bone Marrow at Steady State and During Experimental Acute Systemic Inflammation - Marwan Hassani

Poster 14 - Activated Eosinophils Promote an Anti-Tumorigenic Environment in Tumor Models of Colorectal Cancer - Melanie Kienzl

Poster 16 - Vitamin Deficiencies May Vary in Relation to Symptoms and Treatment Approaches for Eosinophilic Esophagitis - Elizabeth Jensen

Poster 18 - Epidermal Expression of Eotaxins-1, 2, and 3 in Bullous Pemphigoid is Comparable to Other Eosinophil Rich Dermatoses: A Retrospective Immunohistochemical Analysis - Kyle Amber

Poster 20 - Detection of Eosinophil Cytolytic Degranulation in Paraffin-Embedded Tissue - Mineyo Fukuchi

Poster 22 - Human Eosinophils Express of Free Fatty Acid Receptor 2 And 3: Possible Implication of These Receptors in Interleukin-4 Production by Short Chain Fatty Acids - Myeong Seong Sim

Poster 24 - Intraesophageal Adminisration of Oxazolon to Skin-Sensitized? Mice Results In Experimental Eosinophilic Esophagitis - Shmuel Avlas

Poster 28 - Regulation of Eosinophil Recruitment in Allergic Airway Inflammation by Tropomyosin Receptor Kinase A - Mythili Dileepan

Poster 30 - Aspergillus Fumigatus-Induced Human Eosinophil Extracellular DNA Traps: Role of IP3K, p38 MAPK and Src Family - Marina Barroso

Poster 32 - Improved Diagnosis of Asthma: Metabolomic Profiling of Urine - Darryl Adamko

Poster 34 - AKST4290, a CCR3 Inhibitor, Is Efficacious In Models of Age-Related Eosinophilic Disorders - Arnaud Teichert

Poster 36 - The TNF Superfamily Member 14 (TNFSF14/Light) Induces Pro-Inflammatory Responses in Fibroblasts in Eosinophilic Esophagitis - Mario Manresa

Poster 38 - Lysophosphatidylserine Induces Eosinophil Extracellular Trap Cell Death - Hye Jeong Kim

Poster 40 - The Thiazolidinediones as Potential Therapeutic Agents for Eosinophilic Esophagitis Pathologic Remodeling: A Preclinical Evaluation - Quan Nhu

Poster 42 - Serum Eotaxin-1/CCL11 Levels Are Elevated in Severe Forms of Systemic Sclerosis - Guillaume Lefèvre

Poster 44 - A Functional Role for Eosinophils in Host Resistance against Mycobacterium Tuberculosis - Katrin Mayer-Barber

Poster 46 - Identification of Reactive Oxygen Species Production Site in Siglec-8 Induced Eosinophil Death - Toshihiro Tomii

Poster 48 - Efficacy and Tolerance of Interferon-Alpha in Hypereosinophilic Syndromes. A Retrospective, Multicenter Study on 29 Patients - Jean Emmanuel Kahn

Poster 50 - Eosinophil Subsets in Pediatric Exacerbation-Prone Asthma - Li Merlin

Poster 52 - Eosinophil Associated Type-2 Gene Expression in Childhood Asthma - Matthew Altman

Poster 54 - Improvement in Quality Of Life (QOL) In Pediatric Patients with Eosinophilc Esophagitis and Food Allergy after Initial Clinic Evaluation - Vibha Szafron

Poster 56 - IL-33 Expression and Potential Activation of Eosinophils Is Associated with ORMDL3 - Elizabeth Mckernan

Poster 58 - Quantifying Mucosal Eosinophilic Inflammation in EOE Using the 1-Hour Esophageal String Test - Milica Grozdanovic

Poster 60 - Elevated Serum Tarc in Patients with Idiopathic Hypereosinophilic Syndrome: A Marker of Lymphocyte- Driven Disease? - Julien Catherine

Poster 62 - IL-13 Treated Esophageal Epithelial Cells Induce Eosinophil Survival and Activation - Julia Dunn

Poster 64 - Effects of Sustained Eosinophil Depletion in Humans - Fei Li Kuang

Poster 66 - Expression and Function of Type 1 and Type 2 Eosinophils - Elizabeth Jacobsen

Poster 68 - Eosinophils Suppress Lung Allograft Rejection - Elizabeth Jacobsen

Poster 70 - Early Life Represents a Vulnerable Time Window for IL-33-Induced Lung Pathology - Hirohito Kita

Poster 72     Multiple Roles of PIN1 in the Regulation of TLR7 Signaling in Eosinophils - Zhong-Jian Shen

Poster 74     Steroid Dose Reducing Effect of Benralizumab, a Monoclonal Antibody to IL-5Ra, In Eosinophilic Granulomatosis with Polyangiitis - Vamsi P. Guntur

Poster 76     Oral Corticosteroid Dose Modulation in Severe Asthma: Impact on Peripheral Blood Eosinophil Count - Charlene Prazma

Poster 78     Eosinophils Dampen Hepatic Ischemia Reperfusion Injury through Interleukine-33 Signaling - Jong-Min Jeong


Friday 12 July

Session 6: Eosinophils in Chronic Inflammatory Disease - Asthma

08:00 - 08:30 ASTHMA - Autoimmune Responses, Eosinophils and Complex Airway Disease - Manali Mukherjee, Canada

08:30 - 09:00 ASTHMA - Anti IL5 Therapies for Severe Asthma: Targeting The Ligand vs The Receptor - Parameswaran Nair, Canada

09:00 - 09:30 LUNG - Targeting Eosinophils in Eosinophil Granulomatosis with Polyangitis - Michael E. Wechsler, USA

Abstract Presentations

09:30 - 09:45 Lung Eosinophils Increase Vagus Nerve Mediated Airway Reflex Bronchoconstriction in Mice - Zhenying Nie, USA

09:45 - 10:00 Idiopathic Eosinophilic Vasculitis, Another Side of Hypereosinophilic Syndrome? A Comprehensive Analysis of 115 Cases in Asthma-Free and ANCA-Negative Patients - Guillaume Lefèvre, France


10:00 - 10:30 Morning Break


Session 7: Eosinophils in Chronic Inflammatory Disease- GI

10:30 - 11:00 ESOPHAGUS - Eosinophilic Esophagitis-like Disease:  Description of a New Disease Entity – Hans-Uwe Simon, Switzerland

11:00 - 11:30 GI OR SUBSETS - Phenotypically Distinct Subsets of Eosinophils Resident in Intestine - Lisa Spencer, USA

11:30 - 12:00 GI - Markers of Chronic Inflammatory Bowel Disease - Marie Carlson, Sweden

12:00 - 12:30 GI and SKIN - A Pathophysiological Potpourri of Conundrums and Challenges in Eosinophil-Related Epithelial Inflammation - Kristin Leiferman, USA

Abstract Presentations

12:30 - 12:45 Functional Role of Kallikrein 5 and Proteinase Activated Receptor (PAR)2 in Eosinophilic Esophagitis - Nurit Azouz, USA

12:45 - 13:00 Efficacy of RPC4046, An Anti-Interleukin-13 Monoclonal Antibody, In Patients with Active Eosinophilic Eosphagitis: Analysis of the Steroid-Refractory Subgroup From the Heroes Study - Dianne Nguyen, USA


13:00 - 15:00 Lunch (on your own)

13:00 - 15:00 CEGIR Lecture Session - "Findings from the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)"

(lunch available for purchase during registration)


Session 8: Eosinophils in Cancer                         

15:00 - 15:30 Activated Eosinophils Exert Distinct Anti-Tumorigenic Activities in Colorectal Cancer - Ariel Munitz, Israel

15:30 - 16:00 Charcot-Leyden Crystals as a Drugable Target in Type 2 Immunity - Bart Lambrecht, United States

Abstract Presentations

16:00 - 16:15 Eosinophils Promote GM-CSF-Dependent Anti-Tumor Immunity Through Activation of Type I T-Cell Responses - Alessandra Gurtner, Switzerland

16:15 - 16:30 Activated Eosinophil Subsets are an Integral Part of the Tumor Microenvironment in Lung Metastasis, Displaying Anti-Tumorigenic Activities - Sharon Grisaru, Israel




Saturday 13 July

Session 9: The Now and Future of Eosinophils as a Drug Target

08:00 - 08:30 “Siglec”ting the Allergic Response for Therapeutic Targeting - Bruce Bochner, USA

08:30 - 09:00 Developing Dexpramipexole for the Treatment of Eosinophilic Disorders - Calman Prussin, USA

09:00 - 09:30 Subtypes of Responders to Treatment in Hypereosinophilic Syndrome - Paneez Khoury, USA

09:30 - 10:00 Eosinophil Depletion in Humans: Is It Safe? - Amy Klion, USA

10:00 - 10:30 EOS, Exacerbations and Adherence…The Good, Bad and Ugly of Severe Asthma - Richard Costello, Ireland

Abstract Presentation

10:30 - 10:45 Alpha IIb Integrin (CD41) on Blood Eosinophils is a Potential Biomarker for Disease Activity in Eosinophilic Esophagitis (EoE) - Mats Johansson, USA


10:45 - 11:15 Morning Break


11:15 - 12:15 Roundtable Discussion 1 - New Emerging or Controversial Topics - Is There More Than One Type of Eosinophil?

12:15 - 13:15  Roundtable Discussion 2 - New Emerging or Controversial Topics - Eosinophils-What are They Good For?

*Schedule Subject to Change

Corporate Advisory Council
Platinum Member

Astra Zeneca

Gold Members

AllakosAmgenGSKSanofi Regeneron

Bronze Members

Areteia TherapeuticsBMSCelldexTakeda